Introduction. Urban societies produce solid and liquid waste in a growing quantity. For a long time, several alternatives have been used for managing such wastes in an integrated way, but those alternatives are now out fashioned. Objective. To compare two anaerobic digestion systems with and without separation of the hydrolytic phase in a laboratory scale, for the biomethanization of the organic fraction of urban solid waste (FORSU, in Spanish) and domestic waste water (ARD in Spanish), evaluating its performance under efficiency for eliminating organic matter and methane generation terms. Materials and methods. Two systems of anaerobic methanization were compared in a laboratory scale. Mesophilic, the first one, was an anaerobic reactor of ascending flow (R1) and the second was a system separated into two phases: Hydrolytic reactor of ascending flow (R2) and an anaerobic ascending flow reactor of sludge blanket (UASB). The carbon source used was the organic fraction of urban solid waste and domestic urban waste water. Both systems were evaluated during 120 days. Results. For R1, the maximum organic charge speed (VCO in Spanish) was 4,7 Kg, chemical oxygen demand (COD)/m³-d, time of hydraulic retention (HRT), 24 hours, pH 7,01 at 7,77 to obtain a methane performance of 0,17 L/g initial volatile solid. On the other hand, the R2+UASB, the maximum organic charge speed to depurate was 17 Kg chemical oxygen demand m³-d, the HRT for R2 was 24 hours and for the UASB was 12 hours, with a pH for R2 between 4,92 and 5,34, and for the UASB, between 6,60 and 7,80, obtaining a methane performance of 0,29 L/g initial volatile solid. The highest production of volatile fatty acids was registered in R2 with 46,96g/L expressed in acetic acid (HAc). The elimination rate of chemical oxygen demand in R1 was 91% and the elimination rate of volatile solid was 92%. For R2 +UASB the chemical oxygen demand eliminated was 96% and the volatile solid was 97%. Conclusion. Applying a hydrolytic reactor to an UASB allowed removing more organic charge and a better methane production. [ABSTRACT FROM AUTHOR]