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Your search keyword '"3,4-dihydropyrimidinone"' showing total 2 results
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2 results on '"3,4-dihydropyrimidinone"'

1. Microwave-assisted multicomponent reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their corresponding 2(1H)-thiones using lanthanum oxide as a catalyst under solvent-free conditions

Author

M. Gopalakrishnan, S. Pazhamalai, and A. Kuraitheerthakumaran

Subjects
Chemistry(all), General Chemical Engineering, Biginelli reaction, Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, lcsh:Chemistry, chemistry.chemical_compound, Lanthanum oxide, Irradiation, Solvent-free, 010405 organic chemistry, 3,4-Dihydropyrimidinone, General Chemistry, 0104 chemical sciences, Solvent, lcsh:QD1-999, Thiourea, chemistry, Chemical Engineering(all), Urea, Microwave
Abstract

An efficient synthesis of 3,4-dihydropyrimidinone derivatives using lanthanum oxide as a catalyst, from aldehydes, β-keto ester and urea/thiourea without solvent under the irradiation of microwave is described. Compared with classical Biginelli reaction conditions, this new method has the advantage of excellent yields and shorter reaction times.

Published
2016

2. Ethyl 6-Methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Author

Gustavo Machado das Neves, Itamar Luís Gonçalves, Luciano Porto Kagami, Guilherme Arraché Gonçalves, Gabriel Oliveira de Azambuja, Leonardo Davi, João Pedro Silveira, Vera Lucia Eifler-Lima, and Rômulo Faria Santos Canto

Subjects
chemistry.chemical_classification, 3,4-dihydropyrimidinone, 010405 organic chemistry, Organic Chemistry, Biginelli reaction, Triazole, LaSOM® 293, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, Medicinal chemistry, lcsh:QD146-197, Cycloaddition, 0104 chemical sciences, triazole, chemistry.chemical_compound, chemistry, Yield (chemistry), lcsh:Inorganic chemistry, Urea, Carboxylate, Physical and Theoretical Chemistry, Methylene
Abstract

The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM® 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM® 293 was obtained with a yield of 84%.

Published
2019

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