Abstract: The molluscan content from three “marine terraces” (TM) preserved along 250 km of the Santa Cruz province provided 49 molluscan taxa (33 Gastropoda and 16 Bivalvia) and the first Quaternary records for Ataxocerithium pullum, Crepidula protea, C. aculeata, Adelomelon ferrusacii, Brachidontes rodriguezi, Aequipecten tehuelchus, Ostrea tehuelcha, and Solen tehuelchus. The mollusca assemblages suggest typical marine nearshore conditions similar to the adjacent modern littoral (Southwestern Atlantic), with mostly hard substrates, shallow and cold waters. The TMVI (+5–15 m a.s.l., ca. 8–1.2 ka A.P.) is mainly characterized by dominance of Brachidontes spp., Nacella spp. and Mytilus edulis, associated with Siphonaria lessoni. No evidence has been found for the TMVI of clear biotic responses or strong palaeobiogeographic effects during the time span of the Climatic Optimum (“Hypsithermal”, mid-Holocene) which has been documented for other coastal areas northward in Argentina, down to ca. 44–45° S. Scarce differences distinguish the TMV (+15–30 m a.s.l., ca. 108–137 ka A.P., MIS5?) and TMIV (+20–30 m a.s.l., ca. 242 ka A.P.) regarding the Holocene and the modern littoral. Within the TMV, Clausinella, Eurhomalea, Solen tehuelchus and Brachidontes cf. darwinianus (typically in warmer waters) are exclusive; in the TMIV, Trophon, Buccinanops, Brachidontes and Pectinidae are characteristic. Predominance of Trophon spp. (typically in cold Magallanic waters) in modern samples vs. scarcity or absence in the TM suggest slightly lower modern SST. Several taxonomic similitudes with the Pacific Sudamerican coast (e.g., Fissurella, Nacella, Tegula, Crepidula, Trochita, and Acanthina) could respond to cold currents helping cold-water immigrants to join southern Southamerican Atlantic after the opening of the Drake Passage. [Copyright &y& Elsevier]