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Despite numerous studies examining the validity of Florida's creative class approach in the field of urban and regional development, no research on the entrepreneurial part of this theory has been conducted in Turkey. In this context, this study analyzes the entrepreneurial potential of the creative class working as R&D employees in technoparks and industrial park in Turkey. The study focuses on the creative class's demographic characteristics, human capital capabilities, and spatial featues as entrepreneurial tendencies. Using a mixed research method, a survey was conducted with 1352 R&D employees operating in 14 major provinces of Turkey and 255 R&D employees were interviewed simultaneously. The data obtained were analyzed using MAXQDA and SPSS software. The findings show that R&D employees define entrepreneurship primarily in terms of personal traits and effort; their perception of entrepreneurship and entrepreneurial experience influence whether they regard themselves as capable of becoming entrepreneurs in the future. Participants who have prior entrepreneurial experience and receive government support have a more optimistic attitude toward becoming an entrepreneur in the future. Additionally, it is evident that the characteristics of the cities and business regions where the creative class lives and works have an impact on entrepreneurship and that these locations enhance the entrepreneurial potential of R&D professionals. Based on R&D employees' experience, opportunity, human capital, and personality traits, the final results reveal that there is a creative class with a very high potential to be entrepreneurs in the future. This conclusion indicates that R&D employee entrepreneurship, which has a high potential for the Turkish entrepreneurship ecosystem, should be promoted primarily through public policies and practices. [ABSTRACT FROM AUTHOR]