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Introduction The transition from medical student to surgical resident is not a simple one. The aim of this study was to report the experience of a university hospital in the organization of the induction course for future surgical residents and the contribution of a video support in the learning of the suture. Material and method We were able to study two consecutive years of students (October 2020 and 2021). Concerning the practical and technical workshops (learning suture) we carried out a comparative study between two groups of students. A group that had video support for learning suture (video group) and a group without video (control group). The evaluation of the suture was performed in a blinded manner by two supervising surgeons. The other practical workshop was drain fixation; the students did not have a video for this workshop. A comparative study was also performed for the drain fixation workshop between the two groups (video group and control group). A program of theoretical courses was also set up. This program is established according to the different future functions of the residents by integrating medico-legal notions and teamwork. Satisfaction questionnaires were given to the students and the answers were given two months after taking up their duties in the hospital (6 questions with Likert scale and 4 free questions). Results The cohort consisted of 58 students (29 each in 2020 and 29 in 2021). Comparative analyses of the evaluation of the suture workshops showed better performance in the video group compared with the group without video. The comparison of these two groups did not show significant differences in the drain fixation workshop. The theoretical teaching was broken down according to the students' future tasks and each speaker was a specialist in his or her field of expertise. The results of the questionnaires showed a desire on the part of the students to increase the time spent on practical workshops and theoretical forensic teaching. Conclusion We were able to show through these two years of a program that we were able to offer a surgical resident preparation course. In addition, we have highlighted the contribution of a video support in the learning curve of the suture.

International audience; Resistance of acute myeloid leukemia (AML) to therapeutic agents is frequent. Consequently, the mechanisms leading tothis resistance must be understood and addressed. In this paper, we demonstrate that inhibition of deubiquitinylaseUSP7 significantly reduces cell proliferation in vitro and in vivo, blocks DNA replication progression and increases celldeath in AML. Transcriptomic dataset analyses reveal that a USP7 gene signature is highly enriched in cells from AMLpatients at relapse, as well as in residual blasts from patient-derived xenograft (PDX) models treated with clinically relevantdoses of cytarabine, which indicates a relationship between USP7 expression and resistance to therapy. Accordingly, singlecellanalysis of AML patient samples at relapse versus at diagnosis showed that a gene signature of the pre-existingsubpopulation responsible for relapse is enriched in transcriptomes of patients with a high USP7 level. Furthermore, wefound that USP7 interacts and modulates CHK1 protein levels and functions in AML. Finally, we demonstrated that USP7inhibition acts in synergy with cytarabine to kill AML cell lines and primary cells of patients with high USP7 levels.Altogether, these data demonstrate that USP7 is both a marker of resistance to chemotherapy and a potential therapeutictarget in overcoming resistance to treatment.