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Background: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a difference between oxidative stress status in patients with intestinal metaplasia (IM) compared to individuals without IM, we compared the serum levels of disulfide (SS), total thiol (TT) and native thiol (NT). Methods: This was a prospective, non-randomized casecontrol study including 67 patients with histopathologically confirmed IM and 60 individuals demographically matched in terms of age, gender, BMI, smoking status, and chronic diseases as control group. Results: The mean NT, TT and NT to TT (NT/TT) ratios were statistically significantly higher in IM group compared to controls ((351.71 ± 81.9 _mol/L vs. 271.82 ± 54.13 _mol/L, p=0.000), (391.5 ± 92.69 _mol/L vs. 308.59 ± 55.53 _mol/L, p=0.000) and (0.89 ± 0.6 vs. 0.87 ± 0.29, p=0.022), respectively). The mean SS to TT (SS/TT) ratio was significantly lower in IM group than control group (0.050 ± 0.31 vs. 0.060 ± 0.014, P=0.022). Median SS and mean SS/NT ratio was similar in both groups (16.3 (3.3-78) vs. 18.3 (10-32.7), p=0.271 and 0.055 ± 0.041 vs. 0.070 ± 0.019, p=0.068, respectively). In ROC analysis, cut off value of SS/NT for IM was found 0.062, in regression analysis, SS/NT

Aim: Myelodysplastic syndromes (MDS) include a group of hematological malignancies characterized by clonal hematopoiesis, one or more cytopenias (anaemia, neutropenia, and/or thrombocytopenia), and abnormal cellular maturation. The incidence of this disease group increases with increasing age, and physicians should have knowledge about it. MDS is one of the interesting topics in the field of hematology. This article, which evaluates the publications on this subject in our country and in the world with bibliometric evaluation, aims to give direction to those who work and will work on this subject.Material and Method: Scopus bibliometric database was scanned. Original research articles, which include the keywords “myelodysplastic syndrome” and “Article” in the title, abstract and keywords, were reached between 1954-2021. Publications were elevuated due to their institution, author, publication year, subject, number of citations and published journal.Results: It was determined that there were 33,518 publications on MDS and the first publication was published in the year 1954. 22,033 of these publications were original research papers. The United States (USA) (n=6998, 31.8%) was the most scientifically productive country in this regard. The three leading institutions with the most articles on this subject are; University of Texas Dr Anderson Cancer Center (4.7%), Fred Hutchinson Cancer Research Center (2.2%), and Dana-Farber Cancer Institute (2.1%). 1297 of the articles on MDS were cited at least 100 times. The most cited article received 4574 citations. Our country was in 19th place and 328 articles were published. After the year 2000, there was a rapid increase in the number of publications and the highest number of publications (28 articles) was published in 2020. The highest number of articles (17 articles) from our country was published in the Turkish Journal of Hematology.Conclusion: It is understood that the studies originating from Turkey should be increased numerically and should be placed higher in the ranking., Amaç: Miyelodisplastik sendrom (MDS) hematoloji alanının ilgi çeken konu başlıklarındandır. Bu çalışmada, MDS hakkındaki bilimsel litetarürün gözden geçirilmesini amaçladık. Yöntem: Scopus bibliyometrik veri tabanında İngilizce dilinde tarama yapıldı. Başlık, özet ve anahtar kelimelerinde "myelodysplastic syndrome" ve "Article" anahtar kelimeleri içeren, 1954-2021 yılları arasında yapılmış orijinal araştırma makalelerine ulaşıldı. Yayınlar; yapıldıkları kurum, yazar, yayın yılı, konu, atıf sayısı ve yayınlandıkları dergi açısından değerlendirildi.Sonuçlar: Bu konuda; 33.518 yayın olduğu, ilk yayının 1954 yılında yayınlandığı saptandı. Bunların 22.033 tanesi orijinal araştırma makalesi idi. Amerika Birleşik Devletleri (ABD)(n=6998,%31,8) bu konudaki en bilimsel üretken ülke idi. Bu konuda en fazla makalesi bulunan 3 öncü kurum; Texas Üniversitesi Dr Anderson Kanser Merkezi (%4,7), Fred Hutchinson Kanser Araştırma Merkezi (%2,2) ve Dana-Farber Kanser Enstitüsü (%2,1) idi. MDS konulu makalelerin 1297’si en az 100 kez atıf almıştı. En fazla atıfı alan makale 4574 atıf almıştı. Ülkemiz 19. sırada yer almakta olup, 328 makale yayınlanmış idi. 2000 yılından sonra yayın sayısında hızlı bir artış olmuş ve en fazla yayın (28 makale) 2020 yılında yayınlanmıştı. Ülkemizden en fazla sayıda makale (17 makale) Turkish Journal of Hematology’de yayınlanmıştı.Tartışma: Analiz çalışmamız MDS hakkında yapılan yayınların atıf sayılarının oldukça yüksek olduğu yönünde idi. Bu da araştırmacıları bu konuda yayın yapmaya teşvik edebilir. Ayrıca ülkemizden bu konuda yapılması gereken yayın sayılarının arttırılması gerekmektedir.