101 results on '"Zhongjian Xie"'
Search Results
2. Sugarcane Node Detection Method Based on Photoelectric Sensor Vertical Projection Signal Processing
- Author
-
Chunming Wen, Zhanpeng Xiao, Yunzhi Yan, Youzong Huang, Zhongjian Xie, Hongliang Nong, Zimian Lan, Yuchun Lu, and Qiaohui Wu
- Subjects
Biomedical Engineering ,Soil Science ,Forestry ,Agronomy and Crop Science ,Food Science - Abstract
Highlights A linear array CCD sensor is utilized to obtain the contour signal of the vertical projection of the sugarcane. A method is provided for continuously identifying and locating sugarcane nodes. Examines the impact of scan speed and illumination on the accuracy of identification. The method performs well regarding identification rate, precision, and efficiency. Abstract. In order to achieve continuous and dynamic detection of sugarcane nodes, improve the automatic production efficiency of pre-cut sugarcane seed, and lower the cost of mechanized sugarcane production, a detection method based on linear array charge-coupled device (CCD) photoelectric sensor signal processing was developed. Firstly, the mechanical drive unit was controlled to drive the photoelectric detection system to acquire the signal of the vertical projection of the sugarcane profile. The projection information was then binarized into profile information using the Otsu algorithm. The profile signal was then decomposed using a variable mode decomposition algorithm optimized based on the sparrow search algorithm, and the component reflecting the node content was regarded as the feature signal. Finally, the position of the wave peaks above the judgment threshold in the normalized feature signal was considered the position of the sugarcane nodes. One-way and two-way experiments were conducted to investigate the effects of scan speed and illuminance on identification precision. The results showed that the identification rate, average response time, and average error values were 98.40%, 0.13 s, and 1.36 mm at a scan speed of 75 mm/s and an illuminance of 91.91 lx. Compared to other node identification methods discussed in this article, the proposed method has a high identification rate and accuracy with a high response speed, which can improve the automation efficiency of sugarcane seed production. Keywords: Identification accuracy, Non-contact detection, Photoelectric sensor, Precision agriculture, Seed production, Signal processing, Sugarcane node, Variational mode decomposition.
- Published
- 2023
3. Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment
- Author
-
Chaozhou Li, Hui Tan, Ruitao Lu, Sainan Qin, Xiangying Meng, Han Zhang, and Zhongjian Xie
- Subjects
Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Biotechnology - Abstract
Photodynamic therapy (PDT) has lately been identified as a promising anticancer method and gained tremendous interest due to its controllability, non-invasive nature, and negligible side effects. Nevertheless, the development of PDT is hampered by two factors. One is the insufficient tissue penetration of phototherapy laser, resulting in restricted treatment sites. Another one is the substantial dependence of reactive oxygen species (ROS) formation on oxygen concentration. Therefore, a strategy to promote ROS generation by overcoming the hypoxia microenvironment is critical to cancer therapy. Electrolysis of water is known to be a rapid and relatively secure method for producing oxygen. Thus, in this study, electrotherapy was introduced to alleviate the tumor hypoxia by producing oxygen in situ, hence boosting the PDT efficacy, namely E-PDT. Black phosphorus (BP) based nanomaterials were selected as clearable photosensitizers with outstanding PDT performance. Experiments conducted both in vitro and in vivo indicated that E-PDT performed superior therapeutic effects with the in situ generation of oxygen by electrotherapy compared with other groups. This work suggests a promising strategy for phototherapeutic anticancer efficiency enhancement.
- Published
- 2022
4. Three birds with one stone: oxygen self-supply engineering palladium nanocluster/titanium carbide hybrid for single-NIR laser-triggered synergistic photodynamic-photothermal therapy
- Author
-
Shanshan Dang, Yanmei Mo, Junqing Zeng, Yunjie Xu, Zhongjian Xie, Han Zhang, Bin Zhang, and Guohui Nie
- Subjects
Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Biotechnology - Abstract
As a key branch of the cross-discipline biophotonics, phototherapy, including photodynamic therapy (PDT), and photothermal therapy (PTT), is promising in biomedicine and visible light-driving PDT has been applied to clinical treatment. However, extensive applications of phototherapy are limited by the hypoxic microenvironment, laser penetration depth, and potential complexity for combined PDT/PTT. Thus, NIR-responsive oxygen self-supply nanocomposites functionalized with photosensitizers for achieving simultaneous in-depth PDT/PTT are urgently required. Herein, a multifunctional platform has been fabricated by co-immobilizing monodispersed ultrasmall Pd nanoclusters and a photosensitizer 5,10,15,20-Tetrakis (4-Aminophenyl)-21H,23H Porphyrin (Thp) on the surface of Ti3C2T x MXene nanosheets, generating the Pd-Thp-Ti3C2T x nanocomposite. Material characterization demonstrated that Pd nanoclusters and Thp were well-distributed on the MXene surface while MXene maintained its photothermal conversion efficiency and broad absorption. In this nanoplatform, irradiated by the single 808 nm laser, Pd selectively catalyzed the decomposition of H2O2 to O2, and O2 was continuously supplied to Thp for enhanced NIR-driving PDT. The in vivo fluorescence and photothermal imaging demonstrated the pronounced accumulation of nanocomposites in the tumor site. Both in vitro and in vivo results clearly demonstrated the nanocomposite had good biocompatibility, and that the synergistic PTT and enhanced PDT made apoptosis of the tumor cell achievable. This work not only proves this Pd-Thp-Ti3C2T x nanocomposite serves a promising solution for tumor hypoxia by inducing apoptosis of tumor cells with synergistic PTT and PDT, but also broadens the application of promising optical materials in biomedical field.
- Published
- 2022
5. CRISPR-Cas13a-powered electrochemical biosensor for the detection of the L452R mutation in clinical samples of SARS-CoV-2 variants
- Author
-
Zhi Chen, Chenshuo Wu, Yuxuan Yuan, Zhongjian Xie, Tianzhong Li, Hao Huang, Shuang Li, Jiefeng Deng, Huiling Lin, Zhe Shi, Chaozhou Li, Yabin Hao, Yuxuan Tang, Yuehua You, Omar A. Al-Hartomy, Swelm Wageh, Abdullah G. Al-Sehemi, Ruitao Lu, Ling Zhang, Xuechun Lin, Yaqing He, Guojun Zhao, Defa Li, and Han Zhang
- Subjects
Biomedical Engineering ,Pharmaceutical Science ,Molecular Medicine ,Medicine (miscellaneous) ,Bioengineering ,Applied Microbiology and Biotechnology - Abstract
Since the end of 2019, a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has deprived numerous lives worldwide, called COVID-19. Up to date, omicron is the latest variant of concern, and BA.5 is replacing the BA.2 variant to become the main subtype rampaging worldwide. These subtypes harbor an L452R mutation, which increases their transmissibility among vaccinated people. Current methods for identifying SARS-CoV-2 variants are mainly based on polymerase chain reaction (PCR) followed by gene sequencing, making time-consuming processes and expensive instrumentation indispensable. In this study, we developed a rapid and ultrasensitive electrochemical biosensor to achieve the goals of high sensitivity, the ability of distinguishing the variants, and the direct detection of RNAs from viruses simultaneously. We used electrodes made of MXene-AuNP (gold nanoparticle) composites for improved sensitivity and the CRISPR/Cas13a system for high specificity in detecting the single-base L452R mutation in RNAs and clinical samples. Our biosensor will be an excellent supplement to the RT-qPCR method enabling the early diagnosis and quick distinguishment of SARS-CoV-2 Omicron BA.5 and BA.2 variants and more potential variants that might arise in the future.
- Published
- 2023
6. Association of early-life famine exposure with low bone mass in adulthood
- Author
-
Wenting Qi, Lijia Cui, Xiangjun Yin, Wei Yu, Nan Zhao, Lin Chen, Shunyu Tang, Hua Lin, Lu Cui, Xiaolan Jin, Zhongjian Xie, Ning Jiang, Steven R. Cummings, Zhixin Li, Linhong Wang, and Weibo Xia
- Subjects
Orthopedics and Sports Medicine - Published
- 2023
7. Recent Progress in Emerging Novel MXenes Based Materials and their Fascinating Sensing Applications
- Author
-
Karim Khan, Ayesha Khan Tareen, Muhammad Iqbal, Zhang Ye, Zhongjian Xie, Asif Mahmood, Nasir Mahmood, and Han Zhang
- Subjects
Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Published
- 2023
8. Characteristics, properties, synthesis and advanced applications of 2D graphdiyne versus graphene
- Author
-
Ying Zhao, Luxiao Chai, Xiaobing Yan, Weichun Huang, Taojian Fan, Omar A. Al-Hartomy, Ahmed Al-Ghamdi, Swelm Wageh, Abdullah G. Al-Sehemi, Zhongjian Xie, and Han Zhang
- Subjects
Materials Chemistry ,General Materials Science - Abstract
Graphdiyne is a newly discovered two-dimensional planar carbon allotrope with highly π-conjugated interactions. This review aims to introduce graphdiyne and describe its similarities and differences with graphene to better understand the graphdiyne.
- Published
- 2022
9. Effective Protection Against Infectious Viruses by Janus Facemasks
- Author
-
Mengke Wang, Yi Hu, Yingzi Hu, Jun Zhu, Junmei Pu, Songrui Wei, Zhongjian Xie, You Zi, Zhi Chen, Weichun Huang, and Han Zhang
- Published
- 2023
10. Highly Efficient, Remarkable Oxygen Reduction Reaction (Orr) Activity of Vanadium Doped Mayenite Electride Nanocomposite
- Author
-
Karim Khan, Ayesha Khan Tareen, Muhammad Iqbal, Waqas Ahmad, Asif Mahmood, Nasir mahmood, Zhang Ye, Zhongjian Xie, Jinde Yin, Muhammad Farooq Khan, and Han Zhang
- Published
- 2023
11. Light-induced tumor theranostics based on chemical-exfoliated borophene
- Author
-
Zhongjian Xie, Yanhong Duo, Taojian Fan, Yao Zhu, Shuai Feng, Chuanbo Li, Honglian Guo, Yanqi Ge, Shakeel Ahmed, Weichun Huang, Huiling Liu, Ling Qi, Rui Guo, Defa Li, Paras N. Prasad, and Han Zhang
- Subjects
Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Abstract
Among 2D materials (Xenes) which are at the forefront of research activities, borophene, is an exciting new entry due to its uniquely varied optical, electronic, and chemical properties in many polymorphic forms with widely varying band gaps including the lightest 2D metallic phase. In this paper, we used a simple selective chemical etching to prepare borophene with a strong near IR light-induced photothermal effect. The photothermal efficiency is similar to plasmonic Au nanoparticles, with the added benefit of borophene being degradable due to electron deficiency of boron. We introduce this selective chemical etching process to obtain ultrathin and large borophene nanosheets (thickness of ~4 nm and lateral size up to ~600 nm) from the precursor of AlB2. We also report first-time observation of a selective Acid etching behavior showing HCl etching of Al to form a residual B lattice, while HF selectively etches B to yield an Al lattice. We demonstrate that through surface modification with polydopamine (PDA), a biocompatible smart delivery nanoplatform of B@PDA can respond to a tumor environment, exhibiting an enhanced cellular uptake efficiency. We demonstrate that borophene can be more suitable for safe photothermal theranostic of thick tumor using deep penetrating near IR light compared to gold nanoparticles which are not degradable, thus posing long-term toxicity concerns. With about 40 kinds of borides, we hope that our work will open door to more discoveries of this top-down selective etching approach for generating borophene structures with rich unexplored thermal, electronic, and optical properties for many other technological applications.
- Published
- 2022
12. Nanomaterials for neurodegenerative diseases: Molecular mechanisms guided design and applications
- Author
-
Pengcheng Yan, Han Zhang, Zhongjian Xie, Xueyan Hou, Xiaohan Duan, Yu Qi, Tianzhong Li, and Haoru Zhu
- Subjects
Clinical trial ,medicine.medical_specialty ,Drug development ,business.industry ,Medicine ,General Materials Science ,Disease ,Electrical and Electronic Engineering ,Disease pathogenesis ,Condensed Matter Physics ,business ,Intensive care medicine ,Atomic and Molecular Physics, and Optics - Abstract
Successful treatment of neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), remains a significant challenge for neurologists due to the undesirable curative outcomes. Apart from surgeries, most drugs are only used to relieve the patients’ symptoms without a permanent cure of the disease. The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms. Considering the difficulties in NDD drug development and clinical trials, a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed. In the current article, the basic concepts and pathogenic characteristics of NDDs are firstly illustrated. Following the detailed description of molecular mechanisms underlying three common NDDs, recent advances of drug development based on targeting different pathogenic mechanisms are clarified. Hopefully, this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine.
- Published
- 2021
13. Recent advances in the development of nanomedicines for the treatment of ischemic stroke
- Author
-
Bing Wang, Ke Zhang, Taojian Fan, Wen Chen, Weiyuan Liang, Bo Han, Nan Li, Ghulam Abbas, Hao Huang, Zhongjian Xie, Ning Liu, Wentian Zhao, and Tian Xing
- Subjects
medicine.medical_specialty ,QH301-705.5 ,Human life ,0206 medical engineering ,Biomedical Engineering ,02 engineering and technology ,Article ,Biomaterials ,medicine ,Biology (General) ,Intensive care medicine ,Metal nanoparticles ,Materials of engineering and construction. Mechanics of materials ,Stroke ,Nanomaterials ,Blood-brain barrier ,business.industry ,021001 nanoscience & nanotechnology ,medicine.disease ,020601 biomedical engineering ,Stroke treatment ,Applications of nanotechnology ,Drug development ,Ischemic stroke ,TA401-492 ,Nanomedicine ,0210 nano-technology ,business ,Biotechnology - Abstract
Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic options available to treat stroke because of limited blood-brain penetration. The development of nanotechnology may overcome some of the problems related to traditional drug development. In this review, we focus on the potential applications of nanotechnology in stroke. First, we will discuss the main molecular pathological mechanisms of ischemic stroke to develop a targeted strategy. Second, considering the important role of the blood-brain barrier in stroke treatment, we also delve mechanisms by which the blood-brain barrier protects the brain, and the reasons why the therapeutics must pass through the blood-brain barrier to achieve efficacy. Lastly, we provide a comprehensive review related to the application of nanomaterials to treat stroke, including liposomes, polymers, metal nanoparticles, carbon nanotubes, graphene, black phosphorus, hydrogels and dendrimers. To conclude, we will summarize the challenges and future prospects of nanomedicine-based stroke treatments., Graphical abstract Image 1, Highlights • Discussed the main molecular pathological mechanisms of ischemic stroke. • Reviewed several treatments for stroke. • Discussed the blood-brain barrier in detail.Summarized the applications of various nanomaterials in stroke. • Summarized the challenges and future prospects of nanomedicine-based stroke treatment.
- Published
- 2021
14. Glioma diagnosis and therapy: Current challenges and nanomaterial-based solutions
- Author
-
Tianzhong Li, Jingfeng Li, Zhi Chen, Shaohui Zhang, Shunling Li, S. Wageh, Omar A. Al-Hartomy, Abdullah G. Al-Sehemi, Zhongjian Xie, Ranjith Kumar Kankala, and Han Zhang
- Subjects
Nanomedicine ,Brain Neoplasms ,Blood-Brain Barrier ,Tumor Microenvironment ,Pharmaceutical Science ,Humans ,Glioma ,Nanostructures - Abstract
Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain tumors at an annual incidence rate of 30-80 per a million population. Although glioma treatment remains a significant challenge for researchers and clinicians, the rapid development of nanomedicine provides tremendous opportunities for long-term glioma therapy. However, several obstacles impede the development of novel therapeutics, such as the very tight blood-brain barrier (BBB), undesirable hypoxia, and complex tumor microenvironment (TME). Several efforts have been dedicated to exploring various nanoformulations for improving BBB permeation and precise tumor ablation to address these challenges. Initially, this article briefly introduces glioma classification and various pathogenic factors. Further, currently available therapeutic approaches are illustrated in detail, including traditional chemotherapy, radiotherapy, and surgical practices. Then, different innovative treatment strategies, such as tumor-treating fields, gene therapy, immunotherapy, and phototherapy, are emphasized. In conclusion, we summarize the article with interesting perspectives, providing suggestions for future glioma diagnosis and therapy improvement.
- Published
- 2022
15. CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant
- Author
-
Chenshuo Wu, Zhi Chen, Chaozhou Li, Yabin Hao, Yuxuan Tang, Yuxuan Yuan, Luxiao Chai, Taojian Fan, Jiangtian Yu, Xiaopeng Ma, Omar A. Al-Hartomy, S. Wageh, Abdullah G. Al-Sehemi, Zhiguang Luo, Yaqing He, Jingfeng Li, Zhongjian Xie, and Han Zhang
- Subjects
Electrical and Electronic Engineering ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now, which is time-consuming and requires expensive instrumentation, and the confirmation of variants relies on further sequencing techniques. Herein, we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid, highly sensitivity and specificity for the detection of SARS-CoV-2 variant. To enhance the sensing capability, gold electrodes are uniformly decorated with electro-deposited gold nanoparticles. Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model, our biosensor exhibits excellent analytical detection limit (50 fM) and high linearity (R2 = 0.987) over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays. The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system. Furthermore, based on the wireless micro-electrochemical platform, the proposed biosensor reveals promising application ability in point-of-care testing.
- Published
- 2022
16. Phase Inversion-Based foam hydrogels for highly efficient Solar-Powered interfacial desalination
- Author
-
Chenyang Xing, Zihao Li, Shaohui Zhang, Jian Bang, Zhongjian Xie, Han Zhang, and Zhengchun Peng
- Subjects
General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
17. Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 axis
- Author
-
Jia Zhang, Pengdong Li, Guifang Zhao, Siqi He, Di Xu, Weijie Jiang, Qian Peng, Zhaohui Li, Zhongjian Xie, Han Zhang, Ying Xu, and Ling Qi
- Subjects
Lipopolysaccharides ,Receptors, Steroid ,Receptors, Thyroid Hormone ,Anti-Inflammatory Agents ,Medicine (miscellaneous) ,Mesenchymal Stem Cells ,Nerve Tissue Proteins ,Cell Biology ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Retina ,DNA-Binding Proteins ,Disease Models, Animal ,Extracellular Vesicles ,Mice ,MicroRNAs ,Molecular Medicine ,Animals ,Cytokines ,Retinitis Pigmentosa - Abstract
Background Retinitis pigmentosa is a rod-cone degenerative disease that induces irreversible vision loss. This study probed the protective capacity of mesenchymal stem cell-derived small EVs (MSC-EVs) on the retinas of rd10 mice and the underlying mechanism. Methods MSC-EVs were injected into the vitreous of rd10 mice at postnatal day 14 and P21; morphology and function were examined at P28. The mechanism of action was explored by using co-culture of photoreceptor cell line 661 W and microglia cell line BV2. Results Treatment with MSC-EVs increased the survival of photoreceptors and preserved their structure. Visual function, as reflected by optomotor and electroretinogram responses, was significantly enhanced in MSC-EVs-treated rd10 mice. Mechanistically, staining for Iba1, GFAP, F4/80, CD68 and CD206 showed that MSC-EVs suppressed the activation of microglial, Müller glial and macrophages. Furthermore, western blotting showed that the treatment inhibited the NF-κB pathway. RNA-seq and qPCR showed that MSC-EVs upregulated anti-inflammatory cytokines while downregulating pro-inflammatory cytokines. MSC-EVs application in vitro decreased the number of TUNEL-positive 661 W cells co-cultured with LPS-stimulated BV2, with similar impact on the cytokine expression as in vivo study. Genetic screening predicted miR-146a to be the downstream target of MSC-EVs, which was detected in MSC-EVs and upregulated in co-cultured 661 W cells and BV2 cells after MSC-EVs treatment. Upregulation of miR-146a by using its mimic decreased the expression of the transcription factor Nr4a3, and its downregulation inhibition promoted Nr4a3 expression in both 661 W and BV2 cells. Nr4a3 was further identified as the target gene of miR-146a by dual-luciferase assay. Furthermore, overexpressing miR-146a significantly decreased the expression of LPS-induced pro-inflammatory cytokines in BV2 cells. Conclusions MSC-EVs delays retinal degeneration in rd10 mice mainly by its anti-inflammatory effect via the miR-146a-Nr4a3axis. Hence, MSC-EVs may be used in the treatment of neurodegenerative diseases.
- Published
- 2022
18. A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2
- Author
-
Zhi Chen, Jingfeng Li, Tianzhong Li, Taojian Fan, Changle Meng, Chaozhou Li, Jianlong Kang, Luxiao Chai, Yabin Hao, Yuxuan Tang, Omar A Al-Hartomy, Swelm Wageh, Abdullah G Al-Sehemi, Zhiguang Luo, Jiangtian Yu, Yonghong Shao, Defa Li, Shuai Feng, William J Liu, Yaqing He, Xiaopeng Ma, Zhongjian Xie, and Han Zhang
- Subjects
Multidisciplinary - Abstract
The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-CoV-2 variants, including Omicron, are required to be identified as soon as the samples are identified as ‘positive’. Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time, we have developed MOPCS (Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance (SPR) with the ‘gene scissors’ clustered regularly interspaced short palindromic repeat (CRISPR) technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants. MOPCS is a low-cost, CRISPR/Cas12a-system-empowered SPR gene-detecting platform that can analyze viral RNA, without the need for amplification, within 38 min from sample input to results output, and achieve a limit of detection of 15 fM. MOPCS achieves a highly sensitive analysis of SARS-CoV-2, and mutations appear in variants B.1.617.2 (Delta), B.1.1.529 (Omicron) and BA.1 (a subtype of Omicron). This platform was also used to analyze some recently collected patient samples from a local outbreak in China, identified by the Centers for Disease Control and Prevention. This innovative CRISPR-empowered SPR platform will further contribute to the fast, sensitive and accurate detection of target nucleic acid sequences with single-base mutations.
- Published
- 2022
19. Ultrasound combined with nanomaterials for cancer therapy
- Author
-
Yao Zhu, Yingying Liu, Karim Khan, Gulzira Arkin, Ayesha Khan Tareen, Zhongjian Xie, Tianzhen He, Lili Su, Fengjuan Guo, XiaoShu Lai, Jinfeng Xu, and Jianglin Zhang
- Subjects
Mechanical Engineering ,General Materials Science - Published
- 2023
20. Highly efficient, remarkable sensor activity and energy storage properties of MXenes and borophene nanomaterials
- Author
-
Chuan Li, Ayesha Khan Tareen, Karim Khan, JianYu Long, Iftikhar Hussain, Muhammad Farooq Khan, Muhammad Iqbal, Zhongjian Xie, Ye Zhang, Asif Mahmood, Nasir Mahmood, Waqas Ahmad, and Han Zhang
- Subjects
General Materials Science ,Physical and Theoretical Chemistry ,Condensed Matter Physics - Published
- 2023
21. Functional two-dimensional black phosphorus nanostructures towards next-generation devices
- Author
-
Ye Zhang, Mengke Wang, Lanping Hu, Haiguo Hu, Weichun Huang, Jun Zhu, You Zi, Zhongjian Xie, and Zheng-Guang Wu
- Subjects
Nanostructure ,Materials science ,Renewable Energy, Sustainability and the Environment ,business.industry ,Charge carrier mobility ,Transistor ,Nanotechnology ,Heterojunction ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Black phosphorus ,0104 chemical sciences ,law.invention ,law ,General Materials Science ,Electronics ,Photonics ,0210 nano-technology ,business - Abstract
In recent years, two-dimensional (2D) black phosphorus (BP) has been widely applied in many fields, such as (opto)electronics, transistors, catalysis and biomedical applications due to its large surface area, tunable direct bandgap, superior charge carrier mobility, and unique in-plane anisotropic structure. To exploit its full potential and push the limits, studies on functional 2D BP nanostructures fabricated by a variety of methods, such as surface functionalization and hybridization, are rapidly expanding for next-generation devices with unprecedented properties. In this review, firstly, the synthetic techniques and fundamental properties of functional 2D BP nanostructures, including surface-modified 2D BP nanostructures and mixed-dimensional 2D BP-based heterostructures, are systematically summarized. Secondly, the recent progress of functional 2D BP nanostructures in the fields of energy storage and conversion, (opto) electronics, catalysis, sensors, nonlinear photonics, and biomedical applications is highlighted. Last but not least, the challenges and future opportunities in these emerging areas are discussed. We hope that this review can provide fundamental guidance on new designs of high-performance functional 2D BP nanostructures to meet the growing demand of next-generation devices.
- Published
- 2021
22. Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
- Author
-
Paramesh Jangili, Jun He, Jianlong Kang, Zhongjian Xie, Guohui Nie, Jong Seung Kim, Won Seok Choi, Ni Xie, Yunjie Xu, Liping Liu, Yanqi Ge, Yingwei Wang, Bin Zhang, Jianlei Xie, and Han Zhang
- Subjects
medicine.medical_treatment ,Photodynamic therapy ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Nanocomposites ,Nano formulation ,Neoplasms ,medicine ,Tumor cell death ,Animals ,Humans ,Severe pain ,Photosensitizer ,Photosensitizing Agents ,business.industry ,Tumor therapy ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Photochemotherapy ,Cancer research ,Combined therapy ,0210 nano-technology ,business ,Immune activation - Abstract
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability. It can be a promising treatment modality in several medical fields, including oncology, immunology, urology, dermatology, ophthalmology, cardiology, pneumology, and dentistry. Nevertheless, the clinical application of PDT is largely restricted by the drawbacks of traditional photosensitizers, limited tissue penetrability of light, inefficient induction of tumor cell death, tumor resistance to the therapy, and the severe pain induced by the therapy. Recently, various photosensitizer formulations and therapy strategies have been developed to overcome these barriers. Significantly, the introduction of nanomaterials in PDT, as carriers or photosensitizers, may overcome the drawbacks of traditional photosensitizers. Based on this, nanocomposites excited by various light sources are applied in the PDT of deep-seated tumors. Modulation of cell death pathways with co-delivered reagents promotes PDT induced tumor cell death. Relief of tumor resistance to PDT with combined therapy strategies further promotes tumor inhibition. Also, the optimization of photosensitizer formulations and therapy procedures reduces pain in PDT. Here, a systematic summary of recent advances in the fabrication of photosensitizers and the design of therapy strategies to overcome barriers in PDT is presented. Several aspects important for the clinical application of PDT in cancer treatment are also discussed.
- Published
- 2021
23. Long-Term Bioavailability of Single Doses of Intramuscular Vitamin D2
- Author
-
Lusha Li, Dexing Dai, Ruoman Sun, Chunlin Li, Xiaoping Xing, Xiangbing Wang, Feng Xu, Zhenming Liu, Xiaolin Lin, and Zhongjian Xie
- Subjects
Vitamin ,medicine.medical_specialty ,Vitamin D-binding protein ,business.industry ,Endocrinology, Diabetes and Metabolism ,chemistry.chemical_element ,030209 endocrinology & metabolism ,General Medicine ,Calcium ,Urinary calcium ,Bioavailability ,Bone remodeling ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Hypovitaminosis ,chemistry ,Internal medicine ,Healthy volunteers ,medicine ,030212 general & internal medicine ,business - Abstract
Objective: We sought to determine the long-term bioavailability of single doses of intramuscular (IM) vita-min D2 (D2) in healthy adults. Methods: Forty healthy volunteers with hypovitaminosis D received a single dose of 200,000, 400,000, or 600,000 IU intramuscular D2 or no treatment. Levels of 25-hydroxyvitamin D2 (25lOH]D2) and 25-hydroxyvitamin D3 (25lOH]D3) in serum were measured by liquid chromatography-tandem mass spectrometry. Vitamin D binding protein (DBP) and intact parathyroid hormone (iPTH), bone turnover markers (BTMs), and serum and urinary calcium were also measured. Results: After a single dose of D2 injection, the level of 25(OH)D2 increased slowly and reached a plateau at 8 weeks. The plateau remained stable for 12 weeks. The mean increase in 25(OH)D2 was 6.8, 9.6, or 15.6 ng/mL after injection of 200,000 IU, 400,000 IU, or 600,000 IU D2. Although endogenous 25(OH)D3 levels were reduced by IM D2, the total 25(OH)D levels increased by 5.0, 7.0, or 10.3 ng/mL in average after injection of 200,000 IU, 400,000 IU, or 600,000 IU D2. The iPTH levels were also decreased by IM D2. However, levels of serum calcium, BTMs, and DBP and urinary calcium were not altered by IM D2. Conclusion: A single dose of 200,000 IU, 400,000 IU, or 600,000 IU IM D2 raises total 25-hydroxyvitamin D levels by 5.0, 7.0, or 10.3 ng/mL on average for at least 12 weeks and reduces iPTH and endogenous 25(OH)D3 levels without affecting levels of serum calcium, BTMs, DBP, and urinary calcium.
- Published
- 2020
24. C/EBPβ mediates anti-proliferative effects of 1,25(OH)2D on differentiated thyroid carcinoma cells
- Author
-
Feng Xu, Yali Ling, Jingjing Yuan, Qin Zeng, Lusha Li, Dexing Dai, Xuedi Xia, Ruoman Sun, Ran Zhang, and Zhongjian Xie
- Subjects
Cancer Research ,Mice ,Endocrinology ,Oncology ,Endocrinology, Diabetes and Metabolism ,Animals ,Humans ,Receptors, Calcitriol ,Cell Differentiation ,Mice, SCID ,Thyroid Neoplasms ,Cell Proliferation - Abstract
Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy and highly expresses the receptor for 1,25-dihydroxyvitamin D (1,25(OH)2D). However, it is unclear whether 1,25(OH)2D regulates DTC proliferation and differentiation. Here, we found that 1,25(OH)2D3 inhibited proliferation but not differentiation of the DTC cells. Notably, CYP27B1was elevated in DTC cells and 25-hydroxyvitamin D3 (25(OH)D3) reduced DTC cell proliferation. Knockdown of VDR did not affect the anti-proliferative effects of 1,25(OH)2D3. However, knockdown of CCAAT enhancer-binding protein β (C/EBPβ)abolished 1,25(OH)2D3-suppressed DTC cell proliferation. In addition, 1,25(OH)2D3 induced phosphorylation and translocation of C/EBPβto the nucleus from the cytoplasm. However, inhibition of p38 mitogen-activated protein kinases (MAPK) abrogated 1,25(OH)2D3-induced phosphorylation and nuclear translocation of C/EBPβas well as 1,25(OH)2D3-suppressed DTC cell proliferation. Knockdown of C/EBPβreduced the expression of Notch3. Knockdown of Notch3 blocked 1,25(OH)2D3-suppressed DTC cell proliferation. In the DTC cell-derived xenograft SCID mouse, knockdown of C/EBPβmarkedly increased tumor growth and proliferation and decreased apoptosis. In DTC patients, C/EBPβwas predominantly located in the cytoplasm of DTC cells in the tumor tissue when compared with adjacent non-cancerous tissue in which C/EBPβis located in the nucleus. In conclusion, C/EBPβstimulated Notch3signaling via the p38 MAPK-dependent pathway mediates the inhibitory effect of 1,25(OH)2D on DTC cell proliferation.
- Published
- 2022
25. Tellurene Nanoflake-Based NO2 Sensors with Superior Sensitivity and a Sub-Parts-per-Billion Detection Limit
- Author
-
Heping Cui, Lu-Qi Tao, Hao Ren, Xianping Chen, Zhongjian Xie, Xiangyi Zhu, Xiandong Li, Han Zhang, Feng Zhang, Zeping Wang, Jiabing Yu, and Kai Zheng
- Subjects
Detection limit ,Materials science ,business.industry ,Parts-per notation ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Exfoliation joint ,0104 chemical sciences ,High surface ,Adsorption ,Electrical resistivity and conductivity ,Optoelectronics ,General Materials Science ,Density functional theory ,Sensitivity (control systems) ,0210 nano-technology ,business - Abstract
Industrial production, environmental monitoring, and clinical medicine put forward urgent demands for high-performance gas sensors. Two-dimensional (2D) materials are regarded as promising gas-sensing materials owing to their large surface-to-volume ratio, high surface activity, and abundant surface-active sites. However, it is still challenging to achieve facilely prepared materials with high sensitivity, fast response, full recovery, and robustness in harsh environments for gas sensing. Here, a combination of experiments and density functional theory (DFT) calculations is performed to explore the application of tellurene in gas sensors. The prepared tellurene nanoflakes via facile liquid-phase exfoliation show an excellent response to NO2 (25 ppb, 201.8% and 150 ppb, 264.3%) and an ultralow theory detection limit (DL) of 0.214 ppb at room temperature, which is excellent compared to that of most reported 2D materials. Furthermore, tellurene sensors present a fast response (25 ppb, 83 s and 100 ppb, 26 s) and recovery (25 ppb, 458 s and 100 ppb, 290 s). The DFT calculations further clarify the reasons for enhanced electrical conductivity after NO2 adsorption because of the interfacial electron transfer from tellurene to NO2, revealing an underlying explanation for tellurene-based gas sensors. These results indicate that tellurene is eminently promising for detecting NO2 with superior sensitivity, favorable selectivity, an ultralow DL, fast response-recovery, and high stability.
- Published
- 2020
26. Liquid-phase exfoliation of black sesame to create a nanoplatform for in vitro photoluminescence and photothermal therapy
- Author
-
Bing Wang, Ruitao Lu, Sha Li, Minhua Peng, Peigen Ren, Yao Zhu, Huixian Cui, Lin Kang, Taojian Fan, Zhongjian Xie, and Xiaoyun Liu
- Subjects
Photoluminescence ,Materials science ,Biocompatibility ,Biomedical Engineering ,Cancer therapy ,Medicine (miscellaneous) ,Liquid phase ,Bioengineering ,Nanotechnology ,02 engineering and technology ,Development ,Photothermal therapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Exfoliation joint ,0104 chemical sciences ,Nanomaterials ,Cell killing ,General Materials Science ,0210 nano-technology - Abstract
Aim: The present study aims to apply the facile liquid-phase exfoliation (LPE) strategy to fabricate 2D organic materials and thus to broaden the family of biocompatible and multifunctional 2D materials. Materials & methods: 2D material-organic melanin and cellulose nanosheets were synthesized from black sesame hull using LPE. Photoluminescence and photothermal properties of the nanosheets were assessed, as well as stability and cell killing ability. Results: The prepared 2D nanoplatform exhibited broad and multiple photoluminescent emission bands. It also demonstrated efficient photothermal cancer therapy with excellent biocompatibility. Conclusion: The present study could open an avenue in exfoliating organic materials using the LPE strategy. This could make the fabrication of multifunctional 2D organic materials more efficient and broaden the family of biocompatible 2D nanomaterials.
- Published
- 2020
27. Recent Advance of Tellurium for Biomedical Applications
- Author
-
Luxiao Chai, Hengliang Wang, Han Zhang, and Zhongjian Xie
- Subjects
Materials science ,chemistry.chemical_element ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Biological potential ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Nanomaterials ,chemistry ,Thermoelectric effect ,0210 nano-technology ,Tellurium - Abstract
Tellurium(Te) nanomaterials have aroused a wide interest in semiconductor, thermoelectric, piezoelectric, as well as biomedical applications. The last decades of reports indicated a major nanostructure of one-dimensional (1D) Te on account of its inherent structural anisotropy. Two-dimenional(2D) Te has been newly developed and drawn a lot of interests recently. This review presents the intrinsic biological potential of Te-based nanomaterials and summarizes their up-to-date advance in phototherapy and reactive oxygen species(ROS)-related applications in the biomedical field.
- Published
- 2020
28. Setting the new FRAX reference threshold without bone mineral density in Chinese postmenopausal women
- Author
-
R Chen, S Liu, Yangna Ou, N Ding, Zhongjian Xie, Q Wang, M Huang, Hui Liu, and Z Sheng
- Subjects
Bone mineral ,medicine.medical_specialty ,Hip fracture ,FRAX ,Postmenopausal women ,Receiver operating characteristic ,business.industry ,Endocrinology, Diabetes and Metabolism ,Radiography ,Osteoporosis ,030209 endocrinology & metabolism ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Osteoporotic fracture ,business - Abstract
Despite the large number of osteoporosis patients in China, the diagnosis and treatment rates remain low. The Fracture Risk Assessment Tool (FRAX) can be used to effectively evaluate fracture risk. In this study, we explored the Chinese-specific thresholds of FRAX without the T-score. In all, 264 postmenopausal women aged > 50 years were randomly recruited from community-medical centers. All subjects completed self-reported questionnaires, BMD measurements, and spinal radiographs. The 10-year hip and major osteoporotic fracture risks were calculated by FRAX. A new threshold for both 10-year hip and major osteoporotic fracture risk was explored with receiver operating characteristic (ROC) curve analysis. Overall, 92 subjects were diagnosed with osteoporosis. Among them, 14 participants with T-score > − 2.5 were diagnosed with osteoporosis based on clinical fractures. ROC analysis showed the cut-off value of the 10-year hip osteoporotic fracture for detecting osteoporosis was 0.95%, while that of 10-year major osteoporotic fracture was 4.95%. The sensitivity and specificity of the 10-year hip osteoporotic fracture probability for detecting osteoporosis were 0.86 and 0.59, respectively, while the guideline-recommended threshold had a sensitivity of 0.49 and specificity of 0.83. The sensitivity and specificity of the 10-year major osteoporotic fractures with the new threshold were 0.76 and 0.69, respectively, while the recommended threshold had a sensitivity of 0 and specificity of 1. Current guideline-recommended FRAX thresholds without BMD showed low sensitivity. Therefore, 10-year osteoporotic hip fracture probability ≥ 0.95% and 10-year osteoporotic major fracture probability ≥ 4.95% are recommended as the new thresholds.
- Published
- 2020
29. Recent advances in photodynamic therapy based on emerging two-dimensional layered nanomaterials
- Author
-
Han Zhang, Xinqiang Wu, Liangqi Cao, Dawei Zhang, Zhaoyuan Liu, Jiaqi Zhao, Qiwen Wang, Taojian Fan, Xiaofeng Jiang, Zhenhui Huang, Zhiwei Zheng, Zhongjian Xie, Zhijian Chen, Yu-bin Chen, and Ping Xue
- Subjects
Oxygen supply ,Materials science ,medicine.medical_treatment ,Nanotechnology ,Photodynamic therapy ,Tumor cells ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,eye diseases ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Light source ,polycyclic compounds ,medicine ,General Materials Science ,Photosensitizer ,Electrical and Electronic Engineering ,0210 nano-technology ,therapeutics - Abstract
Photodynamic therapy (PDT) is a promising non-invasive therapy approach for various diseases including malignant tumor. The process of PDT involves three interrelated aspects, namely photosensitizer (PS), light source, and oxygen, among which PS is the decisive factor that determines its anticancer efficiency. There exist some defects in currently applied PDT, such as inadequate production of reactive oxygen species (ROS), poor penetration of exciting light, insufficient oxygen supply, and nonselective distribution of PS. With unique physicochemical and optical properties, two-dimensional nanomaterials (2DNMs) have aroused great interest in biomedical fields. 2DNMs-based PDT is promising to significantly improve antitumor efficacy compared to conventional PDT. In this review, we will firstly introduce the underlying mechanism of PDT and how 2DNMs are absorbed and distribute inside tumor cells. After that, we will not only illustrate how 2DNMs-based PDT can enhance tumor-killing efficacy and minimize side-effects through conquering the above-mentioned defects of conventional PDT and the preparation process of 2DNMs, but also elaborate recent advances about 2DNMs-based PDT. Lastly, we will summarize the challenges and future prospects of 2DNMs-based PDT.
- Published
- 2020
30. Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions
- Author
-
Manavalan Rajesh Kumar, Ni Xie, Han Zhang, Guohui Nie, Guiqing Wang, Luxiao Chai, Aravindkumar Sundaram, Joice Sophia Ponraj, Xiangjiang Wang, Bin Zhang, Zhongjian Xie, and Ling Peng
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Engineered nanomaterials ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Cancer Medicine ,Neoplasms ,medicine ,Humans ,Nanotechnology ,General Materials Science ,Hypoxia ,Intensive care medicine ,business.industry ,Tumor therapy ,Hypoxia (medical) ,021001 nanoscience & nanotechnology ,Therapeutic modalities ,Nanostructures ,3. Good health ,0104 chemical sciences ,Radiation therapy ,medicine.symptom ,0210 nano-technology ,business - Abstract
In recent years, nanomaterials and nanotechnology have emerged as vital factors in the medical field with a unique contribution to cancer medicine. Given the increasing number of cancer patients, it is necessarily required to develop innovative strategies and therapeutic modalities to tackle hypoxia, which forms a hallmark and great barrier in treating solid tumors. The present review details the challenges in nanotechnology-based hypoxia, targeting the strategies and solutions for better therapeutic performances. The interaction between hypoxia and tumor is firstly introduced. Then, we review the recently developed engineered nanomaterials towards multimodal hypoxia tumor therapies, including chemotherapy, radiotherapy, and sonodynamic treatment. In the next part, we summarize the nanotechnology-based strategies for overcoming hypoxia problems. Finally, current challenges and future directions are proposed for successfully overcoming the hypoxia tumor problems.
- Published
- 2020
31. Progress in the therapeutic applications of polymer-decorated black phosphorus and black phosphorus analog nanomaterials in biomedicine
- Author
-
Bing Wang, Bin Zhang, Dong An, Chenyang Xing, Meng Qiu, Jianye Fu, and Zhongjian Xie
- Subjects
Bone Regeneration ,Polymer nanocomposite ,Theranostic Nanomedicine ,Polymers ,Neurogenesis ,Biomedical Engineering ,Antineoplastic Agents ,Nanotechnology ,Black phosphorus ,Nanocomposites ,Nanomaterials ,Calcification, Physiologic ,Drug Delivery Systems ,Neoplasms ,Animals ,Humans ,General Materials Science ,Bone regeneration ,Biomedicine ,Fluorescent Dyes ,chemistry.chemical_classification ,business.industry ,Drug Synergism ,Hydrogels ,Phosphorus ,General Chemistry ,General Medicine ,Polymer ,Phototherapy ,Drug Liberation ,chemistry ,Drug delivery ,Immunotherapy ,business - Abstract
Wonderful black phosphorus (BP) and some BP analogs (BPAs) have been increasingly studied for their biomedical applications owing to their fascinating properties and biodegradability, but opportunities and challenges have always coexisted in their study. Poor stability upon exposure to the natural environment is the major obstacle hampering their in vivo applications. BP/polymer and BPAs/polymer nanocomposites can not only efficiently prevent their oxidation and aggregation but also exhibit "biological activity" due to synergistic effects. In this review, we briefly describe the synthesis methods and stability strategies of BP/polymer and BPAs/polymer. Then, advances pertaining to their exciting therapeutic applications in various fields are systematically introduced, such as cancer therapy (phototherapy, drug delivery, and synergistic immunotherapy), bone regeneration, and neurogenesis. Some challenges for future clinical trials and possible directions for further study are finally discussed.
- Published
- 2020
32. Emerging 2D pnictogens for catalytic applications: status and challenges
- Author
-
Xiaobing Yan, Meng Qiu, Xiang Yu, Chenyang Xing, Han Zhang, Keqiang Chen, Zhongjian Xie, Ni Xie, Weichun Huang, Jianming Chen, and Weiyuan Liang
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Black phosphorus ,0104 chemical sciences ,Catalysis ,Characterization (materials science) ,Phosphorene ,chemistry.chemical_compound ,chemistry ,Electrical performance ,General Materials Science ,0210 nano-technology ,Pnictogen - Abstract
The exfoliation of phosphorene from black phosphorus to afford mono-elemental two-dimensional (2D) materials (Xenes) has caused a boom in various fields since 2014. Among the Xenes, an emerging class of material, 2D pnictogens, which includes phosphorene, arsenene, antimonene, and bismuthene, has drawn a great deal of attention in the field of catalysis owing to their high specific surface area, mechanical properties, biocompatibility, and optical and electrical performance. With the development of interdisciplinary research, it has become a new trend of scientific research, especially the application of catalysis in medicine, to break the barriers between disciplines and achieve multidisciplinary joint investigation. Herein, firstly, the structures, general properties, and synthetic methods of 2D pnictogen (group VA) materials are reviewed. Then, we summarize the various state-of-the-art catalytic applications of the 2D pnictogen family, such as photocatalysis, electrocatalysis, and medical catalysis, especially in terms of strategies to improve their catalytic performance, such as doping, functionalization, and heterostructures. We also shed some light on the cross-subject of photocatalytic and electrocatalytic processes for biomedical applications. Finally, we summarize the research progress, outlooks, and challenges for these 2D catalysts in terms of their catalytic performance, characterization, reaction mechanisms, exploration of new systems, and commercial applications. This review aims to highlight the catalytic effects of 2D pnictogen materials in enhancing the performance of reactions.
- Published
- 2020
33. Current status and prospects of memristors based on novel 2D materials
- Author
-
Han Zhang, Huide Wang, Ya-Pei Peng, Zhongjian Xie, Qianlong Zhao, Jingsheng Chen, Kaiyang Wang, Hongwei Wang, Xiangnan Li, and Xiaobing Yan
- Subjects
Hardware_MEMORYSTRUCTURES ,Neuromorphic engineering ,Mechanics of Materials ,law ,Computer science ,Process Chemistry and Technology ,Electronic engineering ,General Materials Science ,Memristor ,Electrical and Electronic Engineering ,Flexible electronics ,law.invention - Abstract
As promising non-volatile memory devices, memristors have received extensive attention since they can effectively mimic synapses and enable the fabrication of neuromorphic systems. In recent years, 2D materials have been widely used in memristors because of their unique advantages, which not only improve the performance of memristors, but also promote the applicability of memristors in flexible electronics, low-power high-temperature devices, neuromorphic computing, etc. In this review, we summarize the applications of 2D materials in fabricating memristors and their physical switching mechanisms. The challenges involved are discussed and the corresponding strategies are reviewed.
- Published
- 2020
34. Vitamin D receptor regulates proliferation and differentiation of thyroid carcinoma via the E-cadherin-β-catenin complex
- Author
-
Yali Ling, Feng Xu, Xuedi Xia, Dexing Dai, Ruoman Sun, and Zhongjian Xie
- Subjects
Endocrinology ,Cell Membrane ,Humans ,Receptors, Calcitriol ,Cell Differentiation ,Thyroid Neoplasms ,Vitamin D ,Cadherins ,Molecular Biology ,beta Catenin ,Cell Proliferation - Abstract
Thyroid cancer has the fastest rising incidence among cancers, especially for differentiated thyroid carcinoma (DTC). Although the prognosis of DTC is relatively good, if it changes to anaplastic thyroid carcinoma (ATC), the prognosis will be very poor. The prognosis of DTC is largely depending on the degree of cell differentiation and proliferation. However, whether the vitamin D receptor (VDR) plays a role in regulating the proliferation and the differentiation of DTC cells is unclear. In the present study, we found that VDR was upregulated in DTC tissues compared to the adjacent non-cancerous tissue. Knockdown of VDR increased proliferation and decreased differentiation proliferation in DTC cells in vitro as well as DTC cell-derived xenografts in vivo. In contrast, overexpression of VDR had an opposite effect. Knockdown of E-cadherin abolished VDR-induced suppression of proliferation and enhancement of differentiation of the DTC cells. Knockdown of β-catenin partially reversed the effect of the VDR knockdown. VDR increases the levels of E-cadherin in the plasma membrane and decreases the levels of β-catenin in the nucleus. VDR binds to E-cadherin and β-catenin in the plasma membrane of the DTC cell. Taken together, VDR inhibits DTC cell proliferation and promotes differentiation via regulation of the E-cadherin/β-catenin complex, potentially representing novel clues for a therapeutic strategy to attenuate thyroid cancer progression.
- Published
- 2022
35. Efficient Identification Method of Sugarcane Node Based on Linear Array Ccd Non-Contact Detection
- Author
-
CHUNMING WEN, ZHANPENG XIAO, YUNZHI YAN, YOUZONG HUANG, ZHONGJIAN XIE, and HONGLIANG NONG
- Published
- 2022
36. 2D Organic Materials: Status and Challenges
- Author
-
Xiaobing Yan, Ying Zhao, Gang Cao, Xiaoyu Li, Chao Gao, Luan Liu, Shakeel Ahmed, Faizah Altaf, Hui Tan, Xiaopeng Ma, Zhongjian Xie, and Han Zhang
- Subjects
General Chemical Engineering ,General Engineering ,General Physics and Astronomy ,Medicine (miscellaneous) ,General Materials Science ,Biochemistry, Genetics and Molecular Biology (miscellaneous) - Published
- 2023
37. Prevalent vertebral fractures among urban-dwelling Chinese postmenopausal women: a population-based, randomized-sampling, cross-sectional study
- Author
-
Weibo Xia, Qiang Liu, Jinhan Lv, Zhenlin Zhang, Wen Wu, Zhongjian Xie, Jianting Chen, Liang He, Jian Dong, Zhenming Hu, Qiang Lin, Wei Yu, Fang Wei, and Jue Wang
- Subjects
Postmenopause ,China ,Cross-Sectional Studies ,Urban Population ,Bone Density ,Hip Fractures ,Humans ,Osteoporosis ,Spinal Fractures ,Orthopedics and Sports Medicine ,Female ,Osteoporotic Fractures ,Aged - Abstract
Summary In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age ≥ 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high. Purpose To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study. Methods The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged ≥ 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant’s semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant’s score 1–3 and were analyzed using descriptive statistics. Results A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran–Armitage test p Conclusion VFs are prevalent among Chinese postmenopausal women who were ≥ 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis.
- Published
- 2021
38. Chemistry, Functionalization, and Applications of Recent Monoelemental Two-Dimensional Materials and Their Heterostructures
- Author
-
Zhongjian Xie, Guohui Nie, Han Zhang, Paras N. Prasad, Yanqi Ge, Yufeng Song, Bin Zhang, Yao Zhu, and Chang-Keun Lim
- Subjects
Rapid expansion ,Graphene ,Nanotechnology ,Heterojunction ,General Chemistry ,Catalysis ,law.invention ,Nonlinear optical ,Phosphorene ,chemistry.chemical_compound ,chemistry ,law ,Borophene ,Surface modification - Abstract
The past decades have witnessed a rapid expansion in investigations of two-dimensional (2D) monoelemental materials (Xenes), which are promising materials in various fields, including applications in optoelectronic devices, biomedicine, catalysis, and energy storage. Apart from graphene and phosphorene, recently emerging 2D Xenes, specifically graphdiyne, borophene, arsenene, antimonene, bismuthene, and tellurene, have attracted considerable interest due to their unique optical, electrical, and catalytic properties, endowing them a broader range of intriguing applications. In this review, the structures and properties of these emerging Xenes are summarized based on theoretical and experimental results. The synthetic approaches for their fabrication, mainly bottom-up and top-down, are presented. Surface modification strategies are also shown. The wide applications of these emerging Xenes in nonlinear optical devices, optoelectronics, catalysis, biomedicine, and energy application are further discussed. Finally, this review concludes with an assessment of the current status, a description of existing scientific and application challenges, and a discussion of possible directions to advance this fertile field.
- Published
- 2021
39. Recent advances in two-dimensional graphdiyne for nanophotonic applications
- Author
-
Yi Hu, Mengke Wang, Lanping Hu, Yulin Hu, Jia Guo, Zhongjian Xie, Songrui Wei, Yaohui Wang, You Zi, Han Zhang, Qiuliang Wang, and Weichun Huang
- Subjects
General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2022
40. Multi-enzyme activity nanozymes for biosensing and disease treatment
- Author
-
Li Su, Sainan Qin, Zhongjian Xie, Liang Wang, Karim Khan, Ayesha Khan Tareen, Defa Li, and Han Zhang
- Subjects
Inorganic Chemistry ,Materials Chemistry ,Physical and Theoretical Chemistry - Published
- 2022
41. A Regioselectively Oxidized 2D Bi/BiOx Lateral Nano-Heterostructure for Hypoxic Photodynamic Therapy
- Author
-
Chenchen Ge, Meng Gu, Wenli Bao, Zhongjian Xie, Hao Huang, Teng Yin, Meng Qiu, Hilliard L. Kutscher, Paras N. Prasad, Liping Liu, Zongze Wu, Han Zhang, Dou Wang, Qi Wang, Ni Xie, Shiyun Bao, and Bin Zhang
- Subjects
Materials science ,Photosensitizing Agents ,Mechanical Engineering ,medicine.medical_treatment ,Oxide ,Photodynamic therapy ,Nanotechnology ,Molecular engineering ,Nanomaterials ,Oxygen ,Electron transfer ,chemistry.chemical_compound ,chemistry ,Photochemotherapy ,Mechanics of Materials ,In vivo ,Neoplasms ,Nano ,medicine ,Tumor Microenvironment ,Humans ,General Materials Science ,Irradiation ,Hypoxia ,Bismuth - Abstract
Optoelectronic science and 2D nanomaterial technologies are currently at the forefront of multidisciplinary research and have numerous applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in these nanomaterials, enabled by their relative band alignment characteristics, can provide important therapeutic modalities for healthcare. Given that nano-heterostructures can facilitate photoinduced electron-hole separation and enhance generation of reactive oxygen species (ROS), 2D nano-heterostructure-based photosensitizers can provide a major advancement in photodynamic therapy (PDT), to overcome the current limitations in hypoxic tumor microenvironments. Herein, a bismuthene/bismuth oxide (Bi/BiOx)-based lateral nano-heterostructure synthesized using a regioselective oxidation process is introduced, which, upon irradiation at 660 nm, effectively generates 1 O2 under normoxia but produces cytotoxic •OH and H2 under hypoxia, which synergistically enhances PDT. Furthermore, this Bi/BiOx nano-heterostructure is biocompatible and biodegradable, and, with the surface molecular engineering used here, it improves tumor tissue penetration and increases cellular uptake during in vitro and in vivo experiments, yielding excellent oxygen-independent tumor ablation with 660 nm irradiation, when compared with traditional PDT agents.
- Published
- 2021
42. Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China
- Author
-
Xi-Yu Wu, Zhongjian Xie, Yi Shen, Xulei Tang, Ru-Chun Dai, Ling-Qing Yuan, Er-Yuan Liao, Songbo Fu, Li-hua Tan, Xian-Ping Wu, Hong-Li Li, and Zhi-Feng Sheng
- Subjects
musculoskeletal diseases ,Male ,China ,medicine.medical_specialty ,Fracture risk ,Osteoporosis ,Diseases of the musculoskeletal system ,Standard score ,Fractures, Bone ,Fragility ,Rheumatology ,Bone Density ,Internal medicine ,Bone mineral density ,medicine ,Humans ,Orthopedics and Sports Medicine ,T-score ,Bone mineral ,Lumbar Vertebrae ,Proportional hazards model ,business.industry ,Research ,Hazard ratio ,Anthropometry ,Fragility fracture ,medicine.disease ,RC925-935 ,Case-Control Studies ,Female ,business ,Body mass index - Abstract
Background Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched. Little is known about the relationship between BMD and fragility fracture risk of native Chinese, especially using local databases as reference databases. Objective To investigate relationship between BMD and risk of fragility fracture in native China. Methods 3,324 cases, including 2,423 women (67.7 ± 8.9 years) and 901 men (68.4 ± 11.6 years) having radiological fragility fractures and 3,324 age- and gender-matched controls participated in the study. We measured BMD at posteroanterior spine and hip using dual-energy X-ray absorptiometry (DXA), calculated BMD measurement parameters based on our own BMD reference database. Results BMDs and mean T-scores were lower in case group (with clinical fragility) than in control group (without clinical fragility). In patients with fragility fractures, prevalence of lumbar osteoporosis, low bone mass, and normal BMD were 78.9 %, 19.3 %, and 1.8 %, respectively, in women, and 49.5, 44.8 %, and 5.7 %, respectively, in men. In hip, these prevalence rates were 67.2 %, 28.4 %, and 4.4 % in females, and 43.2 %, 45.9 %, and 10.9 % in males, respectively, showing differences between females and males. Multivariate Cox regression analysis showed that after adjusting age, height, weight, and body mass index, fracture hazard ratio (HR) increased by 2.7–2.8 times (95 % CI 2.5–3.1) and 3.6–4.1 times (95 %CI 3.0–5.1) for women and men respectively with decreasing BMD parameters. In both sexes, risk of fragility fracture increased approximately 1.6–1.7 times (95 % CI 1.5–1.8) for every 1 T-score reduction in BMD. Conclusions Risk of clinical fragility fracture increases with decreasing BMD measurement parameters and anthropometric indicators in native China, and fracture HR varies from gender and site.
- Published
- 2021
43. Biocompatible Two-Dimensional Titanium Nanosheets for Multimodal Imaging-Guided Cancer Theranostics
- Author
-
Mengmeng Qu, Shiyun Bao, Han Zhang, Taojian Fan, Jinlai Zhao, Yao Zhu, Shiyou Chen, Liping Liu, Zhitao Lin, Dianyuan Fan, Yang Li, Zhongjian Xie, Hong Chen, Yanhong Duo, and Qingshuang Zou
- Subjects
Materials science ,Biocompatibility ,Cell Survival ,chemistry.chemical_element ,Photoacoustic imaging in biomedicine ,Nanotechnology ,02 engineering and technology ,Multimodal Imaging ,01 natural sciences ,Theranostic Nanomedicine ,Nanocomposites ,Nanomaterials ,Photoacoustic Techniques ,010309 optics ,Cell Line, Tumor ,0103 physical sciences ,medicine ,Humans ,General Materials Science ,Titanium ,Cancer ,Surface Plasmon Resonance ,Photothermal therapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Biocompatible material ,Combined Modality Therapy ,Nanostructures ,chemistry ,0210 nano-technology ,Localized surface plasmon - Abstract
Photothermal therapy (PTT) based on two-dimensional (2D) nanomaterials has shown significant potential in cancer treatment. However, developing 2D nanomaterial-based theranostic agents with good biocompatibility and high therapeutic efficiency remains a key challenge. Bulk titanium (Ti) has been widely used as biomedical materials for their reputable biocompatibility, whereas nanosized Ti with a biological function remains unexplored. In this work, the 2D Ti nanosheets (NSs) are successfully exfoliated from nonlayer bulk Ti and utilized as an efficient theranostic nanoplatform for dual-modal computed tomography/photoacoustic (CT/PA) imaging-navigated PTT. Besides the excellent biocompatibility obtained by TiNSs as expected, they are found to show strong absorption ability with an extinction coefficient of 20.8 L g-1 cm-1 and high photothermal conversion ability with an efficiency of 61.5% owing to localized surface plasmon resonances, which exceeds most of other well-known photothermal agents, making it quite promising for PTT against cancer. Furthermore, the metallic property and light-heat-acoustic transformation endow 2D Ti with the strong CT/PA imaging signal and efficient cancer therapy, simultaneously. This work highlights the enormous potential of nanosized Ti in both the diagnosis and treatment of cancer. As a paradigm, this study also paves a new avenue for the elemental transition-metal-based cancer theranostics.
- Published
- 2019
44. Effects of teriparatide in Chinese and Caucasian women with osteoporosis: bridging study on efficacy
- Author
-
Yun Chen, Fan Bai, Bin Zhang, Yujie Li, Zhongjian Xie, Sirel Gurbuz, and Yu Chen
- Subjects
Psychotherapist ,business.industry ,General Medicine ,Bridge (interpersonal) ,Bridging (programming) ,03 medical and health sciences ,0302 clinical medicine ,Teriparatide ,medicine ,030212 general & internal medicine ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objective To bridge the efficacy and compare the safety of the 24-week teriparatide treatment in a Chinese osteoporosis study ({"type":"clinical-trial","attrs":{"text":"NCT00414973","term_id":"NCT00414973"}}NCT00414973) to a large international trial (FPT, {"type":"clinical-trial","attrs":{"text":"NCT00670501","term_id":"NCT00670501"}}NCT00670501) to determine whether long-term results from the international study were applicable to Chinese patients.
- Published
- 2019
45. Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation
- Author
-
Qianwei Miao, Xudong Zhang, Xin Liang, Xinyu Ye, Lin Mei, Xiuli Chen, Chenyang Xing, Zhongjian Xie, Han Zhang, and Chao Wang
- Subjects
medicine.medical_treatment ,Pharmaceutical Science ,Apoptosis ,02 engineering and technology ,CD8-Positive T-Lymphocytes ,03 medical and health sciences ,Immune system ,Breast cancer ,Cancer immunotherapy ,Antigen ,In vivo ,Cell Line, Tumor ,Neoplasms ,Quantum Dots ,medicine ,Animals ,Humans ,030304 developmental biology ,Mice, Inbred BALB C ,0303 health sciences ,Chemistry ,Lasers ,Erythrocyte Membrane ,Phosphorus ,Dendritic Cells ,Immunotherapy ,Phototherapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Combined Modality Therapy ,Immune checkpoint ,Cancer cell ,Cancer research ,Female ,0210 nano-technology - Abstract
Basal-like breast cancer exhibits a triple-negative phenotype and has a poor prognosis, even with traditional chemical and anti-human epidermal growth factor receptor (HER) treatments. However, the high mutation rate of this obstinate cancer type renders it suitable for immunotherapy. Photothermal therapy (PTT) is a high-efficiency method for inducing tumor neoantigen release in situ, which has great potential for use in cancer immunotherapy. Here, we prepared a biomimetic black phosphorus quantum dot (BPQDs) formulation to induce breast cancer cell apoptosis in situ by near-infrared (NIR) laser irradiation to mobilize the immune system to eliminate the residual and metastatic cancer cells. Erythrocyte membranes (RMs) were used to coat the BPQDs, forming a BPQD-RM nanovesicle (BPQD-RMNV) biomimetic formulation that exhibited a long circulation time and tumor accumulation in vivo. The basal-like 4T1 breast tumor underwent apoptosis and necrosis with the irradiation and recruited dendritic cells (DCs) to capture the tumor antigens in vivo. Furthermore, programmed cell death protein 1 (PD-1) antibody (aPD-1) was employed to prevent the CD8+ T cells from exhaustion. Notably, BPQD-RMNV-mediated PTT combined with aPD-1 treatment significantly delayed residual and metastatic tumor growth in vivo. Hence, BPQD-RMNV-mediated PTT combined with immune checkpoint blockade antibody increased the infiltration and activity of CD8+ T cells in the tumor, which directly restrained basal-like breast tumor growth in vivo.
- Published
- 2019
46. New insights to atherosclerosis management: Role of nanomaterials
- Author
-
Zhongzhong Li, Cheng Jiang, Luxiao Chai, Taojian Fan, Chaozhou Li, Zhi Chen, Weichun Huang, Bin Zhang, Omar A. Al-Hartomy, Ahmed Al-Ghamdi, Swelm Wageh, Abdullah G. Al-Sehemi, Lin Kang, Quan Liu, Xiaoyun Liu, Qingshan Geng, Zhongjian Xie, and Han Zhang
- Subjects
General Materials Science - Published
- 2022
47. pH-responsive black phosphorus quantum dots for tumor-targeted photodynamic therapy
- Author
-
Qiwen Wang, Zijian Chen, Han Zhang, Zhaoyuan Liu, Ping Xue, Xiaofeng Jiang, Liangqi Cao, Wenting Li, Xinqiang Wu, Zhongjian Xie, and Dawei Zhang
- Subjects
Polyethylenimine ,Photosensitizing Agents ,Chemistry ,medicine.medical_treatment ,Biophysics ,Photodynamic therapy ,Phosphorus ,Dermatology ,Mononuclear phagocyte system ,Hydrogen-Ion Concentration ,Endocytosis ,Nanomaterials ,Cell membrane ,chemistry.chemical_compound ,medicine.anatomical_structure ,Oncology ,Photochemotherapy ,PEG ratio ,Quantum Dots ,medicine ,PEGylation ,Pharmacology (medical) - Abstract
Black phosphorus quantum dots(BPQDs) have shown a good application prospect in the field of tumor therapy due to their photoelectric effect and good biodegradability. Due to the active endocytosis and fast metabolic efficiency of tumor cells, BPQDs are easy to be absorbed by tumor cells. However, this does not guarantee that BPQDs will be completely targeted to tumor cells, and normal cells will also absorb BPQDs. Because the cell membrane is negatively charged, BPQDs are also negatively charged and are not easily absorbed by cells under the action of electrostatic repulsion. Surface pegylation is the most common modification method of black phosphorus at present. However, surface pegylation can reduce the uptake of BPQDs by tumor cells. Positive PEG is also easy to be recognized and swallowed by the reticuloendothelial system. The inherent instability and poor tumor targeting of BPQDs under physiological conditions limit further research and clinical application. For this purpose, we selected cationic polymer polyethylenimine (PEI) to modify BPQDs and then added RGD peptides targeting tumor cells. An outer layer of negatively charged PEG+DMMA makes the nanosystem more stable . In the acidic environment of the tumor, the PEG layer has a charge reversal, and the positively charged PEI and the RGD polypeptide BPQDs targeted by the tumor cells are released into the tumor cells. It provides a new method for efficiently and accurately transporting BPQDs, a novel photosensitive nanomaterial, into tumor cells for photodynamic therapy.
- Published
- 2021
48. Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis
- Author
-
Lei Qiu, Feng Xu, An Xiong, Zhongjian Xie, Ruoman Sun, Xuedi Xia, Yali Ling, and Dexing Dai
- Subjects
Male ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,Placebo ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Vitamin D ,Aged ,Aged, 80 and over ,Nutrition and Dietetics ,business.industry ,Incidence (epidemiology) ,Publication bias ,Vitamins ,Vitamin D Deficiency ,Confidence interval ,Meta-analysis ,Relative risk ,Dietary Supplements ,Accidental Falls ,Female ,business - Abstract
Summary Introduction Vitamin D supplementation has been widely recommended to prevent falls. However, considerable controversy exists regarding the association of such supplementation and fall risk. Previous meta-analyses yielded inconsistent results because of differences in the baseline of 25-hydroxyvitamin D [25(OH)D] and dose of vitamin D and use of vitamin D or in combination with calcium in different studies. Furthermore, some studies published recently were not included in the previous meta-analyses. Therefore, an updated and comprehensive meta-analysis is warranted. Methods We systematically searched several literature databases including PubMed and the Embase from inception to September 2020. The protocol for this meta-analysis was registered with PROSPERO (CRD42021226380). Randomized clinical trials (RCTs) reporting the effect of vitamin D supplementation alone or with calcium on fall incidence were selected from studies. Qualitative and quantitative information was extracted; the random-effects model was conducted to pool the data for fall; statistical heterogeneity was assessed using the I2 test and potential for publication bias was assessed qualitatively by a visual estimate of the funnel plot and quantitatively by calculation of the Begg's test and the Egger's test. Results Of the citations retrieved, 31 eligible studies involving 57 867 participants met inclusion criteria, reporting 17 623 falls. A total of 21 RCTs of vitamin D alone and 10 RCTs of vitamin D plus calcium were included in the meta-analysis. The meta-analysis of 21 RCTs (51 984 participants) of vitamin D supplementation alone (daily or intermittent doses of 400–60 000 IU) did not show a reduced risk of falls (The risk ratio [RR] 1.00, 95% confidence intervals [CI] 0.95 to 1.05) compared to placebo or no treatment. Subgroup analyses showed that the baseline of serum 25(OH)D concentration less than 50 nmol/L resulted in a reduction of fall risk (RR 0.77, 95% CI 0.61 to 0.98). In contrast, the meta-analysis of 10 RCTs (5883 participants) of combined supplementation of vitamin D (daily doses of 700–1000 IU) and calcium (daily doses of 1000–1200 mg) showed a 12% reduction in the risk of fall (RR 0.88, 95% CI 0.80 to 0.97). Conclusions The combination of vitamin D and calcium have beneficial effects on prevention falls in old adults. Although vitamin D supplementation alone has no effect on fall risk in old adults with 25(OH)D levels higher than 50 nmol/L, vitamin D supplementation alone does have a benefit on prevention of falls in old adults with 25(OH)D levels lower than 50 nmol/L.
- Published
- 2021
49. Comparison of the NOF and NOGG guidelines for spinal radiographic examination in postmenopausal Chinese women
- Author
-
Qin-Yi Wang, Rong Chen, Na Ding, Meng Huang, Hong Liu, Yangna Ou, Zhongjian Xie, Shu-Ying Liu, and Zhi-Feng Sheng
- Subjects
0301 basic medicine ,China ,medicine.medical_specialty ,Radiography ,Osteoporosis ,030209 endocrinology & metabolism ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Bone Density ,Internal medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Osteoporosis, Postmenopausal ,Femoral neck ,Bone mineral ,business.industry ,Guideline ,medicine.disease ,Height loss ,Postmenopause ,Menopause ,Cross-Sectional Studies ,medicine.anatomical_structure ,Orthopedic surgery ,Spinal Fractures ,Female ,030101 anatomy & morphology ,business - Abstract
The aim was to compare the National Osteoporosis Foundation (NOF) and the UK National Osteoporosis Guideline Group (NOGG) guidelines for the detection of vertebral fractures in postmenopausal Chinese women. The NOF guidelines had higher accuracy than the UK guidelines for spinal radiography examination. To compare the National Osteoporosis Foundation (NOF) and the UK National Osteoporosis Guideline Group (NOGG) guidelines for the detection of vertebral fractures in postmenopausal Chinese women. A cross-sectional study on 255 community-dwelling postmenopausal women was conducted in Hunan province in 2017. Demographic and clinical characteristics and risk factors were recorded through questionnaires. Height and weight were measured using standard methods, and bone mineral density (BMD) was measured with dual-energy X-ray absorptiometry. Vertebral fractures were diagnosed by radiography using semi-quantitative morphometry. The prevalence of vertebral fractures was 9.4%. Women with vertebral fractures were significantly older and shorter, had higher years-since menopause and height loss values and lower BMD and T-scores at the femoral neck and total hip, and were more likely to have a history of previous fractures. The sensitivity and specificity of the NOF guidelines were 91.7% and 39.8%, respectively, while the NOGG guidelines had lower sensitivity (87.5%) and specificity (32.5%). However, a higher percentage had indications for radiography in the 50-64 years age group according to the NOGG guidelines, while a higher percentage had indications for radiography in the ≥ 65 year group according to the NOF guidelines. The NOF guidelines were better than the NOGG guidelines for spinal radiography examination in the Chinese postmenopausal women.
- Published
- 2021
50. p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-γ1 signaling
- Author
-
Feng Xu, Daniel D. Bikle, Zhongjian Xie, Lusha Li, Shangli Ji, Yi Jiang, Zhenming Liu, Liyan Liao, and Chandrama Shrestha
- Subjects
0301 basic medicine ,cell proliferation and differentiation ,Physiology ,Clinical Biochemistry ,Medical Physiology ,Phospholipase ,chemistry.chemical_compound ,0302 clinical medicine ,squamous cell carcinoma cells ,2.1 Biological and endogenous factors ,Aetiology ,Cancer ,Gene knockdown ,Cell Differentiation ,Catenins ,phospholipase C-gamma 1 ,medicine.anatomical_structure ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,embryonic structures ,Carcinoma, Squamous Cell ,Immunohistochemistry ,Mouth Neoplasms ,phospholipase C-γ1 ,Signal Transduction ,Biochemistry & Molecular Biology ,animal structures ,Dietary ,Article ,03 medical and health sciences ,Rare Diseases ,medicine ,Phosphatidylinositol ,Dental/Oral and Craniofacial Disease ,Enhancer ,Cell Proliferation ,Phospholipase C ,Epidermal Growth Factor ,Cell growth ,Phospholipase C gamma ,Squamous Cell Carcinoma of Head and Neck ,Carcinoma ,Cell Biology ,p120-catenin ,Calcium, Dietary ,stomatognathic diseases ,030104 developmental biology ,chemistry ,Squamous Cell ,Cancer research ,Calcium ,Biochemistry and Cell Biology ,Digestive Diseases ,Nucleus - Abstract
p120-catenin (p120) serves as a stabilizer of the calcium-dependent cadherin-catenin complex and loss of p120 expression has been observed in several types of human cancers. The p120-dependent E-cadherin-β-catenin complex has been shown to mediate calcium-induced keratinocyte differentiation via inducing activation of plasma membrane phospholipase C-γ1 (PLC-γ1). On the other hand, PLC-γ1 has been shown to interact with phosphatidylinositol 3-kinase enhancerin the nucleus and plays a critical role in epidermal growth factor-induced proliferation of oral squamous cell carcinoma (OSCC) cells. To determine whether p120 suppresses OSCC proliferation and tumor growth via inhibiting PLC-γ1, we examined effects of p120 knockdown or p120 and PLC-γ1 double knockdown on proliferation of cultured OSCC cells and tumor growth in xenograft OSCC in mice. The results showed that knockdown of p120 reduced levels of PLC-γ1 in the plasma membrane and increased levels of PLC-γ1 and its signaling in the nucleus in OSCC cells and OSCC cell proliferation as well as xenograft OSCC tumor growth. However, double knockdown of p120 and PLC-γ1 or knockdown of PLC-γ1 alone did not have any effect. Immunohistochemical analysis of OSCC tissue from patients showed a lower expression level of p120 and a higher expression level of PLC-γ1 compared withthat of adjacent noncancerous tissue. These data indicate that p120 suppresses OSCC cell proliferation and tumor growth by inhibiting signaling mediated by nuclear PLC-γ1.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.