151. Paper-based microfluidics for rapid diagnostics and drug delivery
- Author
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Zhugen Yang, Kang Mao, Xiaocui Min, Hua Zhang, Kuankuan Zhang, Haorui Cao, and Yongkun Guo
- Subjects
0303 health sciences ,Medical diagnostic ,Foodborne pathogen ,Computer science ,Microfluidics ,Loop-mediated isothermal amplification ,diagnostic ,Pharmaceutical Science ,02 engineering and technology ,Paper based ,021001 nanoscience & nanotechnology ,03 medical and health sciences ,Paper-based microfluidics ,Molecular Diagnostic Techniques ,Pharmaceutical Preparations ,Infectious disease diagnosis ,LAMP ,Lab-On-A-Chip Devices ,drug delivery ,Drug delivery ,Systems engineering ,0210 nano-technology ,Nucleic Acid Amplification Techniques ,030304 developmental biology - Abstract
Paper is a common material that is promising for constructing microfluidic chips (lab-on-a-paper) for diagnostics and drug delivery for biomedical applications. In the past decade, extensive research on paper-based microfluidics has accumulated a large number of scientific publications in the fields of biomedical diagnosis, food safety, environmental health, drug screening and delivery. This review focuses on the recent progress on paper-based microfluidic technology with an emphasis on the design, optimization and application of the technology platform, in particular for medical diagnostics and drug delivery. Novel advances have concentrated on engineering paper devices for point-of-care (POC) diagnostics, which could be integrated with nucleic acid-based tests and isothermal amplification experiments, enabling rapid sample-to-answer assays for field testing. Among the isothermal amplification experiments, loop-mediated isothermal amplification (LAMP), an extremely sensitive nucleic acid test, specifically identifies ultralow concentrations of DNA/RNA from practical samples for diagnosing diseases. We thus mainly focus on the paper device-based LAMP assay for the rapid infectious disease diagnosis, foodborne pathogen analysis, veterinary diagnosis, plant diagnosis, and environmental public health evaluation. We also outlined progress on paper microfluidic devices for drug delivery. The paper concludes with a discussion on the challenges of this technology and our insights into how to advance science and technology towards the development of fully functional paper devices in diagnostics and drug delivery.
- Published
- 2020