1. ADHESION ILEUS IN CHILDREN IN THE CONNECTIVE TISSUES DYSPLASIA.
- Author
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Kresyun VJ, Меhlnychenko MG, Antonenko PB, Аntonenko KO, and Кvashnina AA
- Subjects
- Adolescent, Alleles, Arylamine N-Acetyltransferase metabolism, Biomarkers metabolism, Child, Female, Gene Expression, Gene Frequency, Humans, Ileus complications, Ileus diagnosis, Ileus pathology, Male, Neoplasm Staging, Neoplasms, Connective Tissue complications, Neoplasms, Connective Tissue diagnosis, Neoplasms, Connective Tissue pathology, Polymorphism, Restriction Fragment Length, Prognosis, Retrospective Studies, Tissue Adhesions complications, Tissue Adhesions diagnosis, Tissue Adhesions pathology, Arylamine N-Acetyltransferase genetics, Genetic Predisposition to Disease, Ileus genetics, Neoplasms, Connective Tissue genetics, Polymorphism, Genetic, Tissue Adhesions genetics
- Abstract
The investigation objective was to estimate the peritoneal adhesions formation risk in children with phenotypic signs of the connective tissues dysplasia (CTD—syndrome). On the first stage the formalized phenotypic clinical signs were estimated in accor' dance to χ2 Pearson criteria (p<0.05). On the second stage a prognostic value of genet' ic polymorphism of N—аrylacetyltransferase—2 (NAT2) gene for determination of risk for the occurrence of postoperative adhesive process in abdominal cavity, using the method of allele—specific amplification of NAT2 аllele with the help of polymerase chain reaction (PCR), was determined. In accordance to results of investigation, obtained in children with CTD—syndrome a genetic polymorphism NAT2 was revealed rather more frequently, responsible for "rapid аcetylation", they constitute the risk group for the adhesion ileus occurrence, in them complex prophylactic measure must be undertak' en, beginning from intraoperative stage.
- Published
- 2016