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1. [Comparative characteristic of energy supply disturbances in arterial and venous walls of rabbits with alloxan diabetes and monoiodacetate intoxication].

Author

Ataman OV and Ataman IuO

Subjects
Adenosine Triphosphate metabolism, Alloxan, Animals, Aorta, Thoracic drug effects, Diabetes Mellitus, Experimental physiopathology, Glucose metabolism, Lactic Acid metabolism, Male, Monckeberg Medial Calcific Sclerosis metabolism, Oxygen Consumption drug effects, Rabbits, Venae Cavae drug effects, Aorta, Thoracic metabolism, Diabetes Mellitus, Experimental metabolism, Energy Metabolism drug effects, Iodoacetic Acid toxicity, Venae Cavae metabolism
Abstract

We showed here that energy metabolism in thoracic rabbit aorta and posterior vena cava is disturbed two weeks following the induction of alloxan-induced diabetes and monoiodacetate intoxication. In the vessels studied, the alterations are manifested in the decrease in the intensity of glucose uptake, oxygen consumption, lactic acid production, and ATP resynthesis. Simultaneously, the ATP content is significantly reduced. The possible significance of these disorders in the development of Monckeberg's arteriosclerosis is discussed.

Published
2011

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