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Bladder cancer (BC) is a 9th most common cancer in the world that make from 3% of global neoplasms. Bladder cancer is prevalent in the developed countries. Cancer of the bladder is four times more common in men than women. External risk factors and internal triggers contribute to the development of bladder cancer. Thus, comprehensive analysis of these risk factors is a earnest to timely prevention of indicated oncologic pathology. The objective: to do a current systematic review of epidemiology of bladder cancer and modern important risk factors, which appropriate to the given pathology. Evidence acquisition. We carried out a systemic review of epidemiology of bladder cancer embracing PubMed and Embase including March 2023. All studies reporting gender, smoking, E-cigarette use, opium consumption, occupational carcinogene expose, dietary factors, race, gene-environment interaction, socioeconomic status. Microbiome factors, urolithiasis, benign prostate hyperplasiapelvic radiotherapy were excluded. Evidence synthesis. A total of 516 papers, that studied epidemiology of bladder cancer, were involved. According to GLOBOCAN, there were 573 000 new bladder cancer cases and 213 000 deaths worldwide in 2020. Smoking and occupational exposures (aromatic amines and polycyclic aromatic hydrocarbons) are the most important risk factors. Moreover, the additional risk factors include some dietary agents, gene specificities, diesel exhaust emissions and etc.. Conclusions. Smoking tobacco and specific occupational exposures are the most important risk factors. Prevention strategies, including smoke cessation, responsible workplace safety, diet, schistosomias prevention are useful for reduction of the incidence BC. But high-quality studies are required to confirm initial results that will support timely prevention of BC. [ABSTRACT FROM AUTHOR]

The Ukrainian system of medical and social expertise needs to revise its conceptual and methodological foundations in accordance with the realities of the current development of social sciences in the world and demand of the state regarding the modern understanding of disability. The purpose of the study was to analyze international experience and legislation on policy towards persons with disabilities and systematic approaches to the criteria of violation of functioning and the possibilities of determining the status of "person with disabilities" using the basic principles of the International Classification of Functioning (ICF), Impairment and Health to create optimal approaches to determining the criteria for disability in Ukraine. The study was based on the analysis of available scientific literature and legislative documents of developed countries on the understanding of the concept of "person with a disability". The scientometric databases used were Scopus, Web of Science, Google Scholar, and MedLine. Data from the official websites of the Political Department of the European Parliament, WHO, the United Nations, UNICEF, the World Bank. According to the results of the study, it is determined that a single state body is responsible for determining the status of a person with a disability in sustainable development countries using a multidisciplinary approach. The author identifies 3 main components that most developed countries assess when determining disability: economic, medical and social. At the same time, the main criterion is decreased performance. It has been established that since 2022, Spain has completely switched to the criteria of the International Classification of Functioning in determining the signs of disability, basing the severity of a person's condition as a degree of disability on a percentage decrease in the person's functioning. Some European countries use selective categories of the ICF. [ABSTRACT FROM AUTHOR]