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Aim: Kidney disease is common in older adults due to age-related structural and functional changes in the kidneys, higher rates of chronic disease, and increased drug use. As societies age, there is a rise in the prevalence of renal disease and the number of kidney biopsies being performed in older patients. This study aimed to investigate renal biopsy indications, complications, pathology results, and subsequent treatment among older adults in Turkey. Materials and Methods: We retrospectively analyzed data from patients aged 65 and over who underwent renal biopsy in a university nephrology department between 2004 and 2023. The patients’ demographic information, chronic comorbidities, biopsy indications, pre-biopsy laboratory values, post-biopsy complications, pathology results, and post-biopsy treatments were obtained by reviewing their medical records and biopsy reports. Results: A total of 66 patients were included in the study. The median age was 73.0 years (IQR: 68.8-79.0 years) and 66.7% of the patients were men. The most common comorbidities were hypertension (83.3%), diabetes mellitus (24.3%), coronary artery disease (22.7%), and chronic kidney disease (21.2%). The most common indication for renal biopsy was nephrotic-range proteinuria (56.1%), followed by acute kidney injury (24.2%). When the pathology results were examined, primary glomerulonephritis (62.1%) was the most common result, followed by secondary glomerulonephritis (21.2%) and tubulointerstitial nephritis (12.1%). The most common histopathological diagnoses in primary glomerulonephritis were membranous glomerulonephritis (39.4%) and focal segmental glomerulosclerosis (12.1%), while those in secondary glomerulonephritis were secondary amyloidosis (9.1%) and lupus nephritis (4.5%). After biopsy, 54.5% of the patients received immunosuppressive therapy and 34.8% received renal replacement therapy. No post-biopsy complications were observed. Conclusion: Although the most common indication for kidney biopsy in older adults is nephrotic-range proteinuria. Kidney biopsy is the gold standard method for the diagnosis of renal parenchymal diseases and is a safe procedure in older patients, with low complication rates. Kidney biopsy should not be avoided in geriatric patients if deemed clinically necessary.

Aim: The number of studies examining the frequency of Helicobacter pylori (Hp) infection, Hp antigen (Ag) test in the stool together with endoscopy and pathology findings in the elderly is limited in the literature. The aim of this study was to investigate the frequency of Hp Ag positivity in the stool samples of elderly patients who checked in to the internal medicine clinics of our hospital with dyspepsia and its relationship with age, gender, seasonal changes, endoscopy and pathology findings. Materials and Methods: The data of the geriatric patients whose stool samples were investigated for the presence of Hp Ag who applied to the Internal Medicine Clinics of our university with dyspepsia between January 1, 2018 and January 1, 2023 were retrospectively analyzed. Besides demographic and clinical data, endoscopy and pathology reports were recorded. Results: A total of 2276 patients were included in the study. 60.3% of the patients who requested Hp Ag test were female. Of the total 592 stool samples tested, 20.3% were positive. Hp positivity was highest in the young-old group with a rate of 81.7% (p

Aim:This study aimed to evaluate mortality risk associated with readily accessible laboratory parameters and underlying conditions in hospitalized older adults.Materials and Methods:This retrospective study included geriatric patients admitted for inpatient care to the internal medicine wards of two major university hospitals in two different regions of Turkey. Data related to the patients were collected by retrospective review of patient charts and electronic records. Survival data were obtained from the Death Reporting System of the Turkish Ministry of Health. Survival after admission at 30 days and 1 year was noted.Results:The study included 1.465 hospitalized older adults with a median age of 74 years, of whom 51% were women. Of these patients, 115 (7.8%) died within 30 days and 382 (26.1%) died within 12 months. For 30-day mortality, independent risk factors appeared to be infectious diseases [odds ratio (OR) 2.109, p=0.006], receiving palliative support (OR 5.982, p=0.006), malignancy (OR 2.514, p=0.001), Charlson Comorbidity Index (CCI) (OR 1.219 per unit increase, p

Aim:To study changes in hepcidin, a key protein synthesized in the liver, following chronic viral hepatitis, cirrhosis and/or liver transplant, as well as the effect of hepcidin level variation on liver function tests and iron levels.Materials and Methods:The patient population was distributed as follows: Group 1: inactive chronic hepatitis B (n=31); Group 2: chronic hepatitis C (n=30); Group 3: decompensated cirrhosis linked to hepatitis C virus (HCV) or hepatitis B virus (HBV) (n=29); Group 4: decompensated HCV- or HBV-related cirrhosis treated by liver transplantation (n=31).Results:The following characteristics were unequally distributed among the groups: age, Hb, AST, ALP, LDH, T. bil, albumin, total cholesterol, HDL, serum total iron binding capacity, and transferrin saturation (TS). In the two-group comparison of Groups 1 and 2, significant differences in Hb, AST, AP, albumin, and prohepcidin were observed; the latter was more elevated in HCV patients (Group 2) (p

Gastrointestinal stromal tümörler gastrointestinal sistemin nadir (%1) mezenkimal neoplazmıdır. Yerleşim yeri sıklık sırasına göre mide (%60-70), ince barsaklar, kolorektum ve özofagustur. Çapı 4 cm’den büyük, sınırları düzensiz, heterojen ekolu, ekojenik odaklar ve kistik oluşumlar içeren Gastrointestinal stromal tümörler genellikle maligndir. Seçkin tedavisi komplet cerrahi rezeksiyondur. Üst gastrointestinal sistem kanaması ile prezente olan, gastrointestinal stromal tümör saptanan, 65 yaşında, erkek hasta sunulmuştur.

Introduction: Malignant tumors of the small intestine comprise 2-3% of all gastrointestinal cancers. Adenocarcinomas account for 95% of primary small intestine malignancies. The prevalence of adenocarcinoma increases with advanced age. They are commonly located in the distal duodenum and the proximal jejunum. They are usually diagnosed coincidentally and are most effectively treated by surgery.Case Presentation: Here we present a 67-year-old female patient who underwent emergency surgery for acute strangulated hernia during which a tumoral mass was discovered in the ileum, leading to a diagnosis of adenocarcinoma of the ileum.Conclusion: The most effectively treated method is surgery in small intestine adenocarcinomas.