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The integrated shear 3-point correlation function $\zeta_{\pm}$ measures the correlation between the local shear 2-point function $\xi_{\pm}$ and the 1-point shear aperture mass in patches of the sky. Unlike other higher-order statistics, $\zeta_{\pm}$ can be efficiently measured from cosmic shear data, and it admits accurate theory predictions on a wide range of scales as a function of cosmological and baryonic feedback parameters. Here, we develop and test a likelihood analysis pipeline for cosmological constraints using $\zeta_{\pm}$. We incorporate treatment of systematic effects from photometric redshift uncertainties, shear calibration bias and galaxy intrinsic alignments. We also develop an accurate neural-network emulator for fast theory predictions in MCMC parameter inference analyses. We test our pipeline using realistic cosmic shear maps based on $N$-body simulations with a DES Y3-like footprint, mask and source tomographic bins, finding unbiased parameter constraints. Relative to $\xi_{\pm}$-only, adding $\zeta_{\pm}$ can lead to $\approx 10-25\%$ improvements on the constraints of parameters like $A_s$ (or $\sigma_8$) and $w_0$. We find no evidence in $\xi_{\pm} + \zeta_{\pm}$ constraints of a significant mitigation of the impact of systematics. We also investigate the impact of the size of the apertures where $\zeta_{\pm}$ is measured, and of the strategy to estimate the covariance matrix ($N$-body vs. lognormal). Our analysis solidifies the strong potential of the $\zeta_{\pm}$ statistic and puts forward a pipeline that can be readily used to improve cosmological constraints using real cosmic shear data., Comment: 21 pages, 11 figures, 3 tables. Comments welcome