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Antipsychotic-induced noticeable weight gain and metabolic syndrome cause serious health problems in psychiatric patients with the foremost of diabetes. The nature of medication-induced weight gain is not the same for everyone; besides varying with the medication and person, most frequently it is observed in people using atypical antipsychotics. Mostly Foremost genetic, but also other studies researching to predict what rate of weight gain in which patients have been going on. With the aim of guiding future genetic studies exploring the genetics of weight gain the previous studies conducted on this topic were reviewed in this study.

Alcohol addiction is a chronic, relapsing disorder with a huge societal impact. Understanding the genetic basis of alcohol addiction is crucial to characterize individuals' risk and to develop efficacious prevention and treatment strategies. Recent studies have also begun to focus on the molecular mechanisms and epigenetics of alcohol addiction. Changes in gene expression in brain reward regions are thought to contribute to the pathogenesis and persistence of drug addiction. Data from classical genetic studies to new epigenetic studies could show us new dimensions of alcohol addiction. Data from genetic studies also guide pharmacotherapeutic agent choice for optimum treatment of alcohol addiction. In this review, we examined the Pubmed database, using alcoholism, genetics, epigenetics and polymorphism key words and than discussed results of studies. (Anatolian Journal of Psychiatry 2009; 10:239-245)

Previous studies have demonstrated that dopamine (DA) receptor agonists enhanced locomotor activity. The present study was designed to determine the relative contribution of D1 and D2 (DA) receptor subtypes in motor coordination. Apomorphine, a nonselective dopamine receptor agonist. decreased motor coordination at the doses of 0.125 and 0.25 mg/kg, but increased the motor coordination at 0.5 and 1 mg/kg. The D2 dopamine receptor antagonists, sulpiride (50 mg/kg) and spiperone (40 ?g/kg). decreased motor coordination when administrered either alone or combination with apomorphine (0.5 mg/kg). Selective D1 receptor agonist SKF 81297 (10 mg/kg) enhanced motor coordination. The effect of SKF 81297 was antagonized by fluphenazine (0.125 mg/kg). The D2 receptor agonist bromocriptine (5. 10, 20.30 mg/kg) significantly increased motor coordination. The effect of bromocriptine (10 mg/kg) was inhibited when administered either sulpirid (50 mg/kg) or ?-methyl p-tyrosine prior to bromocriptine. These data demonstrated that both D1 and D2 receptors may involved in motor coordination.