Search

Introduction: Adverse drug reactions is an important healthcare issue, it causes excess morbidity and mortality. The aim of this study was to determine the adverse drug reactions in patients who admitted to the outpatient clinic of respiratory diseases and to improve some clinical strategies if they are preventable., Patients and Methods: This study is a prospective observational study which was performed to determine adverse drug reaction in patients who admitted to the outpatient clinic of respiratory diseases., Results: During the 15 months of study period a total of 114 adverse reactions were reported in 92 out of 18.130 patients. Most of the adverse reactions were related with gastrointestinal system, central nervous system and cardiovascular system. The most of the adverse events were associated with fixed inhaled formoterol-budesonide combination and inhaled tiotropium. The most frequently reported reactions were hoarseness, xerostomia, headache and dizziness. Poliuri and cough were less frequently reported reactions., Conclusion: Most of the adverse reactions were of limited intensity but some of these side effects might effect patients compliance. Serious adverse events were not detected.

Objectives: We compared the extent of healing and hearing improvement following tympanoplasties performed with the use of cartilage-perichondrium composite grafts and temporalis muscle fascia grafts., Patients and Methods: Fifty consecutive patients (22 males, 28 females; mean age 30+/-14 years; range 11 to 63 years) with chronic otitis media were divided into two groups to receive cartilage-perichondrium composite grafts or temporal muscle fascial grafts. All the patients were evaluated by pure-tone audiometry and otomicroscopic examination in the 1st, 3rd, 6th, and 12th months., Results: At the end of the first year, graft survival was 92% in the cartilage group, and 85% in the fascia group. Hearing levels improved at the end of the first year; however, the two groups did not differ significantly in terms of hearing improvement and graft survival. Hearing gains were greater in central and subtotal perforations. In comparison with a steady increase in the cartilage group, hearing levels remained unchanged after the sixth month in the fascia group., Conclusion: Cartilage-perichondrium composite grafts may be easily and safely used in type I tympanoplasties, with successful results including hearing improvement.