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Steady, laminar natural convection flow of water-based nanofluids in an inclined square enclosure where adjacent walls heated differently, while other walls are adiabatic is investigated numerically in this study. The governing equations based Boussinesq approach are solved numerically using the polynomial differential quadrature (PDQ) method. In calculations, Rayleigh number is chosen as 104 - 106, inclination angle 0°≤φ≤120° Where values in the interval of 0≤ϕ≤0.20 for volume fraction of solid particles are considered. Rate of liquid layer thickness to radius of original solid particle is 0.1. Three types of nanoparticles, Cu, Ag, Al2O3 are taken into consideration. The results show that the Rayleigh number, inclined angle and solid volume fraction has significant effects on flow and heat transfer. As the nanoparticle volume fraction is increased, heat transfer enhances considerable amount. With an increase in the Rayleigh number, convection intensity increases, and therefore, heat transfer shows an increasing trend. Inclined angle of enclosure also affects heat transfer quantity significantly. [ABSTRACT FROM AUTHOR]