1. ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.
- Author
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Bebeshko VG, Bruslova KM, Boyarska OY, Lyashenko LO, Tsvyetkova NM, Gonchar LO, Chernysh TO, Trychlib IV, Pismenniy VD, Yaroshenko ZS, and Vasylenko VV
- Subjects
- Adolescent, Arthralgia blood, Arthralgia etiology, Arthralgia pathology, Cell Lineage radiation effects, Child, Child, Preschool, Dental Caries blood, Dental Caries etiology, Dental Caries pathology, Erythroid Cells pathology, Erythroid Cells radiation effects, Fatigue blood, Fatigue etiology, Fatigue pathology, Female, Fractures, Bone blood, Fractures, Bone etiology, Fractures, Bone pathology, Humans, Hydrocortisone urine, Joint Instability blood, Joint Instability etiology, Joint Instability pathology, Male, Puberty blood, Puberty radiation effects, Radiation Dosage, Radiation Exposure adverse effects, Radiation, Ionizing, Radioisotopes, Thyroid Gland pathology, Thyroid Gland radiation effects, Thyrotropin blood, Thyroxine blood, Ukraine epidemiology, Arthralgia epidemiology, Chernobyl Nuclear Accident, Dental Caries epidemiology, Fatigue epidemiology, Fractures, Bone epidemiology, Hematopoiesis radiation effects, Joint Instability epidemiology
- Abstract
Objective: Elucidation of relationship between the levels of thyroid-stimulating hormone (TSH), free serum thyroxine, serum and urine cortisol and parameters of erythroid lineage of hematopoiesis to estimate the thyroid functionin children of prepubertal, pubertal, and postpubertal age permanently residing under a low-dose radiation exposureto determine the premorbid state of thyroid function., Materials and Methods: Children aged 3 to 18 years old (n = 203) living in the most intensively radionuclide-contaminated regions of Kyiv, Zhytomyr and Chornihiv oblasts of Ukraine after the Chornobyl NPP accident wereenrolled. Complaints of ossalgia, arthralgia, fatigue, bone fractures in the history, bone dysembryogenetic stigmata,hypermobility syndrome degree, and types of somatic diseases were taken into account. Peripheral blood countparameters, biochemical indices of blood serum were studied, namely the levels of total protein, cholesterol, creatinine and alkaline phosphatase activity. Levels of the free thyroxine, pituitary TSH, serum and daily urine cortisol, anddoses of radiation exposure were determined., Results: The radiation dose values in children ranged from (0.35 ± 0.09) mSv to (0.54 ± 0.12) mSv. There was nodifference between the parameters of erythroid lineage of hematopoiesis depending on radiation dose. At the levels of serum TSH up to 1.0 μIU/ml no correlation was found with cortisol levels; at TSH levels of 1.0-3.0 μIU/ml thecorrelation coefficient was r = 0.31; at TSH levels higher than 3.0 μIU/ml the correlation coefficient was r = 0.61probably indicating a compensatory role of adrenal cortex in children at risk of thyroid disease development. In children with joint hypermobility grade II there was a higher incidence of dentofacial anomalies (χ2 = 6.9), deformitiesof lower extremities (χ2 = 6.9), and dental caries (χ2 = 4.3) (p < 0.05). There was a direct correlation between theserum TSH level (over 3 μIU/ml) and micrognathia (brachygnathia) (r = 0.62) indicating the impact of thyroid disease on dentofacial development. The TSH at a level of upper limit of the reference range values may contribute toa decreased RBC count in peripheral blood, increased average volume and hemoglobin content in erythrocyte beingassociated with the initial manifestations of thyroid dysfunction., Conclusions: Abnormal endocrine regulation of hematopoiesis affects the connective tissue, stromal microenvironment of bone marrow, and accordingly the erythroid branch of hematopoiesis in children, which may be relevant inthe development and course of oncohematological diseases., (V. G. Bebeshko, K. M. Bruslova, O. Y. Boyarska, L.O. Lyashenko, N. M. Tsvyetkova, L. O. Gonchar, T. O. Chernysh, I. V. Trychlib, V. D. Pismenniy, Z. S. Yaroshenko, V. V. Vasylenko.)
- Published
- 2020
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