1. [Modeling of experimental allergic encephalomyelitis in rats and immunomodulation with allogeneic brain cells].
- Author
-
Lisianyĭ MI, Markova OV, and Bel's'ka LM
- Subjects
- Animals, Animals, Newborn, Brain immunology, Encephalomyelitis, Autoimmune, Experimental etiology, Freund's Adjuvant administration & dosage, Freund's Adjuvant immunology, Immunization, Immunotherapy methods, Neuroglia immunology, Neurons immunology, Rats, Spinal Cord immunology, Brain cytology, Brain Tissue Transplantation, Encephalomyelitis, Autoimmune, Experimental immunology, Encephalomyelitis, Autoimmune, Experimental therapy, Neuroglia transplantation, Neurons transplantation, Transplantation, Homologous
- Abstract
We studied the immunocorrective effect of the allogenic new-born brain cells on the model of rats experimental allergic encephalomyelitis (EAE). EAE was induced by the immunization of old rats spinal cord homogenate in Freund's adjuvant. Correction was carried on the 12-th, 14-th, 16-th day after the induction of the EAE by the intraperitoneum injection of rat's new-born brain fractions enriched with neurons and glial cells. A positive clinical effect was achieved by the employment of neurons (the stabilization of encephalomyelitis and the acceleration of the recovery). The glia correction was accompanied by the aggravation in the course of encephalomielitis and by extension of its clinical manifestation period. The obtained results testify to the existence of both an immunoregulative and a neurotrophic influence of the neuron fraction of the new-born brain cells. The mechanism of a corrective effect needs further special investigation.
- Published
- 2001