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Your search keyword '"M Heilig"' showing total 19 results
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19 results on '"M Heilig"'

3. [Opioid prescription changes in Sweden 2000–2015].

Author

Bäckryd E, Heilig M, and Hoffmann M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Dextropropoxyphene administration & dosage, Female, Humans, Male, Middle Aged, Morphine administration & dosage, Oxycodone administration & dosage, Pain drug therapy, Sweden, Tramadol administration & dosage, Young Adult, Analgesics, Opioid administration & dosage, Drug Prescriptions statistics & numerical data, Practice Patterns, Physicians' trends
Abstract

Opioid prescription changes in Sweden 2000-2015 In contrast to the well-established »opioid epidemic« in the US, very little is known about how the prescription of opioids in Sweden has developed during the last decade. Aggregated data from the open Statistical database of the Swedish Board of Health and Welfare were analyzed descriptively. The yearly prevalence of opioid prescription did not change 2006-2015, but there were dramatic shifts in the choice of opioids. During this period, dextropropoxyphene was pulled off the market. Tramadol was used by fewer individuals (-54 % over the decade), but dosages expressed as Defined Daily Dose/patient/year (DDD/pat/y) increased (+41 %). In contrast, oxycodone and morphine were used by more individuals (+465 % and +137 %, respectively), but DDD/pat/y decreased during the period (-56% and -54%). Studies on non-aggregated data from available registries are needed to further elucidate the circumstances and possible consequences of these shifts in opioid prescription patterns.

Published
2017

5. [New guidelines against unfair treatment of narcotic addicts necessary].

Author

Heilig M and Gunne L

Subjects
Buprenorphine administration & dosage, Health Policy, Humans, Methadone administration & dosage, Narcotics administration & dosage, Outcome Assessment, Health Care, Practice Guidelines as Topic, Sweden, Drug Users, Opioid-Related Disorders rehabilitation, Patient Rights
Published
2008

6. [Reduced drug craving and better social function with buprenorphine therapy. Combination therapy as an alternative to methadone therapy in heroin addiction].

Author

Heilig M and Kakko J

Subjects
Drug Therapy, Combination, Heroin Dependence psychology, Heroin Dependence rehabilitation, Humans, Socioeconomic Factors, Sweden, Buprenorphine administration & dosage, Heroin Dependence drug therapy, Methadone administration & dosage, Narcotic Antagonists administration & dosage, Narcotics administration & dosage
Published
2003

7. [Ecstasy is a dangerous drug the society chooses to ignore].

Author

Heilig M

Subjects
Animals, Brain drug effects, Brain pathology, Hallucinogens administration & dosage, Humans, N-Methyl-3,4-methylenedioxyamphetamine administration & dosage, Nerve Degeneration chemically induced, Neurons drug effects, Receptors, Dopamine drug effects, Serotonin Agents administration & dosage, Hallucinogens adverse effects, N-Methyl-3,4-methylenedioxyamphetamine adverse effects, Serotonin Agents adverse effects
Published
2003

8. [Researchers and psychiatrists defending Gillberg's research on ADDH: Karfve's campaign is a form of personal persecution and scientific basis is missing].

Author

Adolfsson R, Bejerot S, Engel J, Forssberg H, Heilig M, Humble M, Ingvar M, Levander S, Oreland L, Pedersen N, Asberg M, and Ohman A

Subjects
Adult, Child, Confidentiality legislation & jurisprudence, Humans, Patient Rights legislation & jurisprudence, Scientific Misconduct, Sweden, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity therapy, Peer Review, Research, Research Support as Topic
Published
2003

9. [The brain behind stress and fatigue depression].

Author

Heilig M, Oreland L, Ekman R, Akerstedt T, and Nygren A

Subjects
Brain metabolism, Brain physiopathology, Burnout, Professional etiology, Burnout, Professional genetics, Burnout, Professional metabolism, Burnout, Professional physiopathology, Genetic Predisposition to Disease, Humans, Physicians psychology, Brain physiology, Depression etiology, Depression genetics, Depression metabolism, Depression physiopathology, Fatigue Syndrome, Chronic etiology, Fatigue Syndrome, Chronic genetics, Fatigue Syndrome, Chronic metabolism, Fatigue Syndrome, Chronic physiopathology, Mental Fatigue etiology, Mental Fatigue genetics, Mental Fatigue metabolism, Mental Fatigue physiopathology, Stress, Psychological complications, Stress, Psychological genetics, Stress, Psychological metabolism, Stress, Psychological physiopathology
Published
2002

10. [Documented effect of methadone, but not naltrexone].

Author

Heilig M

Subjects
Heroin Dependence rehabilitation, Humans, Treatment Outcome, Methadone administration & dosage, Naltrexone administration & dosage, Narcotic Antagonists administration & dosage, Narcotics administration & dosage, Opioid-Related Disorders rehabilitation
Published
2002

14. [Re-establishing the medical culture in psychiatry!].

Author

Heilig M

Subjects
Clinical Competence, Humans, Medicine, Mental Disorders diagnosis, Mental Disorders etiology, Mental Disorders therapy, Mental Health Services, Research, Specialization, Psychiatry
Published
1999

15. [Substance dependence is easier to prevent than to treat. But is early identification of individuals at risk and aimed prevention ethically justified?].

Author

Heilig M

Subjects
Alcoholism diagnosis, Alcoholism prevention & control, Alcoholism psychology, Alcoholism therapy, Brain Mapping, Concept Formation, Humans, Substance Withdrawal Syndrome diagnosis, Substance-Related Disorders diagnosis, Substance-Related Disorders psychology, Substance-Related Disorders therapy, Substance-Related Disorders prevention & control
Published
1999

16. [Antisense oligonucleotides are clinically tested. They inhibit the expression of disease-related genes].

Author

Sommer W and Heilig M

Subjects
Cell Transformation, Neoplastic drug effects, Clinical Trials as Topic, DNA drug effects, Gene Expression genetics, Humans, Inflammation drug therapy, Inflammation genetics, Neoplasms drug therapy, Neoplasms genetics, Oligonucleotides, Antisense therapeutic use, RNA, Messenger drug effects, Virus Diseases drug therapy, Virus Diseases genetics, Gene Expression drug effects, Genetic Therapy methods, Oligonucleotides, Antisense pharmacology
Abstract

Recent advances in molecular biology have improved our understanding of basic pathophysiological mechanisms, and indicated possible strategies for their manipulation. The use of oligonucleotides occupies a prominent position among the emerging strategies, and has given rise to a new generation of pharmaceutical preparations now entering clinical usage. Antisense oligonucleotides are capable of blocking the expression of specific genes, thus permitting highly precise intervention in pathophysiology at the molecular level. Several clinical trials have recently produced highly promising results. The most likely applications of antisense agents are viral infections, malignancies, and chronic inflammatory disease. The article consists in a presentation of the antisense principle, discussion of its advantages and limitations, and a review of recent clinical developments and future prospects.

Published
1999

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