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8 results on '"Oncopathology"'

1. Mechanisms of stress-overcoming behavior in women with oncopathology

Author

Bohdan Stanovskiy

Subjects
oncopathology, psycho-oncology, stress coping behavior, stress coping, women, psychosomatics, Education, Sports, GV557-1198.995, Medicine
Abstract

The article describes the empirical research of the features of stress coping behavior in patients with newly diagnosed oncopathology. The author's attention is directed to the analysis of the chronic social stress impact on the psychological state of women with cancer due to its relevance in modern social conditions. The article highlights the hypothesis that the effectiveness of stress coping behavior and the general psychological state of patients are closely related to the quality and specificity of provided psychological support. Particular attention is paid to the study of the connection between individual strategies for stress coping and social factors, in particular, family support, dealing with friends and medical personnel. The research is based on an interdisciplinary approach, including knowledge from medicine, psychology, sociology, and other fields for a deeper understanding of the mechanisms of stress coping behavior in patients with oncology and the development of a comprehensive support strategy considering a wide range of factors: from individual characteristics to social living conditions. The conclusions of the empirical study are important for the practice of medical psychology and further research in the field of psycho-oncology.

Published
2023
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2. Medical and geographical determinants of oncopathology in the population

Author

M. P. Hrebniak, O. V. Kirsanova, V. V. Taranov, and N. H. Mikriukova

Subjects
medical geography, oncopathology, irradiation, Pharmacy and materia medica, RS1-441
Abstract

The aim: to study the permanent risk factor of oncopathology in order to determine its medical and geographical features and assess their impact on oncopathology of the population of Zaporizhzhia region. Materials and methods. By means of spatial and geographical, as well as analytical and statistical methods, territories were medically and statistically differentiated, with the assessment of the natural environment quality. Epidemiological study of malignant neoplasms was conducted retrospectively for the period of 2004–2015, in accordance with the International Classification of Diseases ICD-10. Determination of environmental impact on oncopathology was performed using the attributive fraction. Results. Geoactive space is characterized by a variety of natural and climatic conditions of lithosphere, hydrosphere and landscapes. The main physical and geographical objects of the Zaporizhzhia region (Ukrainian Crystal Shield, the Dnipro, the Sea of Azov) form six zones, which differ in the diversity of system-forming elements. Specific features of discontinuous disturbances of the lithosphere of the Ukrainian crystal shield are abnormally high electrical conductivity of the earth’s crust, intense electromagnetic fields, high concentration of radon in aquifers, and streams of high-energy fluids. Conclusions. The highest geopathogenic impact is manifested in the fault zone of the Ukrainian crystal shield. The highest values of the attributive fraction of malignant neoplasms were registered in this zone among the whole population (26.8 %), among the adult population (25.4 %) and the able-bodied population (32.7 %). The oncopathological potential of natural conditions was least manifested in the valley of the Dnipro breakthrough and the Azov Upland, where the attributive fraction for almost all indicators did not exceed 8.2 %.

Published
2021
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3. MULTITARGET ANTI-PD-1/PD-L1/CD19/CD25/CD38 THERAPY USING CHELATE NANOCOMPLEX MSC-428 IN ONCOPATHOLOGY

Author

Lukyanchuk O. V., Artemov A. V., and Buryachkovsky E. S.

Subjects
multitarget therapy, nanocomplexes, oncopathology, Medicine, Biology (General), QH301-705.5
Abstract

Over the past decade, there has been a deepening of ideas about the relationship between the tumor and the hosts immune system, as evidenced by the 2018 Nobel Prize in medicine and physiology for studying the role of the so-called. Immune checkpoints in neoplasm care from an attack of the hosts immune system. This mechanism is associated with the appearance on the surface of tumor cells of specific proteins PD-1/PD-L-1, which prevent contact with the killer lymphocyte receptor. Chelate nanocomplexes (MSC-428) target PD-1/PD-L-1, i. e. affect the immune checkpoints directly. MSC-428 molecules attack 4 target proteins: PD-1/PD-L1, CD19, CD25, CD38, which leads to the normalization of surface antigens CD3, CD4, CD8, CD16, CD45, CD95 lymphocytes, phagocytosis systems and immunoglobulins of class A, M, G. The proposed strategy of treatment against PD-1/PD-L-1 with the use of metal-containing nanocomplex MSC428 expands the possibilities of influencing immune checkpoints. Through conformational change in the 3-dimensional structure of the receptor proteins PD-1, the drug prevents them from binding to PD-L1 in tumor cells. This increases the expression of CD25 on T-lymphocytes, normalizes the production of IL-2, which increases the activity of T-killers against tumor cells. The drug reduces the activity of CD19 molecules, which shield tumor antigens and prevent the attack of cytotoxic T cells. As a result of inhibition of ZAP-70 kinase, CD38 expression is reduced, which increases the bodys antitumor response and mobilizes the cytotoxic potential of CD8 and CD16 T lymphocytes, preventing the development of tumor cell resistance. The restoration of their activity largely predetermines the normalization of other lymphocyte subpopulations, in particular, expressing CD3, CD4, CD8, CD16, CD95, as well as the restoration of the phagocytosis system, production of immunoglobulins of class A, M, G. Such a complex effect ensures the construction of a coherent and effective strategy for immunotherapy of patients with oncopathology.

Published
2018
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4. Медико-географические детерминанты онкопатологии населения

Subjects
oncopathology, irradiation, медицинская география, онкопатология, онкопатологія, облучение, медична географія, опромінення, medical geography
Abstract

The aim: to study the permanent risk factor of oncopathology in order to determine its medical and geographical features and assess their impact on oncopathology of the population of Zaporizhzhia region. Materials and methods. By means of spatial and geographical, as well as analytical and statistical methods, territories were medically and statistically differentiated, with the assessment of the natural environment quality. Epidemiological study of malignant neoplasms was conducted retrospectively for the period of 2004–2015, in accordance with the International Classification of Diseases ICD-10. Determination of environmental impact on oncopathology was performed using the attributive fraction. Results. Geoactive space is characterized by a variety of natural and climatic conditions of lithosphere, hydrosphere and landscapes. The main physical and geographical objects of the Zaporizhzhia region (Ukrainian Crystal Shield, the Dnipro, the Sea of Azov) form six zones, which differ in the diversity of system-forming elements. Specific features of discontinuous disturbances of the lithosphere of the Ukrainian crystal shield are abnormally high electrical conductivity of the earth’s crust, intense electromagnetic fields, high concentration of radon in aquifers, and streams of high-energy fluids. Conclusions. The highest geopathogenic impact is manifested in the fault zone of the Ukrainian crystal shield. The highest values of the attributive fraction of malignant neoplasms were registered in this zone among the whole population (26.8 %), among the adult population (25.4 %) and the able-bodied population (32.7 %). The oncopathological potential of natural conditions was least manifested in the valley of the Dnipro breakthrough and the Azov Upland, where the attributive fraction for almost all indicators did not exceed 8.2 %., Цель работы – анализ постоянно действующего фактора риска онкопатологии для определения медико-географических особенностей и оценки их влияния на онкопатологию населения Запорожской области. Материалы и методы. Пространственно-географическим и аналитико-статистическим методами проведена медико-географическая дифференциация территорий с оценкой качества окружающей природной среды. Эпидемиологическое исследование злокачественных новообразований проведено ретроспективно за 2004–2015 гг. в соответствии с МКБ-10. Влияние окружающей среды на онкопатологию изучали с помощью атрибутивной фракции. Результаты. Геоактивное пространство характеризуется разнообразием природно-климатических условий: литосферы, гид­росферы и ландшафтов. Основные физико-географические объекты Запорожского края (Украинский кристаллический щит, р. Днепр, Азовское море) сформировали шесть зон, отличающихся многогранностью системообразующих элементов. Определены специфические черты разрывных нарушений литосферы Украинского кристаллического щита: аномально высокая электропроводность земной коры, интенсивные электромагнитные поля, высокая концентрация радона в водоносных горизонтах и потоки высокоэнергетических флюидов. Выводы. Самое сильное геопатогенное влияние наблюдали в зоне разлома Украинского кристаллического щита, где зарегистрированы высокие значения атрибутивной фракции злокачественных новообразований среди всего населения (26,8 %), среди взрослого (25,4 %) и трудоспособного (32,7 %) населения. Онкопатологический потенциал природных условий в меньшей степени проявился в долине прорыва Днепра и на Приазовской возвышенности, где атрибутивная фракция почти для всех показателей не превышала 8,2 %., Мета роботи – аналіз фактора ризиків онкопатології, що постійно діють, для визначення медико-географічних особливостей та оцінювання їхнього впливу на онкопатологію населення Запорізької області. Матеріали та методи. Просторово-географічним та аналітико-статистичним методами виконали медико-географічну диференціацію територій з оцінюванням якості навколишнього природного середовища. Епідеміологічне дослідження злоякісних новоутворень здійснили ретроспективно за 2004–2015 рр. за МКХ-10. Вплив довкілля на онкопатологію вивчали за допомогою атрибутивної фракції. Результати. Геоактивний простір характеризується розмаїттям природно-кліматичних умов: літосфери, гідросфери та ландшафтів. Основні фізико-географічні об’єкти Запорізького краю (Український кристалічний щит, р. Дніпро, Азовське море) сформували шість зон, що відрізняються багатогранністю системоформувальних елементів. Визначили специфічні риси розривних порушень літосфери Українського кристалічного щита: аномально висока електропровідність земної кори, інтенсивні електромагнітні поля, висока концентрація радону у водоносних горизонтах і потоки високоенергетичних флюїдів. Висновки. Найвищий геопатогенний вплив спостерігають у зоні розлому Українського кристалічного щита, де зареєстрували найвищі значення атрибутивної фракції злоякісних новоутворень з-поміж усього населення (26,8 %), серед дорослого (25,4 %) та працездатного (32,7 %) населення. Найслабший онкопатологічний потенціал природних умов виявили в долині прориву Дніпра та на Приазовській височині, де атрибутивна фракція майже для всіх показників не перевищувала 8,2 %.

Published
2021

5. Інтелектуалізація процесу діагностування онкопатологій

Subjects
онкопатології, oncopathology, онкопатологии
Abstract

Одним із ефективних способів вирішення проблеми боротьби з онкозахворюваннями є інтелектуалізація процесу діагностування. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/31771 Under extreme intellectual information technologies, based on the ideas and methods of machine learning and pattern recognition, information is considered an extreme method of recognition of morphological imaging of breast tissue obtained at biopsy. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/31771

Published
2013

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