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Copyright of Journal of Traditional Medical Complementary Therapies is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Premature adrenarche (PA) has been associated with metabolic and polycystic ovary syndrome (PCOS) and, thus, with an increased risk for type 2 diabetes and cardiovascular diseases in later life. Mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) are parameters used to show inflammation. This study planned to evaluate systemic inflammation in children with PA using MPV, NLR, and PLR. Materials and Methods: The study included 40 female patients diagnosed with PA and 40 healthy female individuals as a control group. The patient and control groups’ MPV, NLR, and PLR values were compared. Results: The mean age of the PA group was 7.18±0.66 years, and the mean age of the control group was 7.09±1.08 years. The mean MPV and platelet distribution width (PDW) values in the PA group were significantly higher than those in the control group (10.25±0.87 vs 9.52±0.79, p0.05). The results of multivariate logistic regression analysis revealed that the MPV [odds ratio (OR); 95% confidence interval (CI): 0.331 (0.174-0.630); p=0.001], and PDW [OR; 95%: CI: 0.612 (0.425-0.884); p=0.008] were associated with PA in the patient group. Conclusion: Our results demonstrated that PA patients had significantly higher MPV levels and PDW than the healthy controls. Hence, recognition of early markers in adolescence might reveal primary pathogenetic alterations predictive of the later development of PCOS and/or metabolic syndrome.

Copyright of Izmir Katip Celebi University Faculty of Health Sciences Journal / İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi is the property of Izmir Katip Celebi University, Faculty of Health Sciene Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The role of ABCA1, one of the family of Adenosine triphosphate binding cassette (ABC) carrier proteins, is also very important in diseases such as cardiovascular diseases and cancer, which are very important and increasing day by day. ABCA1 is an integral cell membrane protein that protects from cardiovascular disease by excretion of excess cholesterol from cells and suppression of inflammation. It is also known that abnormalities in cholesterol metabolism support the development of cancer cells. This indicates that ABCA1 is also active in cancer. Although many studies have been conducted on ABCA1, there is no comprehensive bibliometric study in the literature on the subject. In this study, it is aimed to evaluate the subject by examining the scientific articles published about ABCA1. Methods: Studies published between 1975-2022 on ABCA1 were scanned from the Web of Science (WoS) database and analyzed using bibliometric methods. In addition, VOSviewer program was used to perform bibliometric analysis and visualize the obtained metadata. Results: Studies on ABCA1 started in 1993 and increased after 2000. The language used in 99.2% (n=5694) of the articles is English. The most studies on ABCA1 were done in the field of Biochemistry and Molecular Biology (n=1708, 29.4%). The United States (n=2029, 35.3%), China (n= 1198, 20.9%), Canada (n=517, 9.0%), and Japan (n=514, 9.0%) were ranked as the countries where more than 500 articles were published. Turkey, on the other hand, ranked 29th with 32 articles. 427 of the articles were cited at least 100 times. Conclusion: In this comprehensive bibliometric study on ABCA1, a summary of 5743 articles was presented. In addition to contributing to the literature in the evaluation of research on ABCA1, this article can be shown as a resource to direct the researches to be done or to advance the researches. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Health Sciences / Türkiye Klinikleri Sağlık Bilimleri Dergisi is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Centuries of using essential oils in human nutrition and health have given rise to 'Aromatherapy' and the utilization of aromatherapeutics for treating various symptoms and diseases. The medicinal properties of essential oils have also been demonstrated with the advancement of scientific investigations and research. As a result, aromatherapy has become a complementary therapy. Aromatherapy has been used to treat a variety of disorders, particularly anxiety. Cardiovascular diseases have been among the various illnesses for which aromatherapy is utilized. Considering the prevalence of diseases in society, aromatherapy - a complementary treatment system - has been used due to its indirect, if not direct, effects on this system. Research has shown that aromatherapy can help lower blood pressure and support cardiac health by increasing blood flow by dilating blood vessels. Additionally, considering the positive effects of aromatherapy on stress, it is thought that aromatherapy may improve cardiovascular health by reducing stress. For this purpose, Lavandula angustifolia Mill., Rosa damascena Mill., Cananga odorata Lam., Matricaria recutita L., Citrus limon Osbeck essential oils and mixtures of these oils are the most preferred aromatherapeutics. Aromatherapy applications are generally performed in the form of massage, inhalation or steam bath. This study evaluated and compiled randomized clinical studies in the literature. Within the framework of the results obtained, it has been demonstrated again that aromatherapy is complementary to conventional treatment in terms of both physiological and psychological support. It has been observed that aromatherapy can be a highly preferable method for patients, given its applicability and accessibility. [ABSTRACT FROM AUTHOR]

Copyright of Karya Journal of Health Science is the property of Karya Journal of Health Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of SPORMETRE: The Journal of Physical Education & Sport Sciences / Beden Eğitimi ve Spor Bilimleri Dergisi is the property of SPORMETRE: The Journal of Physical Education & Sport Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Necmettin Erbakan University Dental Journal (NEU Dent J) is the property of Necmettin Erbakan University Dental Journal (NEU Dent J) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Foods can be classified into four subcategories according to the NOVA food classification. In this literary review, our aim was to investigate the common health effects of NOVA Category 4 ultra-processed foods which include carbonated beverages, packaged savory and sweet snack products, reconstituted animal products (such as salami, sausages, ground meat products), pre-prepared foods, pre-cooked and frozen foods. The consumption of ultraprocessed foods is increasing due to taste, accessibility, and lower costs. However, this increase causes malnutrition and contributes to various non-communicable diseases such as type-2 diabetes, obesity, cardiovascular diseases, gastrointestinal diseases, and cancer, contributing to increased rates of morbidity and mortality. For this reason, it is important to develop new nutrition policies and guidelines at the national and international level in line with the available data. [ABSTRACT FROM AUTHOR]

Copyright of Food Science & Engineering Research is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of ESTUDAM Public Health Journal is the property of ESTUDAM Public Health Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of MN Opthalmology / MN Oftalmoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of MN Cardiology / MN Kardiyoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Obstructive sleep apnea syndrome (OSAS) is a common disorder that results from the collapse of the upper airways during sleep and causes temporary hypoxia. OSAS and hypertension are common and multifactorial diseases. aim This study aimed to determine the clinical, demographic, polysomnographic and prognostic features of OSAS patients with hypertension. Materials and Methods: In this study, 364 patients diagnosed with OSAS in the sleep laboratory of the Department of Neurology, Bursa Uludağ University Faculty of Medicine between 2016 and 2021 were retrospectively scanned and included. The patients were analyzed by comparing them with and without hypertension. Results: When patients with and without hypertension were compared according to clinical, demographic and polysomnography data, age (p<0.001), sex (p=0.009), presence of diabetes mellitus (DM) (p<0.001), presence of coronary artery disease (p<0.001), presence of heart failure (p=0.020), presence of atrial fibrillation (p=0.004), ischemic stroke (p<0.001), minimum oxygen saturation (p=0.015), oxygen desaturation index (p=0.034) and body mass index (BMI) (p<0.001) were statistically significantly correlated. When the significant variables were analyzed with binary logistic regression, the most significant variables were age [p<0.001, odds ratio (OR): 1.07], DM (p<0.001, OR: 7.58), coronary artery disease (p=0.003, OR: 4.92), heart failure (p=0.041, OR: 5.53), ischemic stroke (p=0.042, OR: 3.38) and BMI (p<0.001, OR: 1.28). Conclusion: In this study, we found that cardiovascular diseases such as coronary artery disease, heart failure and ischemic stroke are more common in OSAS patients with hypertension, and this is independent of risk factors such as age, DM and BMI. OSAS and cardiovascular diseases may show ethnic and racial differences. For this reason, we suggest conducting multicenter prospective studies examining the effects on blood pressure regulation and cardiovascular diseases in our own population. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Sports Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Physical Medicine & Rehabilitation Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkiye Klinikleri Journal of Health Sciences / Türkiye Klinikleri Sağlık Bilimleri Dergisi is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Bu çalışmada Aspirin kullanımın amaçlarına yönelik bir değerlendirme yapmak ve hastalarda konuya ilişkin farkındalık oluşturmak amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Sağlık Bilimleri Üniversitesi Antalya Eğitim ve Araştırma Hastanesi Aile Hekimliği Polikliniği’ne başvuran ve yaşamı boyunca en az bir kez Aspirin kullandığını belirten hastalar dahil edildi. Hastaların Aspirin kullanma nedenleri sorgulandı ve hastalar hekim önerisi ile ve hekim önerisi olmadan Aspirin kullananlar olarak iki gruba ayrıldı. Hastalara Aspirin kullanım durumları ve klinik özelliklerini değerlendiren sorular soruldu ve yanıtları kaydedildi. Bulgular: Çalışmaya katılan 82’si (%68,9) kadın, 37’si (%31,1) erkek 119 hastanın yaş ortalaması 54,3±1,3 yıl (19-81) olarak bulundu. Hastaların 69’u (%57,99) hekim önerisi ile Aspirin kullanımı olduğunu belirtirken 50 hasta (%42,01) hekim önerisi dışında kullanım nedeni belirtti. Hekim önerisi dışında kullanımda sadece 13 (%26) hastada Aspirin kullanımının amaca uygun olduğu belirlendi. Katılımcıların 44’ü (%37) prospektüsü okuduğunu belirtti. Hekim önerisi ile Aspirin kullanımı olan grupta hastaların hekim tarafından bilgilendirilme oranı %37,7 (26 kişi) idi. Sonuç: Bu çalışmada hekim önerisi dışında Aspirin kullanımına başvuran hastalarda endikasyon dışında veya endikasyona uygun olmayan dozlarda Aspirin kullanımının oldukça yaygın olduğu belirlenmiştir. Hastalarda hekim önerisi dışında Aspirin kullanımı konusunda farkındalık oluşturmak, risklerin azaltılması yönünde olumlu bir katkı sağlayabilir.

Copyright of Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi is the property of Istanbul Gelisim Universitesi Saglik Bilimleri Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

End-stage renal disease (ESRD) is a devastating disease associated with cardiovascular morbidity. The prevalence of pericardial syndromes associated with ESRD is increasing because the survival of chronic renal failure (CRF) patients is prolonged. Pericardial involvement in ESRD is seen commonly as acute uremic or dialysis pericarditis and infrequently as chronic constrictive pericarditis (CCP). Here, we report on a 17-year-old male patient who started hemodialysis after kidney graft loss and did not comply with the treatment, and presented with recurrent chest pain, dyspnea, and hypotension. Sequential hemodialysis treatment was given to the patient, who had recurrent pericardial effusion. Despite frequent hemodialysis treatment, the patient's response to treatment was not adequate. After diagnosis with CCP, total pericardiectomy was performed for definitive treatment. A literature review revealed end-stage kidney disease appears to be a relatively rare cause of CCP. Only a few other cases have been reported so far, mostly in adulthood. This case highlights that CRF patients presenting with symptoms of right heart failure should be investigated for constrictive pericarditis with clinical evaluations and examinations. [ABSTRACT FROM AUTHOR]

Aim:Cardiovascular diseases (CVH) still maintain their leadership among causes of death. Many studies have been carried out on risk factors and the relationship of disease and their proven recommendations have entered current guidelines. However, it is seen that there are opposing interpretations in the literature regarding the relationship between water hardness and CVH and definite conclusions are still not reached. In Çanakkale province center, drinking water needs are met from two different sources with different hardness degrees. This may help to better understand the relationship between water hardness level and CVH. The study was designed for this purpose.Materials and Methods:Patients with a diagnosis of atherosclerosis (coronary artery, carotid artery and peripheral artery disease), who applied to Çanakkale Onsekiz Mart University Training and Practice Hospital between 2015 and 2020, were retrospectively identified, and atherosclerotic group was formed. Corresponding to this group, a non-atherosclerotic (non-AS) group was formed by observing “propensity score matching” according to age, gender, arterial hypertension (HT), diabetes mellitus (DM), and presence of dyslipidemia (DL). The pH, hardness, calcium, magnesium values of the last five years were determined from the city center drinking water analyses taken from local governments and were associated with the address. Using this information, cases consuming water of different hardness were determined. Statistically, the significance of the water hardness values between the two groups was evaluated.Results:There was no significant difference in age, gender, arterial HT, DM, DL between the groups (p>0.05), and very high hardness water consumption was found significantly higher in the non-AS group (p

Copyright of MN Cardiology / MN Kardiyoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

There is a strong cause-effect relationship between Obstructive Sleep Apnoea syndrome (OSAS) and many cardiovascular diseases. A high prevalence of cardiac arrhythmia has also been reported in patients with OSAS. Nocturnal intermittent hypoxia, increased negative intrathoracic pressure and increase in sympathovagal activity are defined as the pathophysiological mechanisms by which OSAS triggers and/or increases cardiac arrhythmogenesis. Herein, in the light of a case report, we aimed to review the relationship between OSAS and cardiac arrhythmia.

Coronavirus disease 2019 (COVID-19), is caused by a novel coronavirus named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It became a major global health threat in a short time after being declared by the World Health Organization (WHO) as a pandemic on March 11, 2020. Viral, environmental, and host factors play a role in the course of COVID-19. The disease is more common in the elderly, men, and people with diabetes mellitus, hypertension, cardiovascular disease, chronic renal disease, and malignancy. While some risk scores are used to predict ICU admission and mortality, they are not specific to COVID-19. Identifying high-risk individuals and preventing their infection can reduce mortality in the disease. [ABSTRACT FROM AUTHOR]

Amaç: Bu çalışmanın amacı genç hastalarda koroner arter hastalığının (KAH) sıklığını ve risk faktörlerini değerlendirmektir.Gereç ve Yöntem: Ocak 2000 - Mart 2016 tarihleri arasında koroner anjiyografi yapılan 21514 hastanın tıbbi kayıtları tarandı. 45 yaşından büyük ve ağır kapak hastalığı olan hastalar çalışma dışı bırakıldı. Çalışmaya toplam 862 hasta dahil edildi. KAH için başlıca risk faktörleri değerlendirilmiştir.Bulgular: Çalışılan toplam 862 hastanın 595'inde KAH, 267'sinde normal koroner arter (NKA) vardı. genç KAH grubunda erkek yüzdesi (% 94,1 vs. % 58.8) ve sigara içme oranı (% 78 vs. % 45) yaşları açısından benzer olan NKA grubuna göre yüksekti. KAH hastalarında obezite oranı kadınlarda erkeklerden daha yüksek iken (% 41 vs. % 14), sigara içme oranı erkeklerde kadınlara göre daha yüksekti (% 80 vs. % 44). Çok değişkenli analizlere göre erkek cinsiyet [Olasılık Oranı (OO) = 7,3,% 95 Güvenlik aralığı (GA) 4,6-11,4] ve sigara (OO = 2,3,% 95 GA 1,6 – 3,2) KAH'ın bağımsız belirleyicileri olarak bulundu.Sonuç: Genç erişkinlerde sigara içmenin en önemli risk faktörü olduğunu gösterdik

Purpose: Biomarkers are useful measures assisting the diagnosis, treatment, and prognosis of cardiovascular diseases. They can predict the severity of cardiovascular diseases, especially in acute myocardial infarction at the emergency department. We aimed to investigate the severity of cardiovascular disease using three biomarkers, namely cardiac troponins, C-reactive protein (CRP), and procalcitonin in patients with ST-elevation myocardial infarction who presented to the emergency department. Material and Methods: The study included a total of 166 patients that presented with ST-elevation myocardial infarction (STEMI) in the first three hours of symptom onset and underwent coronary angiography. SYNTAX (SS) scores were calculated, and based on these scores, two groups were formed. High-sensitivity troponin T (Hs- TnT), high-sensitivite CRP (Hs-CRP), and procalcitonin levels were measured at the presentation. Results: Although the high sensitive troponin, Hs-CRP values were higher in the SYNTAX score>20 groups, there was no statistically significant difference between the two groups. There was no significant difference in the PCT measurements between the two groups Conclusion: When Hs-TnT and Hs-CRP are evaluated together in patients with STEMI with a high SS, it may be predictive in early determining the severity of coronary artery disease. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to evaluate the use of Aspirin and to raise awareness on the subject in patients. Materials and Methods: Patients admitted to the Family Medicine Outpatient Clinic, University of Health Sciences Antalya Training and Research Hospital, and who have used Aspirin at least once in their life were included in the study. The reasons for using Aspirin were questioned to the patients. Patients were seperated into two groups, use of Aspirin with the physicians’ recommendation and use of Aspirin without the physician's recommendation. Patients were questioned about their clinical characters and Aspirin use and their responds were recorded. Results: Of all the patients, 68,9% of them were female and %31,1 were male. The mean age was 54,3±1,3 (19-81) years. 69 (57.99%) of patients were taking Aspirin with the physicians’ recommendation and 50 (42.01%) patients were taking Aspirin without a physician's recommendation. In the group which take Aspirin without a physician's recommendation, only 13 patients (26%) were using Aspirin correctly. 44 (37%) of the patients stated that they had read the prospectus. In the group which using Aspirin with the physician's recommendation, the rate of information of patients by the physician was 37.7% (26 patients). Conclusion: Use of Aspirin, which is not suitable for the indication, is very common in patients used Aspirin without a physician's recommendation. Raising awareness on using Aspirin without a physician's recommendation can make a positive contribution to reduce the risks. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Nursing Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of MN Cardiology / MN Kardiyoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The coronavirus disease-2019 (COVID-19) has rapidly developed into a global pneumonia pandemic. SARS-CoV2 infection is occurred by attaching angiotensin converting enzyme 2 (ACE2) with spike proteins on the surface of virus. Cardiovascular diseases is most common comorbidity of COVID-19 patients and is closely related to poor prognosis. COVID-19 infection may cause a some of cardiovascular complications such as myocardit, heart failure, acute coronary syndroms, arrhythmia, cardiojenic shock. These unfavourable cardiovascular complications occur due to the direct myocardial injury by ACE2 pathway or indirect cardiac effects of SARS CoV-2. Especially, Cytokine storm that develops especially due to hyper-inflammation may be responsible for cardiac damage. More than 25% of COVID-19 infected patient have myocardial injury. Thus, COVID-19 infected patients must be followed for myocardial injury during the hospital stay. [ABSTRACT FROM AUTHOR]

Metabolic syndrome is a cluster of metabolic disorders characterized by the association of risk factors such as abdominal obesity, insulin resistance, dyslipidemia, and high blood pressure. Metabolic syndrome, that increases the risk of diabetes and cardiovascular disease, is a significant problem affecting about one in eveiy two adults in our country. Both environmental and genetic factors may play a role in the development of the syndrome. Recent studies have shown that dysbiosis in the human gut microbiota may also contribute to the pathogenesis of the metabolic diseases. In this respect, it was thought that the modulation of gut by probiotics might provide beneficial effects on the components of metabolic syndrome. The proposed mechanisms for the effects of probiotics on metabolic syndrome components include regulation of inflammatory response, reduction in oxidative stress, modulation of lipid metabolism, and control of hormone levels which play a role in appetite and glycemic control. Studies have shown that the effects of probiotics on metabolic syndrome components may vary depending on the aim of use, the probiotic strain or strains used, the initial metabolic profile of individuals, and the duration and dose of intervention. Therefore, it is necessary to give specific recommendations according to the indication instead of a general probiotic recommendation. In this review, the effects of probiotics on metabolic syndrome were reviewed by considering the components. [ABSTRACT FROM AUTHOR]

Dietary therapy is one of the most important steps of treatment in cardiovascular diseases. In dietary treatment, daily salt intake should be restricted, saturated fat consumption should be avoided, consumption of polyunsaturated fats and white meats should be increased, consumption of margarine and added sugar foods should be prohibited, and consumption of fresh vegetables and fruits should be increased. The alcohol intake and smoking should be avoided. An individualized diet with appropriate calorie content should be arranged in a way that will maintain the ideal weight and prevent overweight and obesity. The benefit of diet therapy is more effective and less costly compared with pharmacological and interventional treatment methods. [ABSTRACT FROM AUTHOR]

Anaphylaxis is a multi-systemic disease, which develops associated with the sudden expression of mast cell mediators into the systemic circulation, and can be life-threatening. The majority of cases are reactions to food, drugs, or insect stings, mediated by immunoglobulin E (IgE), and may cause a process resulting in degranulation of mast cells. Severe asthma, mastocytosis, cardiovascular disease, elevated basal serum triptase, the use of beta blockers or ACE inhibitors, exercise, acute infections and emotional stress are some of the reasons increasing the risk of anaphylaxis. As cardiac functions and respiration can halt within minutes during an anaphylaxis attack, treatment must be applied rapidly immediately after diagnosis. Adrenalin is the first and most important drug which should be given in treatment. In this review, the diagnosis and treatment of anaphylaxis are summarised in the light of current literature. [ABSTRACT FROM AUTHOR]

Copyright of Acibadem Saglik Bilimleri Dergisi is the property of Acibadem University Medical School and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi is the property of Istanbul Gelisim Universitesi Saglik Bilimleri Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Our study aimed to estimate the impact of addressing modifiable risk factors on the future burden of cardiovascular diseases (CVD) in the general population and in two high-risk populations (heterozygous familial hypercholesterolemia and secondary prevention) for Turkey. Methods: One model investigated the impact of reaching the World Health Organization (WHO) voluntary targets for tobacco use, hypertension, type 2 diabetes, obesity and physical inactivity in the general population. Another model estimated the impact of reducing LDL-cholesterol in two high-risk populations through increased access to effective treatment. Inputs for the models include disease and risk factor prevalence rates, a population forecast, baseline CVD event rates, and treatment effectiveness, primarily derived from the published literature. Direct costs to the public health care system and indirect costs from lost production are included, although the cost of programs and pharmacological interventions to reduce risk factors were not considered. Results: The value of reaching WHO risk factor reduction targets is estimated at US$9.3 billion over the next 20 years, while the value of reducing LDL-cholesterol is estimated at up to US$8.1 billion for high-risk secondary prevention patients and US$691 million for heterozygous familial hypercholesterolemia patients. Conclusion: Efforts to achieve WHO risk factor targets and further lower LDL-cholesterol through increased access to treatment for high-risk patients are projected to greatly reduce the growing clinical and economic burden of CVD in Turkey.

Tüm dünyada ve ülkemizde kardiyovasküler hastalıklardan kaynaklanan morbiditenin ve mortalitenin ciddi rakamlara ulaştığı bilinmektedir. Günümüzde, yaşam tarzı ve beslenme alışkanlıkları değişimi ile kardiyovasküler hastalıkların morbiditesi artmıştır. Diyet ile alınan bitkisel steroller/stanoller, bu olumsuz çevresel koşulları çeşitli mekanizmalar aracılığıyla değiştirebilir ve iyileştirebilir. Etki mekanizması ise enterohepatik döngü içindeki kolesterol ve lipid düzenleyici hedeflerin regülasyonudur. Bağırsak lümeninde eksojen (diyet) ve endojen kaynaklı kolesterol ile rekabet etmek, bağırsak kolesterolü emilimini azaltmak ve kolesterol sentezinde görevli genlerin ekspresyonunu değiştirmek gibi önemli etkileri vardır. Hepatik döngü içerisindeki etkinliği ile kardiyovasküler hastalıklar için risk faktörü olan total kolesterol, düşük yoğunluklu lipoprotein kolesterol ve trigliserit serum konsantrasyonlarını önemli ölçüde düşürmektedir. Bunun yanı sıra, aterosklerozun patogenezinde önemli rol oynayan plazma fibrinojen düzeylerini ve trombotik etkiye neden olan trombosit düzeylerini azaltarak aterosklerotik sürece etki etmektedir.

Obesity is an important public health problem on a global scale. Overweight and obesity increase the morbidity and mortality rates leading up to short and long-term health problems, especially cardiovascular diseases and type 2 diabetes. However, people are more interested in techniques to lose weight faster. At the same time, people are looking for ways to lose weight more quickly. Popular diets come to the forefront by people who know the aesthetic concerns of people, the weaknesses of good-looking and feeling better with less effort. In this review, it is aimed to evaluate the possible effects of popular dietary practices on short and long-term body weight and health in the light of current literature. [ABSTRACT FROM AUTHOR]

The purpose of this study is to overview studies that evaluate insomnia and heart disease risks in shift workers in the literature. A total of 12 studies of descriptive, cross-sectional, cohort, systematic review and meta-analysis, prospective cohort and relationship seeking between 2005 and 2020 were included in the evaluation. Shift workers experienced sleep disorders and imparied circadian rhythm. Due to these problems, shift workers have higher risk of cardiovascular diseases and coronary heart diseases than those who do not work in shifts. This risk increased after five years with annual exposure. In addition, it was determined that the risk of cardiovascular disease mortality is high for these employees. As a result of this systematic review, it was found that shift work was associated with insomnia and cardiovascular disease. Mortality risk of cardiovascular disease was found to be high in one third of the studies reviewed. The occupational group with the highest risk of cardiovascular disease due to shift work system was found to be health workers and factory workers. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Archives of Lung is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Venlafaxine is a serotonergic and noradrenergic antidepressant. It shares serotonergic adverse effects with selective serotonin reuptake inhibitor (SSRI) antidepressants and causes noradrenergic adverse effects in particular cardiovascular disorders. However, it does not demonstrate advantages over SSRIs regarding efficacy. Most patients with a venlafaxine overdose develop only mild symptoms. Severe toxicity has been reported for venlafaxine, with the most common symptoms being central nervous system depression, serotonin toxicity, seizure or cardiac conduction abnormalities. We present a case of venlafaxine intoxication complicated by a late increase in creatine kinase (CK) level, seizures and cardiac toxicity. As reported in the literature, venlafaxine overdose can be fatal and can lead to cardiac toxicity and death. Patients may benefit from lipid emulsion-mediated therapeutic plasma exchange for the treatment of the lethal effects of venlafaxine intoxication. A 14-year-old patient with status epilepticus, long QTc interval and elevated CK level after venlafaxine overdose was successfully treated with lipid emulsion-mediated therapeutic plasma exchange. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate the comorbidities, antiretroviral therapy (ART) switches, and drug side-effects in HIV-infected patients who were followed in the Department of Infectious Diseases and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University. Methods: This study was designed as a retrospective cohort study. Files of HIV-infected patients admitted to the outpatient clinic between years 2002 and 2018 were evaluated. Among them, 210 patients over 18 years of age, whose HIV/AIDS diagnosis was confirmed with ELISA and Western Blot test, without loss to follow up longer than six months, and using ART for at least 6 months were included in the study. Their demographic and clinical features, laboratory results, initial ART regimen, and its side-effects, reasons for ART switches, and subsequent ART regimen were recorded. Results: 165 (78.5%) out of 210 patients were men, and 45 (21.4%) patients were women. Mean age of the patients was 40.4±12.373. 152 (72.4%) patients identified themselves as heterosexual, and 39 (18.6%) were men who had sex with men. Comorbidities of patients during their follow-up were hyperlipidemia in 42 (20%), hypertension in 22 (10.4%), cardiovascular disease in 13 (6.1%), type 2 diabetes mellitus in 12 (5.7%), renal dysfunction in 9 (3.8%), osteopenia/osteoporosis in 8 (3.8%) patients. Although two most common regimens in the first step therapy were tenofovir disoproxil fumarate/emtricitabine + lopinavir/ritonavir, and tenofovir disoproxil fumarate/ emtricitabine + elvitegravir/cobisistate, the second step therapy was detected as an interchange in the order of these two regimens. ART switch was detected in 71 (33.8%) patients. Leading reasons of ART switch were intolerance/toxicity in 22 (30.9%) patients, and simplification of regimen in 19 (26.7%) patients. Frequency of disorders developed after ART were 5 (2.3%) diabetes mellitus, 4 (1.9%) renal diseases, 5 (2.3%) cardiovascular events, 4 (1.9%) osteopenia, and 4 (1.9%) osteoporosis. Conclusions: HIV infection is controlled with ART and life expectancy is prolonged. Patients must be evaluated carefully for metabolic risk factors in the beginning of the treatment and treatment regimen should be selected by considering these situations. The side-effects such as hyperlipidemia, diabetes mellitus, cardiovascular diseases, bone metabolic disorders, osteopenia ve osteoporosis may also develop during the treatment. Therefore, patients must be closely monitored for the possible side-effects, and physicians must work in cooperation with the related specialties, and ART switch must be performed when required. Klimik Dergisi 2020; 33(3): 241-7. [ABSTRACT FROM AUTHOR]

Introduction: Compared to the general population, cardiovascular diseases are more common in schizophrenia patients and the mortality rate is higher than the general population. One of the explanations for increased cardiovascular events in patients with schizophrenia is the increase in platelet activity. Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombus formation. Mean platelet volume (MPV) is a measure of platelet size and a good marker of platelet function and activation, which increases in cardiovascular diseases. MPV is routinely reported during complete blood count analysis. The aim of the present study was to evaluate MPV values of patients with schizophrenia. Methods: In this retrospective study, hospital-records of the patients who were consecutively admitted to psychiatry inpatient clinic between January 2015 and January 2017 with the diagnosis of schizophrenia were reviewed. Healthy subjects with no personal history of psychiatric disorder were included as a control group. Results: A total of 100 (59 female, 41 male) schizophrenic patients who had been consecutively admitted to the psychiatry inpatient clinic and 37 (20 female, 17 male) healthy controls were included in this retrospective study. There were no significant differences between the patient group and control group in the terms of age (mean age patient group vs control group: 37.72 vs 35.03, p=0.081) and sex (p=0.603). Body mass index (BMI) was found to be significantly different between groups, higher in the patient group (p=0.001). The MPV was found to be significantly higher in patient group compared with the control group (MPV, patient group vs control group: 10.34 fL vs 9.97 fL, p=0.041). Platelet count (PC) was significantly lower in the patient group (PC, patient group vs control group: 234.36 vs 267.38, p=0.008) There was no correlation between MPV and BMI (p=0.354, r=0.10), and duration of illness (p=0.530, r=0.06). Conclusions: As a result, increased MPV and decreased PC were found in a group of schizophrenic patient in this study. Since increased MPV and decreased PC are evaluated as risk factors for cardiovascular diseases in the general population, they can also be considered as a predictor of risk factors for cardiovascular diseases that are more frequently encountered in schizophrenia.

hPON1 is an ester hydrolase associated with HDL and having a molecular mass of 43-45 kDa. It is synthesized in the liver. It hydrolyzes organophosphate agents and nerve gases. It plays a protective role against oxidation of LDL and formation of lipid peroxides and bacterial endotoxins. The fact that oxidation of LDL constitutes the initial stage of the atherosclerosis process demonstrates the importance of hPON1 antioxidant properties. Many epidemiological studies have shown an inverse relationship between HDL cholesterol levels and cardiovascular events. It is known that high serum HDL-cholesterol and low LDL-cholesterol levels are protective against the development of coronary heart disease and atherosclerosis. Therefore, hPON1 is a component of HDL, thus contributing to the protective role of HDL in coronary artery disease. In this research, we investigated the inhibition effects of bendamustine on hPON1 enzyme activity in the human serum in vitro conditions. [ABSTRACT FROM AUTHOR]

Background: The Model for End-stage Liver Disease excluding the international normalised ratio (INR, MELDXI) and modified MELD, which uses albumin in place of the INR (MELD-Albumin) scores reflect liver and renal function and are predictors of mortality. Although MELD score has been studied in patients with ST-segment elevation myocardial infarction (STEMI), prognostic value of MELD-XI and MELD-Albumin scores has not been studied in those patients. Our aim was to determine the predictive value of MELD-XI and MELD-Albumin scores on mortality in patients with STEMI. Materials and Methods: 1506 consecutive STEMI patients who applied to the emergency department and underwent primary percutaneous coronary intervention (PPCI) were evaluated retrospectively. The parameters evaluated for prognosis were primarily mortality and other major cardiac events (MACE) at in-hospital and 12- month follow-up. Patients were stratified into 5 groups according to MELD-Albumin score. Results: The patients with higher MELD-Albumin and MELD-XI scores had significantly higher in-hospital and long-term mortality. The multiple logistic regression analysis identified the MELD-XI and MELD-Albumin scores as the independent predictors of in-hospital and 12-month mortality. ROC curve analysis showed that area under curve (AUC)s of MELD-Albumin were higher than than MELD-XI AUCs for predicting mortality both in-hospital and at 12-month follow-up. Conclusions: The MELD-Albumin score is an easily calculable, reliable, and practical risk assessment tool. This score may be used as an independent predictor of in-hospital and long-term mortality in patients with STEMI. [ABSTRACT FROM AUTHOR]