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Introduction:Elevated transaminases has been frequently observed in pediatric emergency department admissions due to increasing utilization of routine laboratory packages. There are limited data about clinical features, underlying conditions and clinical course of these patients. This study aims to evaluate clinical characteristics, etiologies, recovery time and length of stay in hospital of children with elevated transaminases in pediatric emergency department.Methods:We included 1-month- 18-year-old children who were followed in observation unit of Pediatric Emergency Department of University of Health Sciences Turkey, Dr. Behçet Uz Pediatrics and Surgery Training and Research Hospital and had increased transaminases between 2016 January and 2017 January. Increased aspartate aminotransferase and alanine aminotransferase were defined as values above 60 U/L and 45 U/L. The clinical and laboratory data were obtained retrospectively from electronic medical records.Results:We included 89 patients. The median age was 36 months (1-216 months). The most common symptoms were vomiting (n=31), fever (n=27) and abdominal pain (n=25), the most frequent physical examination finding was dehydration (n=20). Etiologies were infections (40.5%), metabolic disorders (11.2%), drug induced liver injury (9.0%), hepatobiliary diseases (5.6%), others (9.0%) and unexplained in 24.7%. Transaminases were elevated under 5 times in 62.5%. N-acetylcystein and ursodeoxycolic acid were administered in 9.0% and 18.0%. The median recovery time was 5 days (1-61 days) and length of stay was 3.7±9.2 days. Recovery time and length of stay were not significantly different according to etiologies (p=0.107 and p=0.952).Conclusion:This study has indicated that mild elevation of transaminases is common in pediatric emergency department. Although most common reason is infections, it can be related to various conditions such as trauma and inherited metabolic disorders. Also, we have found that the recovery time is short and does not change according to etiologies. However, multi-center studies in a large population are still required to form algorithms for the assessment of elevated transaminases in pediatric emergency department .

Objective: in this study we evaluate our aseptic meningitis patients regarding age group, sex, clinic sign of meningitis, recovery time of disease, patients hospital length of stay, cerebrospinal fluid (CSF) findings. Material and Methods: During the period of June-August 2009 in Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinics of Pediatry, 29 aseptic meningitis patients were treated and retrospectively evaluated epidemiologically, clinically and laboratory findings (CSF microscopic and biochemical evaluation). Findings: All patients were between 1 month and 10 year old and mean age was 4.67±2.84 year old. 22 of patients (75.9%) are male, 7 of patients (24.1%) are female. Male/femaie ratio was calculated as 3.15. Complaints of patients who were admitted to the hospital were fever (89.7%), nausea-vomiting (82.89%) and headache (9665.5). In the physical examination 79.3% of patients had got meningeal irritation findings (neck sifness, Kernig sing, Brudzinski phenomenon). Only 1 patient had ataxic walking. Results: The length of aseptic meningitis patients hospital stay depends on patients' clinic recovery more than CSF findings recovery. CSF findings recovery may took more time than clinic recovery time. In our evaluation the aseptic meningitis patients' hospital discharge is more dependent on clinic recovery than the CSF findings recovery [ABSTRACT FROM AUTHOR]