1. Psoriasiste dar band ultraviyole B tedavisinde haftalık düşük ve yüksek oranlı doz artış protokollerinin karşılaştırılması.
- Author
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Bıçak, Mehtap Ünlü, İlknur, Turna, Akarsu, Sevgi, Yücel, Filiz, and Özkan, Ayşe Şebnem
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PSORIASIS treatment , *DOSE-response relationship in biochemistry , *MEDICAL protocols , *MEDICAL radiology , *ULTRAVIOLET radiation , *SEVERITY of illness index , *DESCRIPTIVE statistics - Abstract
Background and Design: Considering the probable long-term side-effects of narrowband UVB (NB-UVB) therapy, various studies have been conducted to provide more effective and reliable protocols by applying the different initial doses, numbers of sessions or dose increments. The aim of this study was to compare the clinical effectiveness of weekly low-dose increments and weekly high-dose increments of NB-UVB therapy in psoriasis. Materials and Methods: Twenty-nine patients with psoriasis vulgaris underwent NB-UVB therapy with a weekly low-dose (20%) increment protocol (group 1; n=14) or weekly high-dose (40%) increment protocol (group 2; n=15). The patients were monitored weekly for 12 weeks and evaluated by the Psoriasis Area Severity Index (PASI). Results: The PASI scores prior to the therapy and during the 12-week therapy for each week between the groups were compared and no statistically significant difference was found except week 12. The mean PASI scores at week 12 was significantly lower in patients from group 2 than in patients from group 1 (p=0.045). The mean number of patients and therapy sessions required with ≥50%, ≥75% and ≥90% PASI reduction did not differ between the groups. Although comparison of the two groups according to the mean cumulative doses with ≥50% and ≥90% PASI reduction did not reveal a statistically significant difference, however, those of patients with ≥75% PASI reduction at the end of the 12-week therapy were significantly higher in the group with a weekly high-dose increment than in the group with a weekly low-dose increment (p=0.014 and p=0.00, respectively). Conclusion: Although we are aware that our results may need to be supported with large-series studies, we suggest that a weekly low-dose increment regime of NB-UVB therapy is preferable in the treatment of psoriasis as it produces nearly similar effects as a weekly high-dose increment regimen but with the lower cumulative doses. (Turkderm 2015; 49: 101-6) [ABSTRACT FROM AUTHOR]
- Published
- 2015
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