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Objective: Although the tenofovir alafenamide/emtricitabine/bictegravir (TAF/FTC/BIC) regimen is recommended in national and international guidelines for changing treatment in treatment-experienced patients living with HIV (PLwHIV), there are limited real-life data reported in Türkiye. We aimed to evaluate the changes in virological and immunological indicators, renal functions, and lipid profiles in the follow-up of patients who switched to TAF/FTC/BIC. Methods: The study included treatment-experienced PLwHIV aged 18 years or older who were followed at the infectious diseases outpatient clinic between January 2020 and December 2021. Follow-up parameters before and after switching to TAF/FTC/BIC were evaluated retrospectively. Results: A total of 77 PLwHIV were included. Of those, 71 (92.2%) were male, and the median age was 42 years. The 24th and 48th week median HIV RNA values of patients whose viral loads were measured were 35 (27-77) copies/ml and 34 (24-49) copies/ml, respectively, after switching. We did not detected a significant difference in CD4+T lymphocyte count, CD4+ T lymphocyte percentage, and CD4+/CD8+ ratio when compared with pre-treatment values. Virological suppression was not maintained in 24.7% (n=19/77) of PLwHIV. While "incomplete virological response" was not detected in any patients, 2.6% (n=2/77) had virological rebound, 1.3% (n=1/77) were virological non-responders, 10.4% (n=8/77) had low-level viremia, and 20.8% (n=16/77) had virological blip. Glomerular filtration rate (GFR) (101 ml/min./1.73m² vs. 96 ml/min./1.73m², p=0.05) and total cholesterol level (199 mg/dl vs. 185 mg/dl, p=0.05) decreased at 48th week. In switching from tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat (TAF/FTC/EVG/Cob) to TAF/FTC/BIC, significant decreases were detected in GFR (101 ml/min./1.73m² vs. 95 ml/min./1.73m², p=0.016) and total cholesterol levels (205 mg/dl vs. 182 mg/dl, p<0.001). Conclusion: Even if virological suppression is achieved before switching, virological suppression may be impaired in patients after switching to TAF/FTC/BIC. Moreover, renal functions should be closely monitored due to the significant decrease in GFR, especially when switching from TAF/FTC/EVG/Cob to TAF/FTC/BIC. [ABSTRACT FROM AUTHOR]

This study aims to investigate the development extracts of Cistus creticus which is among medicinal and aromatic plants loaded with controlled delivery solid lipid nanoparticle systems and to investigate the antimicrobial activity of these systems against pathogen test microorganisms. Within the scope of this study, ethanol and water extracts from Cistus creticus leaves were obtained by using the ultrasonic method. The characterization of plant extracts loaded with solid lipid nanoparticles was evaluated by SEM, DLS analyses, and zeta potentials, in vitro release profiles. The sizes of ethanol and water plant extracts loaded solid lipid nanoparticles are respectively 40-90 nm, zeta potentials -35.5 and -30.7 mV and PDI values 0.455 and 0.475 were determined. The MIC values of the obtained solid lipid nanoparticles on pathogenic test microorganisms (Listeria monocytogenes ATCC 19115, Staphylococcus aureus ATCC 25923, Klebsiella pneumoniae NRRLB 4420. Pseudomonas aeruginosa ATCC 27853, Enterococcus faecalis ATCC 51289, Escherichia coli ATCC 35218, Escherichia coli ATCC 25922) were determined as in the range of 56-25 mg/mL. According to the results of the good diffusion test, microorganisms were determined as susceptible, moderately sensitive, and resistant to the extract-loaded solid lipid nanoparticles. The highest antimicrobial effect was determined against L. monocytogenes ATCC 19115 with a zone diameter of 19±0.75 for ethanol extract-loaded nanoparticles. [ABSTRACT FROM AUTHOR]

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Background: To compare the lipid profile of preeclamptic pregnant women with the lipid profile of normal pregnant women. Materials and Methods: This study consisted of 40 severe preeclamptic, 40 mild preeclamptic, and 40 healthy pregnant patients who were prospectively admitted to the hospital in Harran University Faculty of Medicine, Department of Obstetrics and Gynecology between June 2021 and June 2022. Age, pregnancy and delivery numbers, blood pressure and pulse values, Body Mass Index (BMI), blood total cholesterol, LDL, HDL triglyceride (TG) levels and hemogram parameters (Hemoglobin, Hematocrit, WBC, Platelet count and MPV) of all patients were evaluated.he study was planned as descriptive cross-sectional. The attitudes of the students studying at the Faculty of medicine towards scientific research were questioned. In the study, the "Attitude Scale Towards Scientific Research" was used. Results: A statistically significant difference was found between systolic - diastolic blood pressures and heart rate values according to the groups (p<0.001 for all groups). It was found that the BMI of the pregnant women in the preeclampsia (PE) groups was higher than the control group and there was a significant difference between the BMIs according to the groups (p<0.001). It was determined that total cholesterol, TG and LDL values of pregnant women with preeclampsia were higher than healthy pregnant women, and HDL values were lower than healthy pregnant women (p<0.001). Conclusions: In this study, it was observed that the lipid profile in PE patients was higher than the lipid profile in normal pregnant women, and preeclamptic pregnant women were more obese. It was concluded that pregnant women with preeclampsia are a risky group in terms of lipid profile and should be followed up in the postpartum period. [ABSTRACT FROM AUTHOR]

Background: Acute coronary syndromes (ACS) which is consist of ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris (USAP) are a group of diseases with acute vascular occlusion. In this article, we aimed to investigate the relationship between ACS types and multivessel disease in patients who underwent coronary angiography. Materials and Methods: A total of 2048 patients with ACS who underwent coronary angiography between July 2019 and September 2022 were included in the study. Demographic characteristics, lipid profile and angiography reports of the patients were examined, as well as epicrisis. Lipid profiles and the number of vessels with critical stenosis-were recorded by forming 3 groups as STEMI, NSTEMI and USAP. Results: 522 (25.4%) STEMI, 1116 (54.5%) NSTEMI and 410 (24.1%) USAP patients were included in the study. The STEMI group was younger than the NSTEMI and USAP group (p<0.001 and p=0.043, respectively), had a higher smoking rate (p=0.043 and p=0.027, respectively), had higher LDL-C values (p=0.040 and p<0.001, respectively). Three or more vessel disease was detected most in the STEMI group compared to the NSTEMI and USAP group (p<0.001, for all). There was a weak but positive significant correlation between LDL-C and HbA1c values and the number of vessels with coronary occlusion-stenosis (r:0.163, p<0.001; r:0.349, p<0.001, respectively). there was also negative correlation with HDL-C (r:-111, p=0.001). Conclusions: Multiple vessel disease was found to be more common in ACS patients presenting with STEMI. [ABSTRACT FROM AUTHOR]

In view of the high sequence homology of the ATP binding sites between the lipid kinase phosphoinositide 3-kinase (PI3K) isoforms, selective inhibitors of PI3Kγ have been developed. In this study, R-group enumeration library screening was performed to increase the binding affinity of the known selective inhibitor to the PI3Kγ enzyme. Virtual screening was performed using Glide SP/XP docking protocols. The interactions between the molecules identified by screening and the PI3Kγ protein were examined. In addition, ADME analyzes of these molecules were performed and hit molecules (3, 4) were determined. It was determined by in silico approaches that these hit molecules could be potential PI3Kγ inhibitors. In addition, these hit molecules can be used as lead to design other molecules targeting the PI3Kγ protein. [ABSTRACT FROM AUTHOR]

Copyright of Fenerbahce University Journal of Health Sciences (FBU-JOSH) / Fenerbahçe Üniversitesi Sağlık Bilimleri Dergisi is the property of Fenerbahce University Journal of Health Sciences (FBU-JOSH) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Health (2602-2834) is the property of Scientific Web Journals (SWJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)