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An experiment was carried out at the ICAR-KVK Research farm, HansRoever Campus, Perambalur, Tamil Nadu, India during the Kharif season (July to October), 2020 to study the effect of agronomic biofortification through integrated nutrient management on hybrid maize (biofortified and non-biofortified). The experiment was laid out in Split Plot Design having 36 treatment combinations of hybrids and nutrients and replicated thrice. The treatment sources consisted of two main plots of maize hybrids (M1: Non-biofortified and M2: biofortified), and six sub-plots of nutrients (S1: 100 % Recommended Dose of Fertilizer RDF through Nitrogen, Phosphorus, Potassium, S2: 100 % RDF through Farm Yard Manure, S3: 50% RDF through NPK + 50% RDF through FYM, S4: S1+ Iron and Zinc as foliar application @0.5% conc, S5: S2 + Iron and Zinc as foliar application @0.5% conc, S6: S3 + Iron and Zinc as foliar application @0.5% conc.). The recommended dose of fertilizer was NPK 150:75:75 kg ha-1. Application of 50% RDF through NPK + 50% RDF through FYM with Fe and Zn as foliar application @0.5% conc (S6) at 45 (active vegetative stage) and 90 (grain filling stage) days after sowing, significantly increased all the growth and yield attributes, grain and stover yield, quality attributes and nutrient uptake by maize. Among the nutrient levels, higher grain yield (8.2 t ha-1) and stover yield (10.16 t ha-1), quality attributes, and nutrient uptake were recorded with the application of 50% RDF through NPK + 50% RDF through FYM with Fe and Zn as foliar application @0.5% conc (S6). Similarly, significant net return (INR 78,767) and benefit cost ratio (3.07) were noted with the application of 100% RDF through NPK (S1) followed by 50% RDF through NPK + 50% RDF through FYM with Fe and Zn as foliar application @0.5% conc (S6). Hence, integrated nutrient management with agronomic biofortification @0.5% conc., at 45th and 90th DAS should be adopted to obtain maximum grain yield, net profit, and nutrient uptake by Kharif maize.