1. Study of expression and functional activity of P-GP membrane glycoprotein in children with acute leukemia
- Author
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O. V. Aleinikova, M. P. Potapnev, V. P. Savitskii, and T. V. Shman
- Subjects
Adolescent ,Lymphoblastic Leukemia ,Gene Expression ,Primary disease ,Statistics, Nonparametric ,General Biochemistry, Genetics and Molecular Biology ,hemic and lymphatic diseases ,medicine ,Humans ,CD135 ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Child ,Acute leukemia ,biology ,business.industry ,Antibodies, Monoclonal ,Infant ,Myeloid leukemia ,hemic and immune systems ,General Medicine ,Carbocyanines ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Flow Cytometry ,Prognosis ,medicine.disease ,Survival Analysis ,Leukemia, Myeloid, Acute ,Leukemia ,Membrane glycoproteins ,Child, Preschool ,Cancer research ,biology.protein ,Functional activity ,Benzimidazoles ,business - Abstract
We studied expression and functional activity of tumor cell P-gp in children with various leukemia variants and analyzed its prognostic role in acute lymphoblastic leukemia. Functional activity of P-gp increased in acute myeloid leukemia, relapses of acute lymphoblastic leukemia (in comparison with primary disease), and in a group of patients in whom no remission was attained. The survival of patients with acute lymphoblastic leukemia was lower in cases with increased expression and function of P-gp.
- Published
- 2006
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