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Aim: According to the information obtained from the World Health Organization database, the incidence of hepatocellular carcinoma (HCC) in Turkey increased by 17.78% between the years of 2018 and 2020. In this study, we investigated the prognostic value of albumin-bilirubin (ALBI) score and lymphocyte-associated inflammation markers on overall survival (OS) and progression-free survival (PFS) in advanced hepatocellular carcinoma. Materials and Methods: Data of 141 patients with advanced HCC were included in this study. ALBI score and lymphocyte-associated inflammatory marker were calculated. As a result, the prognostic significance of these tests for survival were evaluated. Results: The median age was 65 years (min: 26-max: 88). There were 58 (41.1%) hepatitis B virus (HBV) positive, 20 (14.2%) hepatitis C (HCV) positive and 63 (44.7%) patients with no history of hepatitis. Cut-off values of ALBI score and lymphocyte-associated inflammation markers were found by receiver operating characteristic analysis. ALBI (p

Purpose: This study aimed to examine the prognostic value of perioperative NLR level in terms of mortality in the first postoperative year in elderly patients undergoing hip fracture surgery. Materials and Methods: The study included 236 patients (68.6% female and 31.4% male) who met the specified criteria and had undergone hip fracture surgery. Complete blood counts were recorded at admission and on the fifth postoperative day. Neutrophil-to-lymphocyte ratios (NLR) at admission (NLR-D0) and on the fifth postoperative day (NLR-D5) were identified as the primary variables. Results: The mean age of the participants was 80.1±7.9 years (min: 65 years to max: 99 years). The mean NLR-D0 and mean NLR-D5 values of surviving patients were 6.54 and 4.55, respectively. The mean NLR-D0 and mean NLR-D5 values of patients who died were 6.99 and 8.90, respectively. A significant difference was found in the NLR variability of the patients who survived and those who died. The examination of the effects of NLR-D0 and NLR-D5 parameters on mortality revealed no significant difference in NLR-D0 values between the patients who lived and those who died (p>0.05), but the NLR-D5 value was significantly higher in the patients who died. The mortality rate at the end of the first postoperative year was 35.2%. Conclusion: A high NLR value (NLR-D5>7.85) on the fifth postoperative day in elderly patients undergoing hip fracture surgery may be a predictor of 1-year mortality after hip fracture surgery.

Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The systemic immune inflammation index has been considered a novel prognostic biomarker in several malignant tumors. The aim of the current study was to determine the association between the systemic immune inflammation index and prognosis of patients with Diffuse Large B Cell Lymphoma. Material and Method: The study included 101 patients diagnosed diffuse large B cell lymphoma. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off value of the systemic immune inflammation index for predicting survival. Results: The results of ROC curve analysis showed a cut-off value for the systemic immune inflammation index of 500. No statistically significant difference was determined between the groups with systemic immune inflammation index ≤ 500 and >500 groups in respect of overall-survival and progression-free survival. The mortality risk was determined to be significantly higher in patients with systemic immune inflammation index ≤ 500 (p:0.017). There was no significant relationship between the systemic immune inflammation index values and lactat dehydrogenase, age, R-IPI risk groups,ECOG performance status, and disease stage. Conclusion: The results of this study demonstrated that there is no association between the systemic immune inflammation index and survival in patients with diffuse large B cell lymphoma. Larger prospective studies are needed to investigate the association between the systemic immune inflammation index and Diffuse Large B Cell Lymphoma.

Objective: This study aimed to investigate the survival outcomes, recurrence patterns, and treatment-related toxicities of endometrial cancer (EC) patients who underwent adjuvant radiotherapy. Materials and Methods: Between January 2012 and December 2021, one hundred fourteen patients who underwent adjuvant radiotherapy with the diagnosis of endometrial cancer were retrospectively analyzed. Cases were evaluated for overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), cancer-specific survival (CSS), and distant metastasis-free survival (DMFS). Results: Median follow-up was 63 months (8 -135). At 5 years OS, DFS, LRFS, CSS, and DMFS were 85.5%, 90.5%, 98.9%, 94.1%, and 90.5%, respectively. Univariate analysis of lymphovascular space invasion (LVSI) is statistically significant for DFS, DMFS, and CSS, respectively (p=0.019, p=0.019, p=0.021) and histology, tumor grade, stage were statistically significant for LRFS, respectively (p=0.031, p=0.010, p=0.049). Grade 1 and 2 acute gastrointestinal toxicity were observed in 40 patients (35.1%). Grade 1 acute genitourinary toxicity was observed in 35 patients (30.7%). Grade 3 late genitourinary and gastrointestinal toxicity was observed in 0.9% and 1.8%, respectively. Conclusion: Histology, grade, LVSI, and stage didn’t significantly affect overall survival, but LVSI and stage were the most influential prognostic factors on relapse patterns. Adjuvant radiotherapy is safe and well tolerated by patients with endometrial cancer with acceptable toxicity.

Purpose: The De Ritis ratio (Aspartate transaminase/alanine transaminase) is a critical prognostic factor for some kinds of malignant tumors. Nevertheless, the De Ritis ratio’s prognostic value in preoperative colon cancer staging is unclear. The purpose of this research was to determine the De Ritis ratio and its prognostic significance for colon cancer. Materials and Methods: The clinicopathological data of 271 individuals with malign colon cancer were analyzed retrospectively at a single center from January 2010 to January 2018. The relationship between the De Ritis coefficient and clinicopathological findings in patients was evaluated before treatment. To compare the groups, the Mann-Whitney U test and the Kruskal Wallis test were performed. Results: The results indicated that there were no statistically significant differences between the groups in terms of pre-treatment De Ritis ratio assessment as a staging, localization, tumor diameter, lymph node metastasis, age, and overall survival. However, differences in T staging between groups of male participants were shown to be statistically significant. Conclusions: The De Ritis ratio evaluation before treatment was not found as an independent variable prognostic factor for the diagnosis and staging of colon cancer. However, future studies may demonstrate the significance of the De Ritis ratio with more participants.

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Copyright of Çankırı Karatekin University Journal of the Faculty of Economics & Administrative Sciences is the property of Cankiri Karatekin University, Faculty of Economics & Administrative Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract Objective: The aim of this study is to report the survival and treatment results of patients with cervical esophageal cancer treated with definitive chemoradiotherapy, whose incidence is very low in the population and there is not enough information about treatment and toxicity results in the literature. Material and Method: Between 2013 and 2022, 10 patients (six males and four females) with cervical esophageal cancer treated with definitive chemoradiotherapy were included. Among these patients, seven had stage II disease, one stage III, and 2 stage IVA. All patients received radiotherapy at a median dose of 50.4 Gy and concurrent weekly chemotherapy. Results: The median follow-up period was 18 months. The two-year and 5-year overall survival rates were 42.2% and 21.1%, respectively. The two-year and 5-year disease-free survival rates were 45.7% and 22.9%, respectively. Disease progression was noted in 3 out of 10 patients (30%). Three patients were still alive during analyze. Percutaneous enteral gastrostomy was performed in 3 of 10 patients. These requirement occured in 1 due to local progression, and in the remaining 2 patients due to the side effect of RT. Conclusions: Overall survival rates were low, as similar findings appear in the literature. It was remarkable that the need for a percutaneous enteral gastrostomy was not observed in the IMRT group. All patients with complete remission were in stage 2.

Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim:Medullary thyroid carcinoma (MTC) originating from parafollicular C cells is a sporadic endocrine tumor. A unique aspect of the disease is that it is 25% familial and component of multiple endocrine neoplasia 2 syndromes. Surgical resection has curative potential in the early stages. Systemic treatment options are available for unresectable or advanced disease. Due to the rare and limited treatment options for the disease, we found it appropriate to share the results of our patients in our center.Materials and Methods:We enrolled 47 progressive MTC patients in the study between June 2000 and June 2019. Demographic and clinical characteristics of the patients, as well as treatment outcomes, were evaluated. Statistical analyses were performed to identify risk factors associated with survival.Results:The median age was 46 years, and the male to female ratio was 32/15. All patients’ Eastern Cooperative Oncology Group - Performance Status (ECOG-PS) was 0 (66.7%) or 1 (33.3%). While 73% of the patients had lymph node metastasis, 22% had distant organ metastasis at initial diagnosis. Local recurrence was found to be the most common progression type (80.9%). The most frequent distant metastatic sites at progression were the bone (68.1%) and lung (23.4%). From the start of systemic therapy, the median progression-free survival and median overall survival (OS) were 51.7 months and 55.6 months, respectively. Vandetanib was associated with a better OS than systemic treatments (84.7 months vs. 37.1 months, respectively; p=0.047). Patients whose ECOG-PS was 0 had better OS than those with ECOG-PS 1 (77.2 months vs. 34.4 months, respectively; p=0.002). Also, ECOG-PS was determined as an independent prognostic factor [hazard ratio (HR): 14.7; 95% confidence interval (CI): 1.7-124.7; p=0.013].Conclusion:Although the patients with progressive MTC have relatively long survival, systemic treatment options are limited. The ECOG-PS needs to be evaluated in absolute terms in patient management. In addition to tyrosine kinase inhibitors, chemotherapy and 177Lu-octreotate may be effective in selected patients.

Aim:The scoring system of the hematopoietic cell transplantation comorbidity index (HCT-CI) was used in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT), and it could predict progress-free survival and overall survival. Our study aims to determine the ideal cut-off value for the HCT-CI score, which can be effective in showing overall survival in patients with MM undergoing ASCT.Methods:The files of all MM patients with ASCT between January 2015 and December 2020 were retrospectively scanned. The X-tile model was used to determine the cut-off values of the HCT-CI score. Survival probabilities were calculated using the Kaplan-Meier estimator. The Cox proportional hazard regression model was used for univariate and multivariate analyses.Results:Patients were divided into two categories according to HCT-CI. Score ≤6 was defined as low-risk (n=93, 81.6%), and score >6 was defined as high-risk (n=21, 18.4%). The low-risk group had one-year and two-year OS rates of 96.7% and 86.9%, respectively, while the high-risk group had rates of 69.9% and 40.3% (p6 were found to be significant, with an HR of 3,718 and 5,543, respectively.Conclusion:Hematopoietic stem cell transplantation - comorbidity index score >6 can aid physicians in deciding whether to perform ASCT in MM patients and predict the overall survival of those patients.

Copyright of Anatolian Clinic Journal of Medical Sciences is the property of Hayat Saglik ve Sosyal Hizmetler Vakfi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Academic Research in Nursing (JAREN) is the property of Hemsirelikte Egitim ve Arastirma Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The primary aim of the study was to analyze the changes in time in HIV care and management and virologic success rates. The secondary aims were to analyze the epidemiological features, clinical and laboratory findings, and factors affecting survival. Methods: HIV-infected individuals aged ≥ 18 years presenting to our clinic between January 1996 and December 2015 were included. Data were collected retrospectively from medical records, and two decades (1996-2005 and 2006-2015) were analyzed. Results: Overall, 80% were male; the median age (min; max) was 36.43 (17; 77) years. Patients with stage 3 disease were significantly higher in the first decade compared to the second decade (p=0.00). The median (min; max) CD4+ T lymphocyte count at baseline was 160 (3; 650) and 355 (0; 1800) cells/mm3 in the first and second decades, respectively (p=0.00). The treatment initiation rate was 94.2%; virologic suppression rates at six months of treatment and throughout the total follow-up time were 70.1% and 78.1%, respectively. The difference between the two decades in virologic suppression was significant (p=0.004). AIDS-defining disease developed in 12.9% (52.6% in the first and 11% in the second decade) (p=0.01). The adverse event rate was 60.8%; hyperlipidemia was the most common (60.2%). The death rate was 6.5% and lymphoma (14.3%) and tuberculosis (10.9%) were the most common causes of death. The estimated survival time was 272 months (95% confidence interval 225-320). The inability to achieve virologic suppression, an AIDS-defining disease, and a baseline CD4+ T lymphocyte count <200 cells/mm³ was inversely correlated with survival time. Conclusion: Significant improvements in HIV care and management were recorded in time in our cohort in line with the improvements in global HIV care. Treatment and viral suppression rates were above the Joint United Nations Programme on HIV/AIDS -- UNAIDS 90-90-90 target in the second decade. This may be attributed to the recent developments in antiretroviral treatment and the competence of the HIV team in the Aegean University Medical Faculty Infectious Diseases and Clinical Microbiology Department. [ABSTRACT FROM AUTHOR]

Objective: Testicular cancer (TCa) is still the most frequent solid organ cancer in men aged 15-35 years. Mean platelet volume (MPV) alteration is used as an indicator in some cancer. We evaluated MPV levels and their significance as one of the prognostic factors in TCa. Methods: Between January 2006 and October 2019, all TCa data of our clinic were researched. Total of 133 patients diagnosed with TCa enrolled. Age, tumor size, blood tests, clinicopathological data including lymphovascular invasion, pathological stage, invasion of epididymis, spermatic cord, surgical margin, retroperitoneal lymph node involvement in radiological examinations, and metastasis were recorded. The potential prognostic value of MPV was evaluated using receiver operating characteristics (ROC) curves. Prognostic factors were analyzed. Significant p was p

Purpose: Colorectal cancers, which are one of the most common types of cancer, take the first ranks in terms of mortality. Various factors, such as smoking, are considered risk factors in CRC. In this study, germline mutations in 18 genes were examined by Next Generation Sequencing analysis and the role played by smoking and genetic effects in colon cancers were compared. Materials and Methods: In this retrospective study, paraffin blocks of 50 patients with colon cancer that were followed up in between 2010 and 2018 were included. The bioinformatics program SOPHiA DDM® was used for next-generation sequencing. The data of the study were evaluated by the IBM SPSS Statistics Standard Concurrent User V 25 (IBM Corp, Armonk, New York, USA) statistics program. Results: In the study, it was concluded that the presence of APC and MUTYH genetic mutations was 3.083 times more common in patients with distant organ metastasis compared to patients without metastasis and these patients exhibited 6.364 times more TP53 genetic mutations. Also, a relationship was found between APC, MUTYH, and MSH2 and tumor stage. There was no statistically significant relationship between smoking status and Colon Ca patients with and without distant organ metastasis. Conclusion: APC and MUTYH were found to have a bad effect on overall survival. It was determined that there was a significant relationship between the patients' grade, stage, and overall survival status. A significant relationship was found between the expected survey of age and grade in patients with distant organ metastasis.

Purpose: Some patients with cancer use herbal therapy as an adjunct while receiving conventional cancer treatments. Beta-glucans have direct cytotoxic effects on cancer cells as well as stimulatory effects on the immune system. In this study, a nutritional supplement containing 1,3-1,6 beta-glucan obtained from baker's yeast (Saccharomyces cerevisiae) was used by patients diagnosed with sarcoma, and this study aimed to retrospectively evaluate the effect of beta-glucan use on the incidence of neutropenic fever (NF) and survival rates. Materials and Methods: Among the patients diagnosed with sarcoma between 2014 and 2017, 27 patients who used beta-glucan were included in the beta-glucan group, and 31 patients who did not use beta-glucan were included in the control group. The clinical records of patients were retrospectively analyzed. Results: The number of patients who had NF and the mean length of hospital stay due to NF were higher in the beta-glucan group than those in the control group, but the results were not statistically significant. The overall survival rates at 5 years were 83.3% and 52.9% and event-free survival rates at 5 years were 48.1% and 71% in the beta-glucan and control groups, respectively. Conclusion: The effect of prophylactic beta-glucan use on the incidence of NF and survival rates in pediatric patients with sarcoma should be evaluated more reliably in further prospective studies on a large patient group.

Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: Lymph node ratio (LNR) represents the ratio of positive lymph nodes to total excised lymph nodes. We analyzed the correlation between LNR and outcomes in patients who have undergone surgery for SCC of the head and neck. Materials and Methods: Thirty-three patients with head and neck squamous cell carcinoma (HNSCC) who underwent surgical resection and neck dissection were included. Kaplan-Meier analysis and log-rank test were used to compare differences in disease-free survival (DFS) and overall survival (OS). Results: In total, 28 males and 5 females with a median of age 57 years were identified, with a median recorded LNR of 0.1. The median DFS was 10.4 months, and the median OS was 32.5 months. When DFS and OS were compared by Kaplan-Meier survival analysis, we found that patients with the median LNR≥0.1 had significantly worse DFS (p:0.029) and OS (p:0.036) than patients with ratios below these threshold values. Considering other known predictors of recurrence and survival, we found that LNR was significantly associated with DFS (p=0.036, HR 0.38, 95% CI 0.15-0.93) and OS (p=0.042, HR 0.40, 95% CI 0.17-0.96). Conclusion: Our study showed that high LNR was an independent predictor of outcome in patients with HNSCC. In HNSCC, LNR can be used as an additional parameter to predict recurrence and survival.

Purpose: Small cell lung cancer (SCLC) is a type of lung cancer that is sensitive to chemotherapy but has a poor prognosis. In this study, we aimed to investigate the prognostic significance of the lymphocyte / monocyte ratio and clinical and laboratory parameters. Materials and Methods: In this study, medical records of 146 patients who were diagnosed with SCLC between January 2014 and December 2019 and were in the extensive stage were analyzed retrospectively. The lymphocyte / monocyte ratio (LMO) was calculated from the blood tests taken before chemotherapy. Results: Median overall survival (OS) was 8.78 (range 1.07-54.80) months, progression-free survival (PFS) was 5.6 (1.07 - 44.03) months in the patients enrolled in the study. In the cohort analysis of all patients, the median PFS was 4.5 months, OS 7.5 months in the low group with LMO and 6.5 months, OS 10.1 months in the high group with LMO. When examined by univariate analysis, patients with high LMO also had longer OS than patients with low (HR 0.591 95% CI 0.42-0.83 p=0.003). When analyzed by multivariate analysis, LMO continued to be one of the good prognostic parameter for survival (HR: 0.54% 95 CI 0.38-0.77. p=0.001) Conclusion: It has been shown that high LMO can be an independent prognostic parameter showing long PFS and OS in patients with extensive stage small cell lung cancer.

Background: It was aimed to evaluate the oncological outcomes in patients with primary Ta, high grade pathology, to determine possible risk factors for recurrence, and to show the effect of secondary TUR (re-TUR) on oncological outcomes. Materials and Methods: Data of patients who underwent TUR-BT in our clinic between January 2000 and December 2020 were retrospectively analyzed. Patients with pTa, high grade or G3 urothelial carcinoma were included. The demographic and histopathological data, development of relapse and progression and their duration time were scanned. The patients were divided into two groups, those with and without recurrence, and those with re-TUR or not. Comparison of categorical variables was done with Pearson chi-square test and Fisher's Exact test. In quantitative data, Student's t-test was used for normally distributed variables and Mann-Whitney U test was used for others. Type I error probability was accepted as α = 0.05 for all tests. Kaplan-Meier survival curves with 95% CI were used to determine the effect of re-TUR on bladder tumor recurrence. Results: Total of 63 patients were male (87.5%) among 72 patients. 21 patients had recurrence and 4 patients had progression at 25 months of followup. Recurrence occurred in 14 patients (66.7%) within the first year. The majority of recurrent pathologies were pTa (82%) bladder tumors. Radical cystectomy and urinary diversion were applied to one of 2 patients with muscle invasion, and multimodal therapy was applied to the other. Occupational chemical exposure was statistically significantly higher in the recurrent group (p = 0.001). There was no statistically significant difference in terms of recurrence-free survival between with and without re-TUR (p=0.432). Conclusions: This study demonstrated the negative effect of occupational chemical exposure on recurrence in highgrade pTa bladder cancers. Even 5 years after the first diagnosis, recurrence and progression can be observed. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Neuroendocrine tumors are rare but constitute a heterogeneous group of tumors in terms of localization and clinical prognosis. The aim of this study was to determine the demographic charecteristics of patients with neuroendocrine tumors and prognostic factors in the clinical course of the disease in a single reference center. Material and Method: Patients with a diagnosis of neuroendocrine tumors referred to Istanbul University Cerrahpasa Medical Faculty Medical Oncology department between January 1994 and September 2015 were included in the study. The files of 110 patients were retrospectively analysed. Results: The mean age of the patients was 55±13 years and 57% were male. The most common site of origin was pancreas (30%). Seventy percent (n =77) of patients were metastatic at diagnosis and liver was the most frequent site of metastasis. While the most common symptom firstly reported by the patients was abdominal pain (51%), the rate of asymptomatic cases was 12%. When metastatic disease and tumor markers were compared, there was a significant difference among carcinoembryonic antigen levels (p =0.02). The degree of differentiation associated with neuron specific enolase levels (p =0.008). Mortality was associated with older age (p <0.001), poor differentiation (p <0.001) and presence of metastasis at diagnosis (p =0.002). In patients whose tumor markers were evaluated, high neuron specific enolase levels were associated with mortality (p =0.005). Conclusion: In our study; older age, poor diferantiation and presence of metastases at initial presentation were found to have an effect on mortality. Early diagnosis and multidisciplinary approach can provide better results in treatment of these patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: The aim of this study was to evaluate the lung-protective mechanical ventilation strategy, early enteral nutrition, negative fluid balance, and adequacy of hospital resources in our pediatric intensive care unit. Materials and Methods: This study included 32 patients who developed acute respiratory distress syndrome (ARDS) during their monitoring in the pediatric intensive care unit. Results: According to their oxygenation status, 14 patients (43.8%) had mild ARDS, nine patients (28.1%) had moderate ARDS, and nine patients (28.1%) had severe ARDS. High-frequency oscillatory ventilation was applied to three patients (9.3%), and four patients (12.5%) received extracorporeal membrane oxygenation (ECMO) support. The most common complications were nosocomial infection (31.3%) and pneumothorax (12.5%). The mortality rate was 6.3%. The survival rate was 75.0% in patients with ECMO support. The patients with a higher Pediatric Index of Mortality (PIM-2) score confronted more severe ARDS, and non-pulmonary ARDS also progressed in advanced stages. Conclusion: In patients with high PIM-2 and PELOD scores, attention must be given to the development of severe ARDS. The lung-protective mechanical ventilation support, early enteral nutrition, negative fluid balance practices, and the adequacy of hospital resources led to a successful survival rate in our study. However, multicenter randomized controlled trials are needed on this subject.

Introduction: Melanoma is a cancer arising from the malignant transformation of melanocytes. It is mostly seen in the skin, eyes, mucosal membranes, and meninges. Melanoma is one of the fastest rising of all cancers in the world.Methods: We retrospectively examined the medical records of adult patients who were diagnosed with melanoma between January 2005 and December 2013 according to the Hospital-Based Cancer Registry (HBCR) of Hacettepe University Oncology Hospital.Results: A total of 338 patients [193 (57.1%) men and 145 (42.9%) women] were included in the study. The male to female ratio was 1.3/1. The mean age of patients was 55.2±15.2 years (minimum-maximum: 16-87 years). The rate of male patients was higher in patients with cutaneous and uveal melanoma (respectively, 56.8% and 58.6%), whereas the rate of female patients was higher in patients with mucosal melanoma (female: 55.6% and male: 44.4%; respectively, p=0.746 and p=0.518). The median follow-up time was estimated to be 27.7 months (1-103 months). During follow-up period, 127 (37.6%) patients died, and 16 (4.7%) patients were lost to follow-up. The median overall survival time was 76.3 months. The 5-year survival rate was 53%. When all patients were evaluated according to melanoma subtypes, patients with melanoma of unknown primary origin had the lowest median survival time (6.4 months).Conclusions: It is necessary to increase the awareness of people about melanoma and to make physicians more sensitive about skin examination in order to detect cutaneous melanomas in the early stages.

Amaç: Bu çalışmada miks endometrial karsinomun (MEK) klinik ve patolojik özelliklerini değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Ocak 2000 - Aralık 2019 tarihleri arasında kliniğimizde ameliyat edilen ve düzenli takip edilen 29 MEK hastasının klinik ve patolojik kayıtları gözden geçirildi. MEK grubundaki (n = 29) klinik-patolojik özellikler ve sağkalım, saf seröz (n = 42) ve saf berrak hücreli adenokarsinomlar (n = 13) ile karşılaştırıldı. Hastaların klinik bulguları, operasyon özellikleri, patolojik bulguları, miyometriyal invazyon derecesi (MI), lenf nodu tutulumu (LNI), lenfovasküler alan invazyonu (LVSI), adjuvan tedaviler ve takip verileri ve sağkalıma etkileri araştırıldı. Bulgular: Olguların 18'inde endometrioid + seröz, 7'sinde endometrioid + berrak hücreli, 3'ünde endometrioid + seröz ve 1'inde berrak hücreli+ seröz histopatoloji vardı. Hastaların ortalama yaşı 63,2 ± 12,1 yıldı. Mikst gruptaki olguların 8'ine (% 27,6) laparoskopik cerrahi uygulandı. Evre, LVSI, LNI, MI ≥% 50 ve omental metastaz oranları gruplar arasında benzerdi. Adjuvan tedavi alma oranları için gruplar arasında önemli bir fark yoktu. Genel olarak hayatta kalma süresi gruplar arasında benzerdi. Sonuç: MEK'ler, teşhis edilmesi ve yönetilmesi zor olabilen tümörlerdir. Klinikopatolojik özellikler ve prognoz açısından MEK ile saf seröz karsinom ve saf berrak hücreli karsinom arasında fark yoktu. Histopatolojik özelliklerinin yanı sıra moleküler özelliklerinin ortaya çıkarılması ve değerlendirilmesi bu grup tümörleri daha iyi anlamamıza yardımcı olacaktır.

Copyright of Medical Journal of Ankara Training & Research Hospital is the property of Medical Journal of Ankara Training & Research Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. Although curative treatment is surgery in the early stages, disease relapse is common. In this study, we retrospectively evaluated the prognostic factors and outcomes of operated NSCLC cases.Materials and Methods: Retrospective analysis of data from 166 patients with early stage NSCLC who presented after surgery and treated and followed in our clinic between 2006-2018 was performed. Histopathologic features and clinical findings were investigated as prognostic factors.The findings were analyzed using SPSS.Results: At the time of diagnosis, median age was 61 (39-82) and 84% of the patients were male. Most common pathologic subtype was adenocarcinoma. Median disease free survival (DFS) and overall survival (OS) were 76 months (%95CI:32.1-110.0) and 87 months (95%CI:59.8-114.1). ). In multivariate analysis, presence of vascular invasion was found to be independent prognostic factors for both DFS and OS (HR:2.5 and 2.3, respectively). Adenocarcinoma solid pattern was only associated with worse disease-free survival (HR: 1.7).Conclusion: In our study, we showed that the presence of vascular invasion and solid-type adenocarcinoma is associated with poor survival.

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Gümüshane Üniversitesi Saglik Bilimleri Dergisi is the property of Gumushane University, Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective This study aims to evaluate the effects of prognostic factors depending on gender and the factors affecting survival in women patients who underwent resection for non-small cell lung cancer (NSCLC). Material and Methods Patients who underwent lung resection due to NSCLC in our hospital between January 2007 and December 2018 were included in the study. 1491 patients were included in the study. Results The mean age of the patients was 60.0±8.41 (range: 26-84) years. There were 1324 (88.8%) male patients and 167 (11.2%) female patients. Pneumonectomy was performed in 406 (27.2%) patients, lobectomy in 1077 (72.2%) patients, and segmentectomy in 8 patients (0.5%). The mean 5-year survival time was 57.5%. In the study, the 5-year survival rate of female patients was 66.8%, while it was 56.4% in males (p=0.005). When the pN2 status was evaluated, the 5-year survival rate was 34.3%, while the survival rate was 64.1% in patients with pN0 (p<0.001). The most important prognostic factors affecting survival in Cox regression analysis were gender, advanced age, wider resection, pN2, and advanced stage. When the factors affecting survival in female patients were evaluated in the subgroup analysis, the 5-year survival rate was 32.9% in patients aged 65 and over (p<0.001). When the histopathology was evaluated, the 5-year survival rate was 67.1% in adenocarcinomas, while 70.7% in squamous cell cancers. Conclusion As a result of our study, the main histopathological cell type seen in female patients is adenocarcinoma. Especially in women, advanced age, large cell cancers, advanced stage, and pN2 status are poor prognostic factors in survival. [ABSTRACT FROM AUTHOR]

Aim:Ovarian cancers, 20% of which are hereditary, are considered the most lethal gynecological malignancies. Defects on DNA mismatch repair (MMR) genes are responsible for hereditary ovarian tumors related with Lynch syndrome. In this study, we aimed to determine microsatellite instability status in invasive and borderline epithelial ovarian tumors diagnosed via immunohistochemistry in our clinic and compare the results with several prognostic parameters and survival.Methods:In this retrospective study, 159 epithelial ovarian tumors were evaluated for age, tumor type, histological grade and Federation of Gynecology and Obstetrics (FIGO) stage as well as survival. MMR protein expression was immunohistochemically examined and absence of nuclear staining in tumor cells was considered MMR protein expression loss. All prognostic parameters were compared and analysed statistically.Results:MMR protein expression loss showed no statistically significant relationship with FIGO stage, age, histological grade, and survival. The only correlation was detected between tumor type and MMR protein loss (p

This work reports the survival status of Listeria monocytogenes, Escherichia coli O157:H7, Staphylococcus aureus and Salmonella Typhimurium in homemade fig and mulberry vinegar. Each pathogen was separately inoculated in vinegar samples at approximately 7 log CFU/mL. The survival status of pathogens was examined at 20°C for 0, 15, 30 and 60 min, and 4, 8 and 24 h. The residual populations after 24 h were below detection limit for all species assayed. S. Typhimurium was much more sensitive to mulberry vinegar ( 6 log reduction in 30 min) than it is to fig vinegar ( 6 log reduction in 24 h). L. monocytogenes had an overall quite different behaviour, being the most sensitive species to fig vinegar ( 6 log reduction in 4 h) while being the most resistant one to mulberry vinegar ( 6 log reduction in 24 h). The total phenolic content of fig vinegar (767 mg GAE/L) was higher than mulberry vinegar (557.5 mg GAE/L). The results exhibited that antimicrobial activity of vinegar is mainly related to the contact time, test pathogen and physicochemical properties of vinegar.

Aim:Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting disease-free survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST).Methods:This was a retrospective analysis of 34 patients with resectable gGIST who were followed up and treated at the oncology clinic between 2008 and 2019. Patients with metastatic disease and non-gastric disease and those aged

Amaç: Bu çalışmada obez düşük grade endometroid endometrial kanserde pelvik lenfadenektomiye paraaortik lenfadenektomi eklenmesinin sağkalıma olan etkisini araştırmaya amaçlanmıştır.Gereç ve Yöntem: Opere edilen endometrium kanserlerinin patoloji raporları ve birimin bilgisayar kayıtları ile arşiv dosyaları retrospektif bir şekilde tarandı. Bu süre içerisinde tüm bilgilerine ulaşılabilen hastalardan, Vücut Kitle İndeksi (VKİ) >30 kg/m2 ve endometroid histolojiye sahip olan hastalar tespit edildi. Bu vakalardan sadece lenf nodu diseksiyonu yapılmış olanlar çalışmaya dahil edildi. Hastalar uygulanan lenfadenektomiye göre iki gruba ayrıldı; sadece pelvik lenfadenektomi ve pelvik-paraaortik lenfadenektomi. Grupların demografik, klinik, cerrahi, patolojik, takip ve sağkalım bilgileri analiz edilip karşılaştırıldı.Bulgular: Çalışmanın kriterlerine uygun 290 hasta tespit edildi, bunlardan lenf nodu diseksiyonu uygulanmayan 207 vaka çıkarıldıktan sonra, çalışma pelvik lenfadenektomi grubunda 34 ve pelvik-paraaortik lenfadenektomi grubunda 49 hasta ile yürütüldü. Genel olarak her iki grubun klinik, cerrahi ve patolojik özellikleri benzerdi. Beş yıllık hastalıksız sağkalım sırasıyla %80 ve %86.3, beş yıllık toplam sağkalım ise, %92.6 ve %86.3 idi.Sonuç: çalışmaya alınan bu özel hasta grubunda, lenf nodu diseksiyonu planlanması halinde, pelvik lenf nodu diseksiyonuna paraaortik lenfadenektominin eklenmesi sağkalıma katkı sağlamayabileceği düşüncesindeyiz

Amaç:The aim of the present study was to determine the changes in the incidence of cancer in a city of Turkey, which is in the Nomenclature of Territorial Units for Statistics- 2 (NUTS-2) region, and to perform survival analysis on these patients.Gereç ve Yöntem:The present study is a retrospective cohort study. The data of the patients were obtained from the Ministry of Health's Cancer Registry System. The data of 977 cancer cases diagnosed in 2013-2015 were examined. Bulgular:28.7% of the patients died during the follow-up period. 30% of all cancers originated from the digestive system. While the cancers of lung, stomach, colon, prostate and skin are the mostly seen in the male patients, the cancers of breast, thyroid and skin are the mostly seen in the female patients. The incidence of cancer is increasing over the years and the cancer incidence rate is higher in men. The mean follow-up period was 388 days in died patients and 1541 days in alive patients. The risk of death is increasing in the patients not undergoing surgery (RR = 2.779, HR = 3.048). In addition, the risk of death is decreasing in the patients not receiving chemotherapy (RR = 0.656, HR = 0.340). The risk of death is increasing in the patients with advanced age and the male patients.Sonuç:The incidence of cancer is increasing. It is recommended to conduct longer-term and more broad-based studies evaluating the treatment efficacy and the effects of treatment types on survival.

Amaç: Bu çalişmanın amacı Wilms tümörlü (WT) hastaların tedavi sonuçlarını değerlendirmektir.Gereç ve Yöntem: 2012-2017 yılları arasında WT tanılı 21 hastanın klinik kayıtları geriye dönük olarak incelendi. Yaş, uyruk, semptomlar, teşhis ve cerrahi methotlar, cerrahi komplikasyonlar, hastalığın evresi, neoadjuvan kemoterapi durumu, radyoterapi durumu, rekürren hastalığın varlığı, tümörün histopatolojik özellikleri ve hastaların sonuçları analiz edildi. Bulgular: Kız/erkek oranı 2/1olup, ortalama yaş 4.21±2.26 yıldı. En sık saptanan fizik muayene bulgusu abdominal kitle idi. Hastaların %90,5’ine radyolojik bulgular ve klinik muayene ile tanı konuldu. Hastaların tamamına total nefroüreterektomi uygulandı. Hastaların %81’inde saptanan histopatolojik alt grup klasik Wilms tümörü idi. Hastaların %6,8’inde tanı anında uzak metastaz olup en sık uzak metastaz yeri akciğerdi. Hastaların genel sağkalımı (OS) %85,7 idi ve ortalama sağkalım süresi 36 aydı(2 ay-62 ay). Tanı anında ileri ever hastalık olması, uzak metastaz varlığı ve difüz anaplastik histoloji ile sağkalım oranları belirgin olarak etkilenmekteydi.Sonuç: Literatürdeki verilere benzer şekilde, çalışmamızın bulguları Wilms tümöründe ileri evre, uzak metastaz ve yaygın anaplastik histolojinin sağkalım üzerindeki olumsuz etkilerini doğrulamıştır. Uygun tedaviye karar vermek ve prognozu daha kesin olarak belirleyebilmek için tümörün moleküler özelliklerini araştıran büyük ölçekli çalışmalara ihtiyaç vardır.

Trisomy 14 mosaicism is a rare chromosomal abnormality with distinct and recognizable clinical features. Congenital heart anomalies can accompany in this syndrome. To the best of our knowledge, this is the first case of mosaic trisomy 14 with an aortopulmonary window to be described in the literature.

Aim:Liver transplantation (LT) is performed for several indications in the pediatric population, including malignancy and acute hepatic failure among others. LT has become an important treatment alternative for metabolic diseases. In most pediatric transplant centers, metabolic liver disease is the second most common indication for LT after biliary atresia. Our studies aim is to compare the post-transplant outcomes of those patients with metabolic and other liver diseases in our transplant program.Materials and Methods:One hundred eighty-nine patients who underwent LT between 1997 and 2015 due to metabolic diseases and acute or chronic liver failure were included in the study. This study was performed retrospectively.Results:We enrolled 189 patients in our study. 54% (n=102) male and 46% (n=87) female patients were included in the study. The metabolic disease group included 56 patients and the non-metabolic disease group contained 133 patients. Progressive familial intrahepatic cholestasis is the most common disease among metabolic diseases resulting in LT and Wilson disease is the second most common. Post-transplant immunosuppression was similar for both groups. There was no difference in both groups regarding the onset of post-transplant complications for graft type or recipient age. Biliary and portal vein complications were most particularly defined in the group with non-metabolic diseases. There was no significant difference in survival between the two groups.Conclusion:LT is an important treatment option for acute hepatic failure and end-stage liver diseases. In addition, LT is an alternative treatment option for some metabolic diseases.

Aim:We aimed to evaluate the effect of different parameters on survival in patients with gastric adenocarcinoma who underwent D2 lymph node dissection with more than 15 lymph nodes.Methods:A total of 161 patients with gastric adenocarcinoma, who underwent curative gastrectomy and had more than 15 lymph nodes dissected between January 2001 and January 2015, were retrospectively evaluated. A hundred and forty-six patients were included in the study.Results:The mean follow-up period was 24 (12-102) months and the mean survival time was 818.80±692.42 (66-3065) days. Gender, age, lymphovascular invasion and perineural invasion, tumor differentiation and histology were not found to have a statistically significant effect on overall survival. Length of hospital stay, tumor location, extent of surgery, chemotherapy, tumor stage (T category), total number of harvested lymph nodes, number of metastatic lymph nodes, lymph node status (N status), percentage of lymph node positivity, metastatic lymph node ratio and stage were found to have a statistically significant effect on overall survival.Conclusion:Having distally located tumor, having chemotherapy, higher total number of harvested lymph node and lower N category were better prognostic factor for overall survival in gastric cancer patients having curative resection with more than 15 lymph nodes harvested.

Objective: Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor in adults. Optimal treatment is adjuvant concomitant chemoradiotherapy following the widest possible surgical resection (maximum safe resection) followed by adjuvant chemotherapy. However, the geriatric group is not treated optimally. Recent studies have shown that optimal treatment benefits in the older group, similar to those in younger patients. We aimed to investigate the effect of optimal treatment on survival in patients 65 years of age and older with GBM. Methods: In Pamukkale University Medical Oncology Clinic, the files of 71 patients with a pathological diagnosis of GBM between 2010 and 2018 were retrospectively evaluated. Demographic and clinicopathological characteristics of the patients were recorded from the file. Results: Of the 71 patients evaluated, 25 (35.2%) were 65 and over, 46 (64.8%) were under 65 years old. Of the twenty-five patients, 11 (44%) were male and 14 (56%) were female. Median follow-up time was 16.2 months (12.4-19.9) and median overall survival time was 12.5 months (10.4-14.7) in all patient groups. The median overall survival of patients under the age of 65 years was 15.1 months (12.6-17.6 months), and patients aged 65 and over were 8.6 months (7.9-9.3 months) (p <0.001). The median overall survival was 8.9 months (8.4-9.4 months) in patients 65 years and older who received optimal treatment, while the median overall survival was 7.9 months (3.4-12.4 months) in patients who did not (p:0.048). Conclusion: The median overall survival time of patients 65 years and older who received optimal therapy was significantly longer than those who did not. It has been observed that survival outcomes are improved when elderly patients with good performance can receive optimal treatment like younger patients. [ABSTRACT FROM AUTHOR]

Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: To evaluate the mid-term treatment results in early-stage squamous cell carcinoma (SCC) of the lower lip and to investigate the effect of tumor depth and size on neck metastasis. Methods: The study included 52 patients who were operated between 2010 and 2017 for early-stage primary SSC of the lip with negative surgical margins and without oral commissure involvement T1 and T2 without lymph node or distant metastasis. Patients with missing data or patients with a history of additional malignancy at the time of diagnosis were excluded from the study (n=13). The data of the remaining 39 patients were further analyzed. Results: Fifteen patients (38.5%) were identified as having pT1 and 24 patients (61.5%), pT2. The mean tumor size was 16.8 mm and the mean invasion depth was 6.3 mm. Neck dissection was performed in 22 (56.4%) patients (6/15 pT1 patients and 16/24 pT2 patients). Lymph node involvement was reported in two (9.09%) of 22 patients. Both patients had pT2 stage tumors. Recurrence was observed in one patient (patient with pT2 tumor). The 5-year survival rate was calculated as 82.05%. Conclusion: In early-stage SCC of the lower lip, a tumor size greater than 21.5 mm and depth of tumor invasion greater than 7 mm are associated with increased neck metastasis. Elective neck dissection should be performed in these high-risk patients. [ABSTRACT FROM AUTHOR]

Aim: Gastrointestinal stromal tumors (GISTs) are extremely rare. In this study, we aimed to analyze the factors affecting diseasefree survival (DFS) in patients operated for non-metastatic gastric GIST (gGIST). Methods: This was a retrospective analysis of 34 patients with resectable gGIST who were followed up and treated at the oncology clinic between 2008 and 2019. Patients with metastatic disease and non-gastric disease and those aged <18 years were excluded. Results: Seventeen (50%) patients were male. The median age was 64 years. According to Miettinen Risk Scores, seven patients were (20.6%) in very low-risk group, five (14.7%) in lowrisk group, 17 (50%) in moderate-risk group, and five (14.7%) patients were in high-risk group. Adjuvant therapy was given in 11 (32.4%) patients. The 5- and 10-year DFS rates were same as 79.2%. The 5- and 10-year overall survival rates were 90.9% and 85.6%, respectively. In multivariate analysis, presence of necrosis [Hazard rate (HR)=9.5], being in high-risk group (HR=27.2), Ki- 67 (HR=1.03), and receiving adjuvant therapy (HR=0.51) were factors affecting DFS. Conclusion: We assume that adjuvant therapy should be given in high-risk patients operated for gGIST in the presence of necrosis and high Ki-67. [ABSTRACT FROM AUTHOR]

Objective: Our study was planned to investigate the clinical, radiometabolic (PET-CT), and survival properties of primary lung cancer with cavitary. Material and Method: The files of patients diagnosed as primary lung cancer in our clinic between 2014 and 2016 were examined. The cases were divided into two groups as primary lung cancer with cavity and without cavity. Demographic, radiological, clinical, radiometabolic and survival properties of both groups were recorded. The data of both groups were compared with each other. Results: A total of 323 cases with a mean age of 61.6 ± 9.8 years were included in the study. There were 36 primary lung cancer cases with and 287 lung cancer cases without cavity. The rate of primary lung cancer with cavity was 11.1%. The rate of cavitation was significantly higher in squamous cell carcinomas (p =0.024). The size of lung cancer with cavity (65 mm) was greater than lung cancer without cavity (50 mm) Mean, maximum (p =0.001). Median overall survival in cavitary cancers was 14 ± 2.7 months. In non-cavitary cancers, this time was 12 ± 0.8 months (p =0.887). Otherwise, age, gender, smoking history, cancer stage, treatment characteristics, radiometabolic properties and survival were similar in both groups (p >0.05). Conclusion: The most common cavitation in lung cancers is seen in squamous cell cancers. Clinical, radiometabolic and survival characteristics of cavitary lung cancers are similar to those of noncavitary lung cancer. [ABSTRACT FROM AUTHOR]