1. [Immunomodulatory effects of vitamin D3 and bisphosphonates in nutritional osteoporosis in rats].
- Author
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Riasnyĭ VM, Apukhovs'ka LI, Velykyĭ MM, Shymans'kyĭ IO, Labudzyns'kyĭ DO, and Komisarenko SV
- Subjects
- Animals, B-Lymphocytes drug effects, B-Lymphocytes immunology, Bone Density Conservation Agents therapeutic use, Bone and Bones drug effects, Bone and Bones immunology, Calcifediol blood, Calcifediol immunology, Calcium blood, Cholecalciferol therapeutic use, Diphosphonates therapeutic use, Drug Combinations, Flow Cytometry, Granulocytes drug effects, Granulocytes immunology, Immunoglobulins biosynthesis, Immunoglobulins drug effects, Immunomodulation drug effects, Male, Monocytes drug effects, Monocytes immunology, Osteoporosis blood, Osteoporosis prevention & control, Phagocytosis drug effects, Phagocytosis immunology, Rats, Rats, Wistar, Bone Density Conservation Agents administration & dosage, Cholecalciferol administration & dosage, Diphosphonates administration & dosage, Immunity, Humoral drug effects, Osteoporosis immunology
- Abstract
The aim of this study was to determine the effectiveness of separate and combined administration of vitamin D3 and different forms of bisphosphonate (disodium salt of methylenbisphosphonic acid dihydrate and alendronate) on the function of immune cells in rats with nutritional osteoporosis. It was shown that D-hypovitaminosis leads to reduced 25OHD3, which is a biomarker for vitamin D3 and disturbances of metabolic processes in bone tissue that correlated with osteoporosis manifestation. Immunologic disorders related to nutritional osteoporosis were accompanied by the decrease in phagocytic activity of granulocytes and impaired ability to produce bactericidal oxidants. Inhibition of B-cell immunity also occurred in patholgy. Thus, the present study revealed more pronounced immunomodulatory effects of vitamin D3 on phagocytic immunity, whereas bisphosphonates were effective in improving the humoral immune protection.
- Published
- 2012