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Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE)- mediated food allergy. However, the exact pathophysiology of FPIES is not clearly understood, cell mediated mechanisms are considered to be responsible. FPIES is classified in two forms: acute and chronic. There are no diagnostic laboratory tests for FPIES but laboratory methods can be used for other diseases in the differential diagnosis. The diagnosis of FPIES is based on clinical responses to elimination of suspected diets with resolution of symptoms, oral food challenges with reappearance of symptoms following provocation test by providing the offending food. Acute FPIES can be confused with other frequently seen childhood diseases. In this review, the clinical findings, diagnosis, diseases included in the differential diagnosis, treatments and follow-up of FPIES are examined in the light of the latest publications and recommendations. [ABSTRACT FROM AUTHOR]

Food protein induced enterocolitis syndrome (FPIES) is a non immunoglobulin (Ig) E mediated gastrointestinal food hypersensitivity. Diagnosis is based on the history, clinical features, exclusion of other etiologies and food challenge. Management relies on the avoidance of any offending food. Herein we represent a twelve month-old boy who was believed to have had an IgE mediated food hypersensitivity after the ingestion of cow's milk based formula but who was diagnosed as FPIES after food challenge. [ABSTRACT FROM AUTHOR]