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Multiple births and related complications have increased with the widespread use of assisted reproductive techniques (ART) in recent years. The aim of this multicenter study of the Turkish Neonatal Society was to evaluate the effects of ART on neonatal morbidity and mortality in Turkey. Between February-December 2006, data from 18 different centers were prospectively collected and analyzed. Of the 6356 newborns recruited in this study, 793 infants (12.5%) were conceived with ART. Eighty-seven percent of the study population was singleton, 10.9% was twin and 1.4% was triplet. Sixty-two percent of the multiples were conceived with ART. Prematurity, multiple births and very low birth weight were more frequent in the ART group. The frequencies of neonatal intensive care unit (NICU) admissions and surfactant and mechanical ventilation along with morbidities such as intraventricular hemorrhage, patent ductus arteriosus, sepsis, and mortality were higher in ART infants. ART-induced pregnancies carry higher risks of neonatal morbidity and mortality. Couples considering ART should be informed about the possible maternal and neonatal risks of ART and multiple gestations. [ABSTRACT FROM AUTHOR]