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Background and Design: Primary cutaneous B-cell lymphomas (PCBCLs) have not been well characterized due to their relatively low incidence and heterogeneous clinical features. Materials and Methods: Data of 29 patients with primary cutaneous marginal zone lymphoma (PCMZL) (n=18), primary cutaneous follicle center B-cell lymphoma (PCFCL) (n=7), and primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT) (n=4) who were followed and treated at Ankara University Faculty of Medicine between 2006 and 2022 were retrospectively evaluated. Clinical characteristics, treatment modalities, and outcomes of all patients were analyzed. Results: Our study supports the data that there are geographical differences in the distribution of B-cell lymphomas and that PCMZL is predominant in Asian countries compared to Europe. The mean age at the time of diagnosis in the PCDLBCL-LT group was significantly older than the indolent PCBCL group (p=0.022). The lesion size was predominantly less than 2 cm in PCMZL, between 2 and 5 cm in PCFCL, and larger than 5 cm in the PCDLBCL-LT group (p=0.006). While skin-directed treatments were the most common approach in the PCMZL and PCFCL groups, multi-agent chemotherapy was the preferred treatment in the PCDLBCL-LT group (p=0.003 and p=0.001, respectively). No significant correlation was found between age, gender, clinical features of the lesion, cutaneous lymphoma international prognostic index score, stage and treatment modalities, recurrence, and overall survival. The World Health Organization and European Organization for Research and Treatment of Cancer classification of cutaneous lymphoma remains the primary guideline for understanding the clinical behavior and prognostic parameters of this heterogeneous patient group. Conclusion: Given the relative rarity of these types of lymphoma, our patient collective provides an additional value to the existing literature.

Cutaneous leiomyosarcoma (CLMS), with an annual incidence of 0.2/100,000, is a very rare non-melanoma skin malignancy. CLMS has two subtypes: Dermal (primary) and subcutaneous; when diagnosed in the early period, the prognosis in the dermal type is better. CLMS is generally seen in the 6th and 7th decades of life and more frequently in the lower extremities and head and neck. Trauma, radiation, chemicals, and sun rays have been reported as the factors involved in its etiology. Epidermal cysts, skin metastases, dermatofibrosarcoma pro-tuberans, and keloid should be considered in the differential diagnosis of CLMS, which usually manifests as a nodular lesion. In the presented case, the lesion, which developed over scar tissue was diagnosed as keloid and treated accordingly for four years. The pathologic examination of dermal CLMS (d-CLMS) in this patient, in whom diagnosis was delayed, revealed invasion of the subcutaneous fat tissue, which is among the poor prognostic factors. Herein, we present a case with d-CLMS, in which early recognition is vitally important, who was treated for an extended period as keloid, and we emphasize the differential diagnosis in CLMS and pathological and dermatoscopic features that, to our knowledge, are being reported here for the first time.

Between 2015 and 2018, a clear increase was noticed in the cases of onychomycosis in which species of Aspergillus were cited as the cause while stimulating studies have been conducted. With this case, we call attention to the increasing frequency of Aspergillus niger onychomycosis in recent years and highlight the options for diagnosis and treatment as well as the risk factors and clinical and pathological properties of the disease.

The pathogenesis of mycosis fungoides (MF) is poorly understood, and an immunogenetic mechanism has been suggested to play a role. Human leukocyte antigen (HLA) class II alleles DRB1*11 and DQB1*03 were found to be significantly increased for patients with sporadic and/ or familial MF. The juvenile-onset familial MF is extremely rare. Herein, we report two siblings diagnosed with folliculotropic MF, both exhibiting similar morphology of a unilesional presentation on the flexural region of the arms. Both were positive for HLA-DRB1*04 and HLA-DQB1*03 alleles. The HLA-DQB1*03 allele has been described in familial MF in the literature recently, whereas “HLA-DRB1*04” allele has not been reported previously in familial MF cases.

29-year-old woman presented with dark-colored raised lesions on both eyelids since early childhood. Ophthalmological examination revealed pigmented verrucous lesions on her upper and lower eyelids bilaterally. The patient had a history of generalized tonic-clonic seizures. Dermatological examination revealed hyperpigmented verrucous plaques arranged along lines of Blaschko on the neck, trunk, and arms. On the basis of these findings, the diagnosis of epidermal nevus syndrome (ENS) was made. She had surgery for debulking of the lesions. Histological analysis revealed hyperkeratosis with foci of parakeratosis, acanthosis, and papillomatosis, consistent with linear verrucous epidermal nevus. Postoperative residual lesions did not respond to oral acitretin therapy (10 mg/kg/day for 2 months). Systematized ENS can rarely cause linear verrucous nevi on the upper and lower eyelids on both sides. These patients should be investigated for accompanying systemic anomalies and followed for potential malignant transformation of the skin lesions.

Pur po se: To evaluate the clinical and histopathological features of benign eyelid tumors. Ma te ri al and Met hod: We retrospectively evaluated the records of the patients who have been operated for benign eyelid tumors at the Ophthalmology Department of Ankara University, Faculty of Medicine, between January 2009 and May 2010. Anterior segment photography was performed in all patients and correlated with histopathological results. Re sults: Of 79 cases, 43 (54%) were males and 36 (46%) were females. Mean age of the patients was 53 years (range: 10-82 years). Benign eyelid tumors were most commonly seen in the sixth decade of life (29%). Histopathological diagnoses of benign eyelid tumors were as follows: nevus (15 patients, 19%), papilloma (15 patients, 19%), seborrheic keratosis (11 patients, 14%), inflammatory lesions (10 patients, 13%), epidermal inclusion cyst (8 patients, 10%) and sudoriferous cyst (6 patients, 7%). Cutaneous nevi were most commonly seen in the seventh decade (40%), mean age was 51 years and 67% of patients were women. Papillomas were most commonly seen in the sixth decade (40%), mean age was 50 years and 53% of patients were women. Seborrheic keratoses were most commonly seen in the seventh decade (36%), mean age was 58 years and 82% of patients were men. Inflammatory lesions were most commonly seen in the sixth decade (50%), mean age was 59 years and male to female ratio was equal. Dis cus si on: Nevi and papillomas were the most common benign tumors of the eyelids. These were followed by seborrheic keratoses and inflammatory lesions. More than 50% of benign eyelid tumors are seen between the ages of 50 and 70. In this series of patients, nevi were more commonly encountered in women, whereas seborrheic keratoses were more common in men. (Turk J Ophthalmol 2012; 42: 43-6)