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There were examined 142 patients with recurrent headache (cephalgia) and arterial hypertension, a mean – 49.26±1.33 years, of whom 69 men, 73 women who used intermittent fasting (patients spent 24 hours without food, 1 time per week, four repetitions). The control group consisted of 32 people of comparable age without hypertension (n=32; mean age 51.0±1.99 years). The purpose of the study was to increase the effectiveness of diagnostic and therapeutic methods in patients with hypertension and headache by establishing the meaning and peculiarities of the influence of intermittent fasting on headaches, neck carotid and intracranial circulation. There were 51 (35.9%±4.03) patients aged 25-44 years’; 45-59 years – 42 (29.58%±3.83) patients; 60-75 years – 49 (34.51%±3.99) patients. It was found that the structural pathology of the main arteries of the head consisted mainly in the thickening of the intima-media from 0,8 to 1,4 mm in 62.7% at the age of 25-44 years; in 71,4% at the age of 45-59; in 51% at the age of 60-75 years. Local thickenings in the bifurcation zone from 1.5 mm without hemodynamically significant stenosis were found in 9.8% at the age of 24-44 years, in 28.6% at the age of 45- 59 years and in 49% at the age of 60-75 years. Statistical differences in linear circulatory velocity between the control group and the group of patients were significant already at the age of 25-44 years, for peak systolic velocity in the internal carotid artery (78.03±4.67 vs. 61.0±2.54 in control, p<0.05). At the age of 45-59 years, linear circulatory velocity affected all carotid and vertebral arteries, as in the group aged 60-75. The effect of intermittent fasting on aged hemodynamics consists mainly in changes of velocity of flow in arteries with better results in younger patients. Changes in the elastic-tonic characteristics of the main arteries of the head according to the index of resistance (index was 0.72±0.01 for common carotid artery and 0.63±0.01 after intermittent fasting in patients at the age of 25-44 years; 0.78±0.01 before and 0.67±0.01 after at the age of 60-75 years were revealed). The use of the intermittent fasting method caused mainly an increase in diastolic flow rates in the main arteries (with age dependences) and a decrease in systolic velocity in the age group 25-44 years. The pathophysiological interpretation of such changes is in the reducing the resistance, values of the main arteries of the head. [ABSTRACT FROM AUTHOR]

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Goal. Investigation of the main kinematic parameters of a shredding machine with two moving tanks connected by a translational kinematic pair and performing complex spatial motion to be able to further predict the technological result at the design stage of such equipment and the corresponding technological operations of machining parts. Method. Using the SolidWorks-2016 Motion computer-aided design system, 3D modeling was carried out, followed by kinematic analysis, of a machine for processing parts with two movable capacities, which are interconnected by a translational kinematic pair and perform complex spatial motion. The essence of kinematic analysis was to determine the linear velocities and accelerations of points that coincide with the ends of the working tanks of the machine. Results. Based on 3D modeling and kinematic analysis in the SolsdWorks-2016 Motion computeraided design system, some kinematic parameters of the machine are determined, in particular, the law of the change in the angular velocity of the driven shaft of the machine is obtained in the form of graphical dependencies, the change in the translational speed and translational acceleration of four points, which are conventionally located in the center, is studied the ends of each of the working capacities. Scientific novelty. The relationship between some kinematic parameters of the developed machine design with two moving capacities that perform complex spatial motion is established. Practical importance. It was found that the kinematic parameters of the two tanks of the machine differ from each other, as a result of which, during the execution of the corresponding technological operations, the intensity of movement of the working array in the two capacities will differ from each other. In addition, the ends of each of the working capacities move with almost the same kinematic parameters, which will facilitate the movement of the working array between the opposite ends of both tanks in opposite directions with the same intensity. The results obtained make it possible to determine the most rational functional purpose of the machine under study. [ABSTRACT FROM AUTHOR]

Different views on the definition of «stability of wheeled vehicles» are considered and the author’s own definition is offered. A version of the structure of stability properties as a complex op-erational property is offered.