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Introduction: Current epidemiological transition from infectious to chronic-degenerative diseases is more and more demanding procedures requiring contrast medium, which turns out to be a risk factor for acute renal major damage in patients with chronic kidney disease. The aim of this article is to describe the frequency and evolution of Contrast-induced nephropathy in ambulatory patients with chronic kidney disease undergoing percutaneous coronary intervention. Methods: We included patients with renal damage at the time of exposure to the contrast medium. They took a risk and were adjusted prevention measures follow at 48 hrs. Statistical analysis was performed using descriptive statistics. Results: From 1236 cardiac catheterization procedure performed, 32 patients met the inclusion criteria. The 96.87% had chronic degenerative diseases such as diabetes or hypertension, overweight and obesity were a constant in 65.62% of cases, in 21.7% of patients the contrast dose was slightly higher than recommended. The 6.3% developed contrastinduced nephropathy with elevated creatinine greater than 25% at 48 hours after the procedure, despite preventive measures, however none of them required renal replacement. Conclusions: The frequency of contrast medium-induced nephropathy in patients with high risk factors was lower than that reported in the literature; this may correspond to that in all cases nephrology assessment was performed before the procedure. [ABSTRACT FROM AUTHOR]