Search

Objective: Sarcomatoid urothelial carcinoma has an aggressive nature; a worse prognosis, a more advanced stage and a greater risk of metastasis than other types of urothelial cancers. In this study, the clinical and histopathological results of 10 patients with sarcomatoid urothelial carcinoma of the bladder will be presented and the current literature will be reviewed. Material and Methods: The study included 10 patients histopathologically diagnosed as sarcomatoid carcinoma between November 2012 and December 2018. Demographic characteristics and pathology results were evaluated retrospectively. Patients were evaluated with detailed history, physical examination, routine biochemical and hematological examination, urinary ultrasonography, abdominopelvic tomography, chest radiography and cystoscopy before surgery. Results: The mean age and mean followup period of the patients were 70.2 (51-81) years and 9.2 (2-18) months respectively. The mean symptom of the patients was macroscopic hematuria. Six (60%) patients underwent radical cystectomy. One patient received neoadjuvant chemotherapy. One (16.6%) patient had a stage of pT2b tumor, three (50%) patients had a stage of pT3 tumor and two (33.3%) patients had a stage of pT4 tumor after radical cystectomy. Three (50%) patients were found to have N1 disease and three (50%) patients had coexisting carcinoma in situ (CIS). Metastasis for lymph node involvement was present in three (50%) of the patients. Six (60%) patients have died due to disease, four (40%) patients are still continued to follow up. Conclusion: Sarcomatoid carcinoma of the bladder is usually an aggressive tumor and patients are referred with advanced stages. Despite radical surgery, these patients should be followed up closely as early recurrence and progression can be seen.