12 results on '"Shuangwu Feng"'
Search Results
2. Anti‐proliferative and metastasis‐inhibiting effect of carbon ions on non‐small cell lung adenocarcinoma A549 cells
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Zhen Yang, Hongtao Luo, Shuangwu Feng, Yichao Geng, Xueshan Zhao, Chengcheng Li, Ruifeng Liu, Qiuning Zhang, and Xiaohu Wang
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Oncology - Published
- 2022
3. Preliminary study on radiosensitivity to carbon ions in human breast cancer
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Yang Liu, Ruifeng Liu, Shuangwu Feng, Yichao Geng, Zhen Yang, Hongyan Li, Yarong Kong, Hongtao Luo, Hong Zhang, Qiuning Zhang, and Xiaohu Wang
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MDA-MB-231 ,Health, Toxicology and Mutagenesis ,Apoptosis ,Breast Neoplasms ,Radiation Tolerance ,Histones ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Radiation sensitivity ,Cell Line, Tumor ,Regular Paper ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiosensitivity ,Cyclin B1 ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,bcl-2-Associated X Protein ,030304 developmental biology ,Ions ,0303 health sciences ,Radiation ,Cell growth ,Chemistry ,Akt/mTOR/p70S6K pathway ,X-Rays ,Cell Cycle ,Ribosomal Protein S6 Kinases, 70-kDa ,Cell cycle ,Carbon ,carbon ions ,Proto-Oncogene Proteins c-bcl-2 ,radiosensitivity ,030220 oncology & carcinogenesis ,Cancer cell ,MCF-7 Cells ,Cancer research ,MCF-7 - Abstract
The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle distribution, cell apoptosis and protein expression levels [double-strand break marker γ-H2AX, cell cycle-related protein cyclin B1, apoptosis-related proteins Bax and Bcl-2, and the Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase B1 (p70S6K) pathway] were detected after irradiation with carbon ions or X-rays at doses of 0, 2, 4 and 8 Gy. Our results showed that the inhibition of cell proliferation and cell colony formation and the induction of G2/M phase arrest, DNA lesions and cell apoptosis/necrosis elicited by carbon ion irradiation were more potent than the effects elicited by X-ray radiation at the same dose. Simultaneously, compared with X-ray radiation, carbon ion radiation induced a marked increase in Bax and prominent decreases in cyclin B1 and Bcl-2 in a dose-dependent manner. Furthermore, the Akt/mTOR/p70S6K pathway was significantly inhibited by carbon ion radiation in both breast cancer cell lines. These results indicate that carbon ion radiation kills MDA-MB-231 and MCF-7 breast cancer cells more effectively than X-ray radiation, which might result from the inhibition of the Akt/mTOR/p70S6K pathway.
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- 2020
4. Comparison of total endoscopic thyroidectomy with conventional open thyroidectomy for treatment of papillary thyroid cancer: a systematic review and meta-analysis
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Chun-Lin Zhao, Peijing Yan, Wen-Jie Jiang, Tiankang Guo, Hongwei Tian, Caiwen Han, Kehu Yang, Wen Tian, Yan-Jun Zhang, Shuangwu Feng, Jia Yang, and Moubo Si
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Cochrane Library ,Papillary thyroid cancer ,medicine ,Humans ,Hypocalcaemia ,Thyroid Neoplasms ,Thyroid cancer ,business.industry ,Thyroid ,Thyroidectomy ,Endoscopy ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Thyroid Cancer, Papillary ,Meta-analysis ,Female ,business ,Abdominal surgery - Abstract
Despite the fact that thyroid surgery has evolved towards minimal incisions and endoscopic approaches, the role of total endoscopic thyroidectomy (TET) in thyroid cancer has been highly disputed. We performed a systematic review and meta-analyses of peer reviewed studies in order to evaluate the safety and effectiveness of TET compared with conventional open thyroidectomy (COT) in papillary thyroid cancer (PTC). Medical literature databases such as PubMed, Embase, the Cochrane Library, and Web of science were systematically searched for articles that compared TET and COT in PTC treatment from database inception until March 2019. The quality of the studies included in the review was evaluated using the Downs and Black scale using Review Manager software Stata V.13.0 for the meta-analysis. The systematic review and meta-analysis were based on 5664 cases selected from twenty publications. Criteria used to determine surgical completeness included postoperative thyroglobulin (TG) levels, recurrence of the tumor after long-term follow-up. Adverse event and complication rate scores included transient recurrent laryngeal nerve (RLN) palsy, permanent RLN palsy, transient hypocalcaemia, permanent hypocalcaemia, operative time, number of removed lymph nodes, length of hospital stay and patient cosmetic satisfaction. TET was found to be generally equivalent to COT in terms of surgical completeness and adverse event rate, although TET resulted in lower levels of transient hypocalcemia (OR 1.66; p
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- 2020
5. Mechanism of Asbt (Slc10a2)-related bile acid malabsorption in diarrhea after pelvic radiation
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Xiaohu Wang, Xueshan Zhao, Yichao Geng, Shuangwu Feng, Lina Wang, Xiaoming Hou, Yan Zhou, Qiuning Zhang, Bin Guo, Juntao Ran, Chengcheng Li, and Guangwen Zhang
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SLC10A2 ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,biology ,Mechanism (biology) ,Genitourinary system ,business.industry ,Bile acid malabsorption ,medicine.disease ,Gastroenterology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Diarrhea ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,biology.protein ,Radiology, Nuclear Medicine and imaging ,medicine.symptom ,business ,Pelvic radiotherapy - Abstract
Background: Radiation is a mode of treatment for many pelvic malignancies, most of which originate in the gynecologic, gastrointestinal, and genitourinary systems. However, the healthy gut is unavo...
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- 2020
6. Stereotactic body radiation therapy or surgery for stage I–II non-small cell lung cancer treatment?—outcomes of a meta-analysis
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Qiuning, Zhang, Lihua, Shao, Jinhui, Tian, Ruifeng, Liu, Yichao, Geng, Yiran, Liao, Hongtao, Luo, Long, Ge, Shuangwu, Feng, Xiaohu, Wang, and Zhen, Yang
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surgery ,Meta-analysis ,Cancer Research ,stage I/II non-small cell lung cancer (NSCLC) ,stereotactic body radiotherapy (SBRT) ,Oncology ,Original Article ,Radiology, Nuclear Medicine and imaging ,stereotactic ablative radiotherapy (SABR) - Abstract
Background Stereotactic body radiotherapy (SBRT) has been increasingly recognized as a favourable alternative to surgical resection for early-stage non-small cell lung cancer (NSCLC). Many retrospective analyses compared the efficacy of SBRT with that of surgery for NSCLC. However, the difference in efficacy between SBRT and surgery in patients with early-stage NSCLC remains unclear. Methods We searched PubMed, the Cochrane Library, EMBASE and the Chinese Biomedical Literature Database from inception to March 14, 2018, to identify studies comparing SBRT with surgery in the treatment of stage I/II NSCLC. STATA 12.0 software was used to perform the meta-analysis. Results A total of 15 studies that carried out propensity score matching (PSM) were included. In this meta-analysis, patients with SBRT had worse overall survival (OS) than those with surgery, but the analysis restricting studies to the same adjustment factors showed that the difference in OS gradually decreased with the increase in comparable matching characteristics between the two groups and that there was eventually no significant difference. Patients treated with SBRT achieved similar cause-specific survival (CSS), local control, regional control, loco-regional control, and distant control compared with surgery. In addition, a separate analysis of 6 studies that compared SBRT with lobectomy also showed that with the increase in comparable matching characteristics between surgery and SBRT, the OS differences gradually decreased, and there was eventually no significant difference. Conclusions In this study, we found more favourable OS for stage I/II NSCLC treated with surgery, but when there were increasing numbers of comparable matching characteristics between surgery and SBRT, the differences in the survival rate were reduced to the point that they were not significant. The CSS and recurrence (local, regional, or disseminated) differences between surgery and SBRT were also not significant. Therefore, SBRT has the potential to be an alternative to surgical treatment in patients with stage I/II NSCLC, but these findings need to be confirmed by large-sample, long-term follow-up randomized clinical studies.
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- 2019
7. The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review
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Xueshan Zhao, Yan Ma, Chengcheng Li, Juntao Ran, Shuangwu Feng, Zheng Li, Qiuning Zhang, Yichao Geng, Xiaoming Hou, Xiaohu Wang, Guangwen Zhang, Zheng Yang, and Lina Wang
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Diarrhea ,Flora ,medicine.medical_specialty ,medicine.medical_treatment ,R895-920 ,Review ,Gut flora ,Cochrane Library ,Gastroenterology ,Pelvis ,Medical physics. Medical radiology. Nuclear medicine ,Internal medicine ,medicine ,Radiation Enteritis ,Carcinoma ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiation Injuries ,Gastrointestinal microbiome ,RC254-282 ,biology ,Radiotherapy ,business.industry ,Gastrointestinal Microbiome ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,biology.organism_classification ,medicine.disease ,Diarrhoea ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Systematic review ,business - Abstract
Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radiation field is inevitably damaged, a phenomenon clinically referred to as radiation enteritis, and diarrhoea is the most common clinical symptom of radiation enteritis. Therefore, it is necessary to study the mechanism of radiation-induced diarrhoea. It has been found that the gut microbiome plays an important role in the development of diarrhoea in response to pelvic radiotherapy, and the species and distribution of intestinal microbiota are significantly altered in patients after pelvic radiotherapy. In this study, we searched for articles indexed in the Cochrane Library, Web of Science, EMBASE and PubMed databases in English and CNKI, Wanfang data and SINOMED in Chinese from their inception dates through 13 March 2020 to collect studies on the gut microbiome in pelvic radiotherapy patients. Eventually, we included eight studies: one study report on prostatic carcinoma, five studies on gynaecological carcinoma and two papers on pelvic carcinomas. All studies were designed as self-controlled studies, except for one that compared toxicity to nontoxicity. The results from all the studies showed that the diversity of intestinal flora decreased during and after pelvic radiotherapy, and the diversity of intestinal flora decreased significantly in patients with diarrhoea after radiotherapy. Five studies observed that the community composition of the gut microbiota changed at the phylum, order or genus level before, during, and after pelvic radiotherapy at different time points. In addition, the composition of the gut microbiota before radiotherapy was different between patients with postradiotherapy diarrhoea and those without diarrhoea in five studies. However, relevant studies have not reached consistent results regarding the changes in microbiota composition. Changes in the intestinal flora induced by pelvic radiotherapy and their relationship between changes in intestinal flora and the occurrence of radiation-induced diarrhoea (RID) are discussed in this study, providing a theoretical basis for the causes of RID after pelvic radiotherapy.
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- 2021
8. Safety and Efficacy of PD-1/PD-L1 inhibitors combined with radiotherapy in patients with non-small-cell lung cancer: a systematic review and meta-analysis
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Yichao Geng, Zheng Li, Xueshan Zhao, Lina Wang, Qiuning Zhang, Xiaohu Wang, Shuangwu Feng, Chengcheng Li, Ruifeng Liu, Zhen Yang, Hongtao Luo, and Bing Lu
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0301 basic medicine ,Oncology ,combined radio‐immunotherapy ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Combination therapy ,medicine.medical_treatment ,Programmed Cell Death 1 Receptor ,Radiosurgery ,lcsh:RC254-282 ,B7-H1 Antigen ,03 medical and health sciences ,0302 clinical medicine ,systematic review ,Internal medicine ,Carcinoma, Non-Small-Cell Lung ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Lung cancer ,Adverse effect ,Immune Checkpoint Inhibitors ,non‐small‐cell lung cancer ,radiotherapy ,Pneumonitis ,Randomized Controlled Trials as Topic ,Original Research ,business.industry ,Clinical Cancer Research ,Odds ratio ,Chemoradiotherapy ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Combined Modality Therapy ,programmed cell death protein‐1/programmed cell death ligand‐1 inhibitors ,Clinical trial ,Radiation therapy ,Survival Rate ,030104 developmental biology ,meta‐analysis ,030220 oncology & carcinogenesis ,Immunotherapy ,business - Abstract
Background A combination of programmed cell death protein‐1 (PD‐1)/programmed cell death ligand‐1 (PD‐L1) inhibitors and radiotherapy (RT) is increasingly being used to treat non‐small‐cell lung cancer (NSCLC). However, the safety and efficacy of this approach remains controversial. We performed a systematic review and meta‐analysis to summarize the related research. Methods We searched the China Biology Medicine, EMBASE, Cochrane Library, and PubMed databases for all the relevant studies. The Stata software, version 12.0 was used for the meta‐analysis. Results The study included 20 clinical trials that enrolled 2027 patients with NSCLC. Compared with non‐combination therapy, combination therapy using PD‐1/PD‐L1 inhibitors and RT was associated with prolonged overall survival (OS) (1‐year OS: odds ratio [OR] 1.77, 95% confidence interval [CI] 1.35–2.33, p = 0.000; 2‐year OS: OR 1.77, 95% CI 1.35–2.33, p = 0.000) and progression‐free survival (PFS) (0.5‐year PFS: OR 1.83, 95% CI 1.13–2.98, p = 0.014; 1‐year PFS: OR 2.09, 95% CI 1.29–3.38, p = 0.003; 2‐year PFS: OR 2.47, 95% CI 1.13–5.37, p = 0.023). Combination therapy also improved the objective response rate (OR 2.76, 95% CI 1.06–7.19, p = 0.038) and disease control rate (OR 1.80, 95% CI 1.21–2.68, p = 0.004). This meta‐analysis showed that compared with non‐combination therapy, combination therapy using PD‐1/PD‐L1 inhibitors and RT did not increase the serious adverse event rates (≥grade 3); however, this approach increased the rate of grade 1–2 immune‐related or radiation pneumonitis. Subgroup analyses revealed that the sequence of PD‐1/PD‐L1 inhibitors followed RT outperformed in which concurrent PD‐1/PD‐L1 inhibitor and RT followed PD‐1/PD‐L1 inhibitor. Combination of stereotactic body RT or stereotactic radiosurgery with PD‐1/PD‐L1 inhibitors may be more effective than a combination of conventional RT with PD‐1/PD‐L1 inhibitors in patients with advanced NSCLC. Conclusion Combination therapy using PD‐1/PD‐L1 inhibitors and RT may improve OS, PFS, and tumor response rates without an increase in serious adverse events in patients with advanced NSCLC. However, combination therapy was shown to increase the incidence of mild pneumonitis., Radiotherapy combined with PD‐1/PD‐L1 inhibitors in the treatment of advanced NSCLC showed clinical long‐term survival benefit and short‐term efficacy benefit, and might not increase the serious adverse events.
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- 2020
9. Induction chemotherapy followed by neoadjuvant chemoradiotherapy and surgery for patients with locally advanced rectal cancer: a systematic review and meta-analysis
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Zhen Yang, Xueshan Zhao, Lina Wang, Xiaohu Wang, Peijing Yan, Qiuning Zhang, Zheng Li, Hong-Yi Cai, Chengcheng Li, Shuangwu Feng, and Yichao Geng
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medicine.medical_specialty ,China ,Colorectal cancer ,medicine.medical_treatment ,Locally advanced ,Cochrane Library ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,parasitic diseases ,medicine ,Humans ,Neoadjuvant therapy ,business.industry ,Rectal Neoplasms ,Incidence (epidemiology) ,Gastroenterology ,Induction chemotherapy ,Chemoradiotherapy ,Chemoradiotherapy, Adjuvant ,Induction Chemotherapy ,Hepatology ,medicine.disease ,Neoadjuvant Therapy ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Meta-analysis ,030211 gastroenterology & hepatology ,Neoplasm Recurrence, Local ,business - Abstract
Controversy persists about whether additional induction chemotherapy (ICT) before neoadjuvant chemoradiation (NCRT) yields improved oncological outcomes. We performed a systematic review and meta-analysis to compare ICT+ NCRT+ surgery(S) with NCRT+ S in patients with locally advanced rectal cancer (LARC). We searched the PubMed, EMBASE, Cochrane Library, and China Biology Medicine (CBM) databases. The data were analyzed with Stata version 12.0 software. We identified 9 relevant trials that enrolled 1538 patients. We detected no significant difference in the 5-year overall survival (OS) (OR 1.50, 95% CI 0.48–4.64), disease-free survival (DFS) (OR 1.03, 95% CI 0.73–1.46), local recurrence (LR) (OR 0.80, 95% CI 0.45–1.43), and distant metastasis (DM) rates (OR 1.03, 95% CI 0.55–1.93) between patients who did and did not receive ICT. The addition of ICT before NCRT had a similar pathological complete response rate compared to NCRT (OR 1.26, 95% CI 0.90–1.77). Our findings suggest that between the ICT + NCRT+S and NCRT+S groups, ICT improved the incidence of grade 3 to 4 toxicity effects (OR 4.81, 95% CI 2.38–9.37), but between the ICT + NCRT+S and NCRT+S+ adjuvant chemotherapy (ACT) groups, ICT might reduce toxicity (OR 0.19, 95% CI 0.08–0.50). ICT had no significant impact on surgical complications (OR 0.97, 95% CI 0.63–1.51). The addition of ICT before NCRT seemingly shows no survival benefit on patients with LARC, and might increase the toxicity.
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- 2020
10. Effects of DRP1 on tumor metastasis: a systematic review
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Chengcheng Li, Yang Liu, Xueshan Zhao, Yichao Geng, Lina Wang, Kehu Yang, Shuangwu Feng, Zheng Li, Qiuning Zhang, and Xiaohu Wang
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business.industry ,Cancer research ,Medicine ,business ,medicine.disease ,Metastasis - Published
- 2020
11. Mechanism of Asbt (
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Lina, Wang, Yan, Zhou, Xiaohu, Wang, Guangwen, Zhang, Bin, Guo, Xiaoming, Hou, Juntao, Ran, Qiuning, Zhang, Chengcheng, Li, Xueshan, Zhao, Yichao, Geng, and Shuangwu, Feng
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Bile Acids and Salts ,Diarrhea ,Male ,Rats, Sprague-Dawley ,Symporters ,Cholestyramine Resin ,Animals ,Organic Anion Transporters, Sodium-Dependent ,Radiation Injuries ,Steatorrhea ,Pelvis ,Rats - Published
- 2020
12. Is there a role for carbon therapy in the treatment of gynecological carcinomas? A systematic review
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Yichao Geng, Xueshan Zhao, Shuangwu Feng, Chengcheng Li, Juntao Ran, Qiuning Zhang, Xiaohu Wang, and Lina Wang
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0301 basic medicine ,Carbon therapy ,Oncology ,Cancer Research ,medicine.medical_specialty ,Genital Neoplasms, Female ,Heavy Ion Radiotherapy ,03 medical and health sciences ,0302 clinical medicine ,Concurrent chemotherapy ,Internal medicine ,medicine ,Humans ,Surgical treatment ,Clinical Trials as Topic ,Genitourinary system ,business.industry ,Melanoma ,Disease Management ,General Medicine ,medicine.disease ,Clinical trial ,030104 developmental biology ,Treatment Outcome ,030220 oncology & carcinogenesis ,Carbon ion therapy ,Carbon Ion Radiotherapy ,Female ,business - Abstract
This Systematic Review summarizes the literatures of clinical trials on the efficacy and safety of carbon ion therapy for gynecological carcinomas. The protocol is detailed in the online PROSPERO database, registration no. CRD42019121424, and a final set of eight studies were included. In the treatment of cervical carcinomas, both carbon ion therapy alone and carbon ion therapy concurrent chemotherapy have presented good efficacy. Besides, the efficacy of inoperable endometrial carcinomas and gynecological melanoma are similar to that of surgical treatment. In terms of safety, gastrointestinal and genitourinary toxicities are low and could be controlled by limiting the volume and dose of intestinal tract and bladder. Carbon ion radiotherapy could be considered a safe, effective and feasible therapy for gynecological carcinomas.
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- 2019
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