Search

INTRODUCTION: This study was conducted to determine the epidemiological characteristics, quality of life, treatment modalities and efficacy of our treatment in patients with pulmonary arterial hypertension (PAH). METHODS: Fifteen patients (11 girls, 4 boys) who were followed up for PAH in the Department of Pediatric Cardiology between January 2008 and December 2016 were evaluated retrospectively. RESULTS: The mean age of patients at first admission was 10.7±5 (3-20) years. Only one of the patients (7%) had primary PAH, and two patients (13%) had PAH associated with chronic lung disease. Twelve patients (80%) had PAH secondary to congenital heart disease. Of these patients, 10 had Eisenmenger syndrome and two were operated for congenital heart disease with a left to right shunt. Six patients (60%) had VSD, and two (20%) had atrioventricular septal defect in 10 patients with Eisenmenger syndrome. The most common symptom was easy fatigue (83%). All of the patients had telecardiography, electrocardiogram and echocardiography, and 87% of patients underwent six minute walking test and angiography. All patients undergoing angiography were tested for vasoreactivity and all were negative. When the treatments at the last controls of the patients are evaluated; 53.3% of the patients received monotherapy, 46.7% received combination therapy. The most frequently started monotherapy was bosentan (46.7%). Four patients were died during follow-up. DISCUSSION and CONCLUSION: Pulmonary arterial hypertension is a chronic progressive disease that can be caused by many etiologic factors. If not treated; progressive increase in pulmonary vascular resistance leads to right ventricular failure and premature death. Accumulating PAH patients in experienced centers will ensure appropriate diagnosis, follow-up and treatment options. © 2018, Galenos Yayincilik. All rights reserved.

Background and Design: In this study, we aimed to evaluate the efficacy, safety and side effects of infliximab therapy in patients followed up in our clinic with moderate-severe psoriatic patients unresponsive to conventional therapies. Material and Method: Twenty-six psoriasis patients who were given infliximab therapy in our clinic between years 20062008, were retrospectively analyzed for their demographical clinical features, changes in PASI score, duration, efficacy and adverse effects of the therapy. Results: There were 15 female and 11 male psoriasis patients; ages ranging from 18 to 70 years (45.2 +/- 12.9). 17 of them were diagnosed as generalize plaque type psoriasis, 2 as eritrodermic psoriasis, 5 as generalize pustular, two of them as palmoplantar pustular psoriasis. Thirteen have associated psoriatic arthritis. All patients received 5 mg/kg intravenous infliximab infusion at weeks 0, 2, and 6, followed by every 8 weeks. Number of infliximab therapy sections was ranging from 2 to 16 and duration of treatment from 1 month to 28 months. Improvement in PASI between pretreatment and after induction therapy was statistically significant (p

Introduction: The aim of this study was to see the effects of ischemia-reperfusion injury on reactive oxygen species (ROS) in acute urinary retention and to determine whether these effects would be normalized by different antioxidant agents. Materials and Methods: We used 37 male Wistar Albino rats in our research. We formed five groups totally, as a combination of 1 sham, 1 retention and 3 treatment groups including 5, 8, 8 male rats in each group respectively. In the treatment groups allopurinol and/or verapamil were used. After clamping the rat penile urethra, diuresis was forced and overdistension was maintained. After 30 minutes under overdistension the rat's bladder was emptied with 3F catheter. After reperfusion of their bladders and waiting for 30 minutes in this condition, the rats were sacrificed. Bladder tissue samples were taken and malondialdehyde (MDA) & myeloperoxidase (MPO) measurements were made. Results: In the retention group both MDA and MPO levels were increased significantly when compared with the sham group. In the treatment groups, decreases in MDA and MPO levels were found statistically important when compared with the retention group. We didn't find any significant difference between treatment and sham group, and within the treatment groups. Conclusion: The MDA and MPO increase in the retention group show that the decompression following acute urinary retention, leads ischemia reperfusion injury in the bladder and leukocytes have a role in this injury. We found that both allopurinol and verapamil were effective in decreasing the injury and the combination of these agents, compared with the mono-treatment, didn't make any additional benefit.

Nöbet türüne uygun olarak seçildiğinde tek bir antiepileptik ilacın birden fazla antiepileptik ilacın kullanımı kadar etkili olduğu ve ayrıca yan etki ve toksisile insidanslarının daha düşük olduğu bildirilmektedir. Bu çalışmada jeneralize nöbeti olan ve karbamazepin ve fenitoin kullanan erişkin epileptik hastalarda monoterapi sonuçlarının incelenmesi amaçlanmıştır. Bu amaçla jeneralize nöbetleri olan ve fenitoin (150 olgu) veya karbamazepin (101 olgu) monoterapi alan toplam 251 erişkin hasta prospektif olarak incelenmiştir. Son doz ayarlamasından sonra en az 12 aylık takip süresi sonunda her iki grupta nöbet frekansında ki azalma ve yan etkiler incelendi ve iki grubun bulguları karşılaştırıldı. Nöbetlerin kontrol altına alınmasında fenitoin hastaların% 77. 3 'ünde, karbamazepin ise% 74. 3 'ünde etkili bulundu. Fenitoin alan hastalarda yan etkiler biraz daha sık görüldü (fenitoin grubunda % 16. 7, karbamazepin grubunda % 14.8). Sonuç olarak tedavi etkinliği ve yan etki insidansı bakımından iki grup arasında anlamlı fark bulunmadı. If chosen appropriately, anticonvulsant drug (ACD) monotherapy is effective at least as combinations of ACDs with the advantage of tower incidence of side effects and toxicity than polytherapy. In this study we aimed to investigate results of phenytoin and carbamazepine monotherapy in adult patients with generalized epilepsy. In this prospective study we included 251 adult patients with generalized seizures who were under phenytoin (150 cases) or carbamazepine (101 cases) monotherapy. At the end of the follow-up period of at least 12 months, we evaluated reduction in seizure frequency and side effects, and compared results of two groups of ACD monotherapy. We found that phenytoin is effective in 77.3 %, and carbamazepine in 74.3 %of patients. Side effects were seen slight/y morefrequent/y in phenytoin group than carbamazepine group (16. 7% ve 14.8% respectively). There were no significant differences in regard to therapeutic efficacy and side effects between phenytoin and carbamazepine groups.