The issue of the nature of existence is directly related to the way in which man deals with existence. What makes a difference between the schools in the history of philosophy is their attitudes towards this issue. In the thought of Nicholas of Cusa, existence is not something that a person can realize with purely epistemic abilities. Therefore, Absolute Being cannot be grasped in its own perfection as it is. What is primarily necessary for this is a kind of intellectual purification in which the reason renounces all affirmative claims of knowledge. This actually is a state of consciousness and the intellect that reaches this level contemplates existence at its source. In this state, where opposites appear in harmony and plurality in unity without any contradiction, God is no longer a subject of knowledge but a subject of experience. According to Cusa, only an intellectual comprehension can be achieved with a mystical view of being based on the inner experience of the human being in this way. The main thing is not knowing anymore but knowing that you can never know. According to Cusa, the way to reach this level of understanding is divine grace as well as spiritual education. Cusa’s philosophy, as a method and general approach, took its origin from Plato's philosophy, was shaped by the mystical theological views of Pseudo-Dionysius, and was influenced by philosophers such as Proclus, Erigena, and Augustine. The most distinctive feature of this philosophical tradition is the dialectical method inherited from Plato. Cusa, who has determined his primary goal in both his academic and professional careers as realizing harmony between differences, has also reflected this unifying attitude in his philosophical and theological views, and has used the dialectical method effectively in this context. The importance of the dialectical method cannot be denied in the formation of the theory of "unity of opposites", which he based on De Docta Ignorantia, which is considered to be his masterpiece, and elaborated on it from different angles in other works he wrote later. The dialectical understanding, which dominates the whole of Cusa philosophy, is revealed through the teaching of "the learning of ignorance" (de docta ignorantia) in his epistemology. Although “ignorance”, which is the essential element of the composition in the concept, seems to bring a negative emphasis to the fore, this negativity implies the necessity of an experiential divine vision that goes beyond a discursive theology that can be built on a purely conceptual basis, not as an absolute and final situation, but as a temporary and instrumental situation. Thus, Cusa, who brings together ignorance and knowledge in a common conceptualization, evaluates these two seemingly contradictory situations as an effort to gain a holistic understanding of existence to emphasize a cognitive activity that goes beyond speculative reason. While this level of comprehension admits that the truth of things is inaccessible with language and thought possibilities due to the inadequacy of the human mind, it accepts this comprehension as the solution itself. This level of comprehension, where thesis and antithesis appear in harmony, opens to human comprehension as an effort to see beyond the contradictions in the world. Cusa advocates a point of view that opposes the limitation of epistemic possibilities of man, who is a finite knower, to mere appearances. Thus, he opposes the approaches that make the knowledge of the particular absolute, and he thinks that such knowledge narrows the possibility of a universal perspective on existence. The thing that Cusa, who is described as a skeptic because of this attitude, doubts and thinks that he has become aware of as a result of this doubt, is not the possibility of knowledge of the being, but the inadequacy of the knowledge of the particular against the universal knowledge of the being. Here Cusa calls this awareness a kind of ignorance, and the effort to realize this ignorance is "the learning of ignorance". According to Cusa, the eye sees but does not know unless there is a power of discernment that turns seeing into knowing, that clarifies and perfects it. The mind makes inferences using sensory data. However, unless there is realization, it cannot know what it infers. The fact that the mind acquires this power is because of the Original, of which it is the manifestation, and God is the origin of all manifestation. Therefore, when it manifests in the mind, the originals of the things it contains agree with the object in the mind, and the knowledge in the state of potency is transformed into action in and by the mind environment, and the activity of making judgment takes place. Cusa likens it to the reflection of light in different colors on things, reflecting off the delicately sharpened tip of a masterfully polished diamond. Reaching an opinion about the forms of things by looking at its tip and being able to notice the effect of the diamond by seeing the similarity between the light reflected from it and the things, means activating the mind with the dimension of comprehension. Cusa's emphasis on ignorance in the face of truth should not be regarded as a kind of fideistic attachment as Cusa explains ignorance not as a mere value, but as a competence that can be obtained after reaching a certain level of comprehension. As a matter of fact, he insists that unknown things cannot be truly loved. Where there is no love, there is no real faith. The leap of faith that takes place as a result of this is never considered an unjustified and arbitrary activity for Cusa. He is in favor of preserving his comprehension-oriented approach to a healthy faith until the end. Making a distinction between what is contrary to reason and what is beyond reason, Cusa states that dogmas that cannot be understood empirically may well be theologically plausible. This study was conducted to address the possibilities revealed by the in-depth and versatile perspective of Nicholas of Cusa’s philosophy. In this respect, it can be said that Cusa has made a considerable contribution to the philosophical tradition in which his philosophical and theological thoughts are articulated. On the other hand, we are of the opinion that important results for the understanding of existence can be revealed by examining this philosophy in a comparative way with both philosophical and mystical thoughts that have emerged, especially in Islamic thought. [ABSTRACT FROM AUTHOR]