Search

Tazarotene is a synthetic retinoid that regulates gene transcription by binding to high affinity retinoid acid receptor beta and gamma Tazarotene has cream, gel and foam forms. Tazarotene is a well tolerated drug with low systemic absorption when administered topically. Tazarotene is mainly used in the treatment of acne vulgaris and psoriasis. However, tazarotene is recommended more frequently in the treatment of skin diseases. Within this study, skin disease treated with tazarotene have been reviewed in the light of recent literature.

Tamer, F., The Effects of Dietary Fatty Acids and Fructose on Some Inflammatory Mediators and Fatty Acid Biosynthesis in Mice, Hacettepe University Institute of Health Sciences Nutrition and Dietetics Program, Doctor of Philosophy Thesis, Ankara, 2017. Currently, consumption of high quantities of fructose and saturated fatty acids via processed food is recognized as a central factor in the development of chronic disease. The aim of this study was to investigate the effects of dietary high saturated fatty acid or fructose on lipogenesis, insulin resistance and inflammation. The study was performed on the C57Bl/6 type male mice (n=40, 8 weeks old) with ad libitum access to chow diet and three different type of diets enriched with two different fatty acids (refined olive oil, coconut oil) and carbohydrate (fructose) types for 15-weeks. At the end of the dietary period, the animals were sacrificed; then organ and tissues isolated immediately. As a result, it was found that mean feed intake of fructose fed group was higher (p

Psoriazis etyolojisi net olmayan, immün aracılı mekanizmalarla gelişen,kronik inflamatuar bir deri hastalığıdır. Kronik inflamasyonun, vasküler vemetabolik bozuklukların gelişmesine neden olarak psoriazise eşlik edenkomorbiditelerin patogenezinde rol oynadığı düşünülmektedir. Psoriazise eşlikeden hastalıklar arasında psoriatik artrit, inflamatuar barsak hastalıkları,metabolik sendrom ve kardiyovasküler hastalıklar, maligniteler, akciğerhastalıkları ve depresyon yer almaktadır. Özellikle metabolik sendromkomponentlerinden olan obeziteyle psoriazis arasında güçlü bir ilişkidenbahsedilmekte, psoriazis, beden kitle indeksi ve psoriazis tedavisinin karmaşıkilişkisi üzerinde durulmaktadır. İnflamasyonu ve immün yanıtı baskılamayıhedefleyen ilaçların, komorbidite gelişme riskini azaltmada ve tedavide etkili olupolmadığı net değildir. Son dönemlerde psoriazis tedavisinde, psoriazispatogenezinden sorumlu immün yanıtın önlenmesini hedefleyen biyolojik ajanlarkullanılmaya başlanmıştır. Yapılan çalışmalarda psoriazisin sistemik tedavisiyleilişkili metabolik değişikliklerden ve anti-TNF-? tedavisiyle meydana gelen kilodeğişikliklerinden bahsedilmektedir Psoriasis is a chronic inflammatory immun mediated skin disorder withunknown etiology. The chronic inflammation in psoriasis have role in thedevelopment of metabolic and vascular disorders related with associatingcomorbidities. The comorbidities of psoriasis are listed as psoriatic arthritis,inflammatory bowel disease, metabolic syndrome and cardiovascular diseases,malignancy, pulmonary disease and depression. Recent studies have suggested astrong association exists between metabolic syndrome, obesity and complexity ofthe association between psoriasis, body mass index and psoriasis tratment. It isunclear whether or not drugs targeting inflammation and immunsuppression effectthe risk or treatment of comorbidities. Biological agents that selectively block theimmunologic steps implicated in the pathogenesis of psoriasis are a relatively newclass of treament for psoriasis. Recently studies indicate the metabolicabnormalities associated with initiation of systemic treatment for psoriasis and theeffects of anti-TNF therapy on the weight of patients. 173

Bu çalışma Hacettepe Üniversitesi, Ankara Üniversitesi ve Gazi Üniversitesi'nde öğrenim görmekte olan, 19-30 yaş arası kadın bireylerde, beslenme alışkanlıkları, diyetin karbonhidrat kaynakları, yeme davranışları ve beden kütle indeksi arasındaki ilişkinin incelenmesi amacıyla gerçekleştirilmiştir. Bireylerin genel ve antropometrik özelliklerini, 3 günlük besin tüketim ve fiziksel aktivite kaydını ve yeme tutum davranışlarını sorgulamak üzere hazırlanan soru kağıtları araştırmacı tarafından gönüllü katılımcılara uygulanmıştır. Çalışmanın sonucunda bireylerin beden kütle indeksi değerleri; toplam diyet posası ile kuvvetli negatif ilişkili, diyetin glisemik indeks değerleri ile ise kuvvetli pozitif ilişki bulunmuştur (p0.05). Yine beden kütle indeksi gruplarına göre, yeme tutum testi sonuçları farklı bulunmamıştır (p>0.05). This study was conducted on 300 female subjects aged between 19-30 years old who are the students of Hacettepe University, Ankara University and Gazi University. The aim of this study is to investigate the relationship between dietary carbohydrate sources, eating behaviors and body mass index measurements in the university students. The questionnaire designed to assess general characteristics, anthropometric measurements, 3 day dietary record, physical activity records and Eating Attitudes Ttest which was performed by the researcher and was administered to the volunteer participants. At the end of the study, there was a strong negative correlation between body mass index and total dietary fibre. There was a strong positive correlation between body mass index and glycemic index values (p 0.05). Also, there was no significant difference between the participants Eating Attitudes Test results according to the BMI groups (p> 0.05). 217