1. Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association
- Author
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Famke Aeffner, Anil V. Parwani, Andrew H. Beck, Jeroen van der Laak, Emmanuel Agosto-Arroyo, Cleopatra Kozlowski, Jeff Gibbs, Esther Abels, Liron Pantanowitz, Marilyn M. Bui, Venkata N. P. Vemuri, and Mark D. Zarella
- Subjects
0301 basic medicine ,media_common.quotation_subject ,Best practice ,Review ,Field (computer science) ,Pathology and Forensic Medicine ,Terminology ,Workflow ,artificial intelligence ,computational pathology ,convolutional neural networks ,digital pathology ,deep learning ,image analysis ,machine learning ,03 medical and health sciences ,0302 clinical medicine ,White paper ,Predictive Value of Tests ,Datorseende och robotik (autonoma system) ,Terminology as Topic ,Image Interpretation, Computer-Assisted ,Pathology ,Humans ,Quality (business) ,Diagnosis, Computer-Assisted ,Policy Making ,Computer Security ,Computer Vision and Robotics (Autonomous Systems) ,media_common ,Perspective (graphical) ,Digital pathology ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Benchmarking ,030104 developmental biology ,030220 oncology & carcinogenesis ,Engineering ethics ,Psychology - Abstract
In this white paper, experts from the Digital Pathology Association (DPA) define terminology and concepts in the emerging field of computational pathology, with a focus on its application to histology images analyzed together with their associated patient data to extract information. This review offers a historical perspective and describes the potential clinical benefits from research and applications in this field, as well as significant obstacles to adoption. Best practices for implementing computational pathology workflows are presented. These include infrastructure considerations, acquisition of training data, quality assessments, as well as regulatory, ethical, and cyber‐security concerns. Recommendations are provided for regulators, vendors, and computational pathology practitioners in order to facilitate progress in the field. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
- Published
- 2019