1. [Protective effect of ischemic preconditioning on hepatic state in its ischemic-reperfusion injury].
- Author
-
Oleshchuk OM
- Subjects
- Animals, Disease Models, Animal, Lipid Peroxidation, Liver enzymology, Liver metabolism, Liver Function Tests, Male, Nitric Oxide metabolism, Rats, Rats, Wistar, Reperfusion Injury blood, Reperfusion Injury metabolism, Treatment Outcome, Ischemic Preconditioning methods, Liver blood supply, Reperfusion Injury prevention & control
- Abstract
There was proved in experimental investigations, conducted on white male rats, that nitric oxide (NO) play the leading role in ischemic preconditioning (IPC) while ischemic-reperfusion affection of the liver. Protective effect of IPC is presented in reduction of the cytolysis processes activity, lipoperoxydation, endotoxicosis severity, improvement in indices of hepatocytic bioenergetic state, mitochondrial transport of electrons and microsomal enzyme system. Increase in the NO end metabolites content, raising of eNOS activity and lowering of iNOS activity proves the NO role in IPC pathogenesis, and it is clear, that its changes in dynamics correlates with reduction of the anti-inflammatory cytokins content.
- Published
- 2013