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5 results on '"Shah, Amar"'

1. CT on the Diamond Princess: What Might This Tell Us About Sensitivity for COVID-19?

Author

Isikbay, Masis, Hope, Michael D., Raptis, Constantine A., Shah, Amar, Bierhals, Andrew J., Bhalla, Sanjeev, Hammer, Mark M., Kligerman, Seth J., Jeudy, Jean, Filev, Peter D., Henry, Travis S., Inui, Shohei, Fujikawa, Akira, Jitsu, Motoyuki, Kunishima, Naoaki, Watanabe, Sadahiro, Suzuki, Yuhi, Umeda, Satoshi, and Uwabe, Yasuhide

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), engineering, Medicine, Diamond, Radiology, Nuclear Medicine and imaging, Sensitivity (control systems), engineering.material, business, Letter to the Editor, Virology
Published
2021

2. Additional file 1 of Is a differentiated care model needed for patients with TB? A cohort analysis of risk factors contributing to unfavourable outcomes among TB patients in two states in South India

Author

Washington, Reynold, Potty, Rajaram Subramanian, A. Rajesham, T. Seenappa, Singarajipura, Anil, Swamickan, Reuben, Shah, Amar, K. H. Prakash, Kar, Arin, Karthikeyan Kumaraswamy, B. S. Prarthana, Maryala, Bala Krishna, J. Sushma, Dasari, Ramesh, Bharath Shetty, Panibatla, Vikas, H. L. Mohan, and Becker, Marissa

Abstract

Additional file 1. Tool for risk and needs assessment (RANA).

Published
2020
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3. Additional file 2 of Is a differentiated care model needed for patients with TB? A cohort analysis of risk factors contributing to unfavourable outcomes among TB patients in two states in South India

Author

Washington, Reynold, Potty, Rajaram Subramanian, A. Rajesham, T. Seenappa, Singarajipura, Anil, Swamickan, Reuben, Shah, Amar, K. H. Prakash, Kar, Arin, Karthikeyan Kumaraswamy, B. S. Prarthana, Maryala, Bala Krishna, J. Sushma, Dasari, Ramesh, Bharath Shetty, Panibatla, Vikas, H. L. Mohan, and Becker, Marissa

Subjects
ComputerSystemsOrganization_MISCELLANEOUS, Data_FILES
Abstract

Additional file 2. Prevention Care and Support Card (PCS).

Published
2020
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4. Obituary

Author

Shah, Amar

Subjects
Pediatrics, Perinatology and Child Health, Surgery, Obituary
Published
2020

5. Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men

Author

Narayanaswamy, Shakunthala, Prague, Julia K., Jayasena, Channa N., Papadopoulou, Deborah A., Mizamtsidi, Maria, Shah, Amar J., Bassett, Paul, Comninos, Alexander N., Abbara, Ali, Bloom, Stephen R., Veldhuis, Johannes D., Dhillo, Waljit S., and Medical Research Council (MRC)

Subjects
Adult, Male, Kisspeptins, Neurotransmitter Agents, Neurokinin B, Narcotic Antagonists, 1103 Clinical Sciences, Original Articles, Middle Aged, Naltrexone, Endocrinology & Metabolism, Gene Expression Regulation, 1114 Paediatrics And Reproductive Medicine, Humans, Drug Therapy, Combination, Single-Blind Method, Prospective Studies, Gonadotropins, hormones, hormone substitutes, and hormone antagonists
Abstract

Context: A subpopulation of hypothalamic neurons colocalize three neuropeptides, namely kisspeptin, neurokinin B (NKB), and dynorphin, collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis); kisspeptin stimulates, NKB modulates, and dynorphin (an opioid) inhibits. Objective: To investigate the KNDy hypothesis in humans, we assessed for the first time the effects of the coadministration of kisspeptin-54, NKB, and an opioid receptor antagonist, naltrexone, on LH pulsatility (surrogate marker for GnRH pulsatility) and gonadotropin release. Design, Setting, and Participants: This was an ethically approved prospective, single-blinded, placebo-controlled study. Healthy male volunteers (n = 5/group) attended our research facility for eight study visits. Intervention and Main Outcome Measure: After 1 hour of baseline blood sampling, participants received a different intervention at each visit: oral 50 mg naltrexone, 8-hour iv infusions of vehicle, 2.56 nmol/kg · h NKB, 0.1 nmol/kg · h kissspeptin-54 (KP) alone and in combination. Frequent blood sampling to measure plasma gonadotropins and sex steroids was conducted and LH pulsatility was determined using blinded deconvolution analysis. Results: All kisspeptin and naltrexone containing groups potently increased LH and LH pulsatility (P < .001 vs vehicle). NKB alone did not affect gonadotropins. NKB+KP had significantly lower increases in gonadotropins compared with kisspeptin alone (P < .01). Naltrexone+KP was the only group to significantly increase LH pulse amplitude (P < .001 vs vehicle). Conclusions: Our results suggest significant interactions between the KNDy neuropeptides on LH pulsatility and gonadotropin release in humans. This has important implications for improving our understanding of GnRH pulse generation in humans., Co-administration of kisspeptin-54, NKB and an opioid antagonist naltrexone result in significant interactions to modulate LH pulsatility and gonadotrophin release in humans.

Published
2016

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