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Your search keyword '"Ingelsson, Martin"' showing total 3 results
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3 results on '"Ingelsson, Martin"'

1. [Alzheimer's disease - the most common cause of dementia].

Author

Bogdanovic N, Hansson O, Zetterberg H, Basun H, Ingelsson M, Lannfelt L, and Blennow K

Subjects
Amyloid beta-Peptides, Biomarkers, Humans, Quality of Life, Sweden, tau Proteins, Alzheimer Disease complications, Alzheimer Disease genetics, Dementia etiology
Abstract

Alzheimer's disease is the most common cause of dementia. As many as 250,000 people in Sweden will have a dementia disease in 2050. The »amyloid cascade hypothesis« is a common model which explains how β-amyloid affects the function of the nerve cells. Alzheimer's disease has a long-lasting course and can present in typical and atypical forms. CSF analyses for »core AD CSF biomarkers« and synaptic proteins have been available for clinical diagnostics. PET scanning can detect either β-amyloid or tau aggregates in the brain of living humans. Current Alzheimer's disease therapy is based on two classes of cognition-enhancing drugs: acetylcholinesterase inhibitor and NMDA-receptor antagonist, which delays cognitive decline in most patients. The latest clinical development of potential therapy for Alzheimer's is active or passive immunotherapy against brain β-amyloid and tau, where several studies have shown varying but promising treatment effects. Non-pharmacological interventions in patients with AD aim to delay the loss of mental abilities, helping people to be independent in everyday life for as long as possible, and to increase their well-being and quality of life.

Published
2020

2. [Rare mutations aim toward future treatment].

Author

Ingelsson M, Basun H, Pettersson FE, Kilander L, Nilsson LN, and Lannfelt L

Subjects
Alzheimer Disease drug therapy, Alzheimer Disease prevention & control, Alzheimer Vaccines administration & dosage, Amyloid beta-Protein Precursor metabolism, Biomedical Research, Brain metabolism, Genetic Predisposition to Disease, Humans, Immunization, Passive, Immunotherapy, Mutation, Risk Factors, tau Proteins metabolism, Alzheimer Disease genetics
Published
2009

3. [Conformationally altered proteins cause neurodegenerative diseases].

Author

Ingelsson M, Nilsson L, Basun H, Aquilonius SM, and Lannfelt L

Subjects
Alzheimer Disease genetics, Amyloid beta-Peptides chemistry, Amyloid beta-Peptides genetics, Amyloid beta-Peptides metabolism, Amyloid beta-Protein Precursor chemistry, Amyloid beta-Protein Precursor genetics, Amyloid beta-Protein Precursor metabolism, Amyotrophic Lateral Sclerosis genetics, Brain metabolism, Creutzfeldt-Jakob Syndrome genetics, Dementia genetics, Humans, Huntington Disease genetics, Lewy Body Disease genetics, Mutation, Parkinson Disease genetics, Prions chemistry, Prions genetics, Prions metabolism, Superoxide Dismutase chemistry, Superoxide Dismutase genetics, Superoxide Dismutase metabolism, alpha-Synuclein chemistry, alpha-Synuclein genetics, alpha-Synuclein metabolism, tau Proteins chemistry, tau Proteins genetics, tau Proteins metabolism, Nerve Tissue Proteins genetics, Neurodegenerative Diseases genetics
Abstract

Brain aggregates of conformationally altered proteins are key features of neurodegeneration and are believed to directly cause or contribute to disease development. Mechanisms underlying the dysregulation of proteins in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and other neurodegenerative disorders are now being characterized, due to the discovery of genes causing rare disease forms. As of today, only symptomatic pharmacotherapies are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure these devastating disorders.

Published
2005

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