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Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Almost all guidelines and recommendations for the treatment of pneumonia acquired in the community requiring hospitalization indicate as first line of treatment cephalosporins of third-generation and a macrolide, and emphasize that local antimicrobial resistance must be considered since fluoroquinolone such as levofloxacin or moxifloxacin can play an important role. Objective: To determine whether levofloxacin is as effective as conventional therapy with ceftriaxone plus clarithromycin for the management of the community-acquired pneumonia in hospital centers of Health Ministry of Mexico. materials and method: An open-label randomized and controlled trial was performed in two hospitals of Mexico City. Sample size was calculated for a significance alpha < 0.05, comparing the response to two antibiotic regimens in the treatment of community-acquired pneumonia requiring hospitalization [group 1 (n=36), ceftriaxone plus clartithromycin, and group 2 (n=36) levofloxacin. Secondary objectives were to determine hospital mortality and the relationship of risk factor for treatment failure. Results: Statistical analysis did not show a statistically significant response (p < 0.114) for healing between the two treatment groups. There was not significant difference in mortality. It was determined as a risk factor for the lack of response to antibiotics having any sequel of neurological disease, and for the lack of response to levofloxacin, chronic alcoholism. Conclusions: Levofloxacin is as effective as ceftriaxone plus clarithromycin as initial antibiotic therapy in the management of community-acquired pneumonia. [ABSTRACT FROM AUTHOR]

Copyright of Medicina Interna de Mexico is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Diabetes Mellitus with its chronic complications is a major cause of morbidity and mortality. It has come to chronic hyperglycemia as the condition responsible for the development of chronic complications. Methods: Randomized controlled trial. We included 70 patients diagnosed with type 2 diabetes mellitus. 35 patients received placebo and 35 patients were treated with vitamin C and E at a dose of 2 g and 200UI respectively. For statistical analysis we used mean, standard deviation, U-Mann-Whitney and t-Student. Results: The mean age for the placebo group was 55.77 years and for group of vitamin C and E of 54.23 years, with statistically significant difference p 0.018 (95% 0.963-10.12, p <0.05). The most widely used drug treatment in both groups was the concomitant administration of glibenclamide and metformin. As for glycated hemoglobin levels the differences after of 3 month follow-up was mean 7.7% for placebo group and 6.9% for vitamin C and E with p 0.004 (95% CI 0.28 - 1.41, p <0.05). As for other study variables were differences in systolic blood pressure values with an mean of 131 mmHg and 125 mmHg for placebo group and group with intake of vitamin C and E, respectively (95% 0.741-10.40, p <0.05). Conclusion: The administration of vitamin C and E as adjuvant treatment of patients with diabetes reduces glycated hemoglobin levels and systolic blood pressure levels. [ABSTRACT FROM AUTHOR]

Copyright of Medicina Interna de Mexico is the property of Colegio de Medicina Interna de Mexico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)