Search

In this paper, I will critically assess a very popular interpretation of Heidegger's early thought, according to which meaning (Bedeutung) is conceived as ontologically dependent on human existence (Dasein). To criticize this subjectivist understanding of meaning, I will offer an interpretation of Heidegger's analysis of signs in Being and Time (§17). This will reveal two main things: first, that the ubiquity of sign phenomena is founded on the universality of the structure known as reference (Verweisung); second, that Heidegger's idea of reference offers a non-substantialist understanding of meaning and its relation to the world. [ABSTRACT FROM AUTHOR]

The increasing prevalence of mild cognitive impairment (MCI) comorbid with arterial hypertension requests the revision and enhancement of available interventions. The goal of this study was to compare the effect of cognitive rehabilitation (CR) and other forms of stimulation on cognitive functions. Using a quasi-experimental design and a convenience sampling, the reception of four natural stimuli (physical and intellectual activities, hobbies, work) was collected from 128 hypertensive patients aged over 55 years with cognitive (at least two areas) and vascular impairment. Forty-four of them willingly participated in CR sessions. The effects of CR and natural stimuli on five cognitive functions were compared, three related to language (comprehensive, denominative, and fluent language), global memory and attention, assessed with the ACE Test (attention, memory, verbal fluency and language domains). Multivariate modeling analysis for repeated measures was used, controlling for potentially confounding variables. Main results show that younger age and higher academic trajectory predict better initial levels of the evaluated functions. CR is associated with gains in attention, memory and verbal fluency. Written home cognitive activities show also positive effects. The larger gains are observed in participants with higher cognitive impairment and lower academic trajectories. The postulate of the remaining cognitive reserve would synthesize these phenomena. The study concludes that CR is the preferred form of stimulation, followed by home intellectual exercises for the maintenance and partial recovery of cognitive functions in patients with mild cognitive impairment and hypertension. [ABSTRACT FROM AUTHOR]

México es el primer lugar a nivel mundial en obesidad; la Diabetes tipo 2 se encuentra asociada hasta en 90%. Este estudio observacional ambispectivo del 2009 al 2015, compara las tasas de remisión de diabetes tipo 2 en pacientes con IMC >35 kg/m² operados de Bypass Gástrico Laparoscópico (BPGL) vs Gastrectomía Vertical en Manga Laparoscópica (GVML) monitorizando la normalización de los niveles de glucosa plasmática, disminución del porecentaje de HbA1C y cese en el uso de antidiabéticos por lo menos un año, siendo ese su objtetivo. Se analizaron los expedientes clínicos de los pacientes operados de BPGL y GVML con obesidad mórbida y diabetes tipo 2 en el periodo de enero del 2009 a junio del 2015, registrando en una base de datos las variables medibles de cada paciente. Se utilizó una tabla de ANOVA y la prueba t de Student mediante programa de análisis de datos SPSS®. Posterior a la cirugía se registraron cifras de glucosa en ayuno <100 mg/dl desde los primeros tres meses en la mayoría de los pacientes. Después de 12 meses de seguimiento los niveles de glucosa descendieron de 152.16 ± 65.3 mg/dl a 88.16 ± 14.05 mg/dl (p< 0.001), el porcentaje de HbA1C bajó de 7.4 ± 1.4 a 5.3 ± 0.8 (p <0.001), cuatro pacientes continuaron con algún tipo de medicamento, dos con insulina y dos con hipoglucemiantes orales. Existió una remisión de la diabetes tipo 2 en 20 pacientes (80%). En los pacientes con obesidad mórbida y diabetes tipo 2 tratados en el Hospital Central Militar, la GVML y el BPGL han demostrado seguridad y efectividad en la remisión de diabetes tipo 2 a mediano plazo. Sin diferencia significativa entre ambos. [ABSTRACT FROM AUTHOR]

Copyright of Revista de la ALAD is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archivos Latinoamericanos de Nutrición is the property of Sociedad Latinoamericana de Nutricion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS), belongs to the group of inflammatory disease of the central nervous system with a predilection for the pontine structures. Case report: Herein we present a case of a Mexican patient clinically and radiologically with excellent response to steroids and inmunomodulatory therapy. Conclusion: There exist less tan 100 reported cases of CLIPPERS worldwide. In this paper systematic literature research is also provided. [ABSTRACT FROM AUTHOR]

BACKGROUND: The clinical disease activity index (CDAI) with 28 joint counts measures the activity of rheumatoid arthritis (RA) without laboratory tests. OBJECTIVE: To evaluate the CDAI in daily practice in RA patients at one year of the symptoms onset. MATERIAL AND METHOD: A prospective study was done with 120 consecutive patients with early RA ≤ 12 months (101 women, 19 men) seen in the rheumatology consult within 1 year of symptoms onset. The CDAI was divided into four categories: high or severe activity >22, moderate >10-22, mild <10 and remission ≤2.8. Functional disability (HAQ, health assessment questionnaire, 0-3 score) was also evaluated. A combination of methotrexate and sulfasalazine or chloroquine and low-dose prednisone 2.5-5.0 mg/d was administered. RESULTS: At baseline, 88 (73%) patients had high activity and 32 (27%) had moderate-mild activity. At 6 months 3% had high activity, whereas 96 (80%) were in remission (median 0, range 0-2.6). At 12 months, 110 patients (91%) were in remission and 6 (5%) had mild activity. The median score of HAQ was 1.4 (range 0.5-3.0) and at 12 months was 0 (range 0-1.2) There was a good correlation between HAQ and CDAI. CONCLUSION: The CDAI score is a clinical tool that omits laboratory tests. Remission, defined as a CDAI ≤2.8 was achieved so early as 6 months. This study also showed improvement in functional ability. [ABSTRACT FROM AUTHOR]

Objective: To find out the factors that are associated with sustained remission measured by DAS28 and boolean ACR EULAR 2011 criteria at the time of diagnosis of rheumatoid arthritis. Materials and methods: Medical records of patients with rheumatoid arthritis in sustained remission according to DAS28 were reviewed. They were compared with patients who did not achieved values of DAS28 < 2.6 in any visit during the first 3 years after diagnosis. We also evaluated if patients achieved the boolean ACR/EULAR criteria. Variables analyzed: sex, age, smoking, comorbidities, rheumatoid factor, anti-CCP, ESR, CRP, erosions, HAQ, DAS28, extra-articular manifestations, time to initiation of treatment, involvement of large joints, number of tender joints, number of swollen joints, pharmacological treatment. Results: Forty five patients that achieved sustained remission were compared with 44 controls. The variables present at diagnosis that significantly were associated with remission by DAS28 were: lower values of DAS28, HAQ, ESR, NTJ, NSJ, negative CRP, absence of erosions, male sex and absence of involvement of large joints. Only 24.71% achieved the boolean criteria. The variables associated with sustained remission by these criteria were: lower values of DAS28, HAQ, ESR, number of tender joints and number of swollen joints, negative CRP and absence of erosions. Conclusion: The factors associated with sustained remission were the lower baseline disease activity, the low degree of functional disability and lower joint involvement. We consider it important to recognize these factors to optimize treatment. [ABSTRACT FROM AUTHOR]

Evidence from numerous clinical studies has shown that the optimal goal for the treatment of depression is remission. Remission implies that the signs and symptoms of the disease are absent or virtually absent, which is typically associated with a return to the patient's previous daily functioning. Functioning in depression is a broad concept that covers different domains. There are many validated instruments for its assessment, these being reviewed in this article. Furthermore, recovering the pre-morbid level of functioning level is increasingly being identified as a significant target in addition to symptomatic remission. In this sense, functional recovery has been associated with better prognosis of depression and is also a clinical goal expressed by the patient. Several factors, like complete remission of symptoms, with no residual symptoms, maintenance of remission, quality of remission, early remission, have been identified as contributors to functional recovery. In order to facilitate the clinical outcomes, evaluation of and search for symptomatic remission as well as functional recovery need to be integrated into the clinical practice. [ABSTRACT FROM AUTHOR]

Introduction Anorexia nervosa is a suffering entity from eating disorders and family has a relevant role in this disorders; a severe family dysfunction is a risk factor and an important maintainer factor. On the other hand, the family's participation in treatment increases the possibility of success. The aim of this paper is to contribute with the analysis of the form on which the subjects, who suffer from anorexia nervosa and their parents, coexist with their suffering, and share their story. Materials and methods It is a qualitative research study that pretends to know about the family's experiences. The informants where selected according to a theoretical non probabilistic sample. Depth interviews were used and the material was analyzed through a narrative analysis by thematic axis according to Kolher Riessman model. Results The presented family is formed by three members, mother, father and daughter, with anorexia nervosa. Presenting excessively restrictive behaviors oscillating between control and impulsivity. The mother turns her into her confident and the father is too strict and demanding. Concerning the treatment, it lasted approximately three years on impasse, the patient did not show any evolution. Discussion The four evolution moments of the suffering had several points of view according to each of the informants, in literature, the mother and daughter's symbiotic relationship and the peripheral relationship established with the father are mentioned, change was achieved in the family alliances and the change in the nature of their bonds was facilitated. Conclusions These findings are an initial step to know the experiences of each of the family members during the treatment and the expectations they have towards the remission of the suffering. [ABSTRACT FROM AUTHOR]

The current article claims to state clearly the Heidegger's notions of world, useful things and object based on a story of Leonardo Boff called "The sacrament of the glass". It is the familiar world of the Boff that appears when they drink from an old jug that had been with Leonardo and his family from his childhood. Used as starting point this story seeks to show the phenomenon of the reference, from this notion to explain the phenomena of the world and the useful things. Finally from the phenomenon of useful things to gain access to the knowledge's kind of being and to the object appearing in this kind of being. Heidegger's words used in this abstract respond to those from translation to English of Sein und Zeit of Joan Stambaugh and those used in this article respond to the translation to Spanish of Sein und Zeit of Jorge Eduardo Rivera. [ABSTRACT FROM AUTHOR]

Copyright of Schizophrenia Bulletin - Edición Española is the property of J&C Ediciones Medicas S.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Eryropoietin has allowed to avoid anemia in patients with neoplasias, and to reduce its transfusion requirements. Objective: To evaluate if 25,000 UI of recombinant erythropoietin (EPOr) is useful to increase hemoglobin levels (Hb) and to decrease transfusional requirements in patients with acute lymphoblastic leukemia in consolidation and maintenance chemotherapy. Patients and methods: Prospective study in patients with diagnosis of acute lymphoblastic leukemia, with complete remission, and receiving consolidation and maintenance chemotherapy, during 1 to 6 cycles. Patients were randomized to receive EPOr (25,000 UI once weekly), and transfusional support if Hb decreases less than 8.5 g/dL (EPO group). The other group (NoEPO) recieives transfusional support only if Hb was lower than 8.5 g/dL. Results: Both groups were similar in age, sex, and chemotherapy and leukemia type. At the end of the study patients receive 96 cycles of chemotherapy: 52 in EPO group and 44 in NoEPO group (p = 0.0005). Hb mean in EPO and No EPO groups was 12.7 g/dL and 10.8 g/dL, respectively (p = 0.001). In EPO group patients received only 2 red cells package and 13 in NoEPO (p = 0.005). Conclusion: Use of EPOr increase levels of Hb and decrease transfusional requirements, in comparison with the group of patients who don't receive it. [ABSTRACT FROM AUTHOR]

In the long-term management of depression is necessary to take into account some key concepts: evolutive characteristics of depressive episodes, first clinical episode onset, number of episodes, duration, intervals and cycles, course of illness, etc. Long-term treatment is a broad term that would include the treatment or therapeutic strategy used once the acute treatment is over. It has been divided into continuation or consolidation treatment and maintenance or prophylactic treatment. Conceptually, other terms and definitions are relevant: partial remission implies a depressive symptomatology without criteria for a complete episode or syndrome. Response may be considered once partial remission has begun. Partial remission may be spontaneous, though there is a trend to assume that is secondary to the study drug's effectiveness. The absence of evolution of partial to total remission creates the need to test new therapeutic strategies. Residual symptoms are the first step to more severe ones such as episodic relapse and chronicity. «Residual symptomatology» is associated in literature with a higher rate of relapses. Full remission implies lack of significant depressive symptoms for a determined period of time (at least 2 months). Recovery is a continuum between absence of depressive symptoms and mild or moderate symptoms. Relapse is defined by a clinical episode at least 6 months after the previous one and recurrence over 6 months. [ABSTRACT FROM AUTHOR]

Introduction. The aim of this observational study was to evaluate the long term effect of treatment with venlafaxine extended release on response and remission in patients with depressive syndrome and associated anxiety symptoms, in primary health care. Methods. Observational, naturalistic and prospective, open-label study. Inclusion criteria were as follows: age over 18 years, diagnosis of depressive syndrome with anxiety symptoms and minimum scores of 17 and 10 on Hamilton Depression Rating (HAM-D17) and Anxiety Rating (HAM-A) scales, respectively. Daily doses of 75-150 mg of venlafaxine extended release were administered for 24 weeks. Effectiveness on the depressive-anxious symptoms was assessed using the HAM-D17 and HAM-A scales. Response and remission criteria were considered. Results. 6,719 patients were evaluable for effectiveness and safety -- intention to treat population. Venlafaxine extended release treatment was associated with significant decreases in the scores in the HAM-D17 and HAM-A scales, as well as with significant increases in response and remission rates. At week 24, remission rates were: 74.62 % (HAM-D17 ≤ 7), 81.55 % (HAM-A ≤ 7) and 72.63% (HAM-D17 ≤ 7/HAM-A ≤ 7). 81.8% of patients completed 24 weeks of treatment. 6.4 % of patients reported adverse events, of mild-moderate intensity in 94.9% of cases. Conclusion. In this study, venlafaxine extended release shows that it is an effective and safe drug in the treatment of the depressive-anxious symptoms of patients with depressive syndrome treated in primary care, both in remission and response rates. It would be of interest to compare data of venlafaxine extended release with that of other antidepressive drugs, such as SSRI. [ABSTRACT FROM AUTHOR]

Objectives. To determine and compare effectiveness, tolerability and safety of venlafaxine extended release (VXR) and other conventional antidepressants, mainly selective serotonin reuptake inhibitors (SSRIs), for the treatment of elderly patients diagnosed of depressive disorder in an out-patient psychiatry setting. Methods. Multicenter, naturalistic, randomized, open-label study performed in elderly patients with depressive disorder (according to DSM-IV). Patients were randomized to 6 months of treatment with VXR or another conventional antidepressant (CA). Effectiveness was assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Anxiety Scale (HAM-A). Response was considered as a ≥ 50 % decrease and remission as a < 9 score in the MADRS. Results. Sample of 120 patients older than 60 years; 68 received VXR and 52 CA (SSRI: 94.1 %). Most frequently used SSRI were citalopram (40.8 %), paroxetine (24.5 %) and sertraline (20.4 %). After 6 months of treatment, VXR achieved a higher response (75 %, VXR; 50 %, CA; p = 0.048) and remission (50 %, VXR; 28.9 %, CA; p = 0.048) and a higher decrease in the HAM-A score (-14.77, VXR; -10.84, CA). There were no significant differences in compliance rates (67.6, VXR; 71.1 %, CA) and adverse reactions (14.7 %, VXR; 13.46 %, CA) between both treatment groups. Blood pressure and heart rate remained within normal, limits in both treatment groups. Conclusions. In this study, venlafaxine extended release shows higher effectiveness than other conventional antidepressants, mainly SSRIs, in the treatment of depressive elderly patients in the out-patient psychiatry setting. [ABSTRACT FROM AUTHOR]

Case presentation of a 62-year-old woman patient with chronic pathologies and multiple symptoms, who consulted the internist for several symptoms associated with chronic conditions. The doctor ordered several exams and required their completion in the institutions that he indicated to the patient, despite she insisted on performing them at a known clinic near to her home. The patient learns that her doctor receives economic incentives for the referral and reports it. The ethical lack that is configured is analyzed, denominated dichotomy with its different variants, the risk it generates for an exercise with professionalism and ethics and the prohibition of the same is explicit by Law 23 of 1981 or Colombian medical ethics law. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis is a chronic systemic inflammatory disease that causes significant morbidity and mortality. The combined use of methotrexate and biological agents directed against tumor necrosis factor (TNF) has achieved significant improvement in clinical, radiographic and functional parameters not seen previously and has revolutionized the therapeutic goal of achieving remission in clinical, structural and functional parameters. The next goal should be to achieve remission without the use of biological drugs and later without medication. Although there is evidence about the efficacy and safety of TNF inhibitors, there is none on remission without the use of biological agents or disease modifying drugs. [ABSTRACT FROM AUTHOR]

Affective disorders are conditions with a high rate of relapse and recurrence. There are specific predictors of recurrence. Clinical trials with 24 month at least as duration with prevention of relapses and recurrence are scare (11 with a total sample of 967 randomized patients in the maintenance phase). Amitriptiline, imipramine, fenelzine and venlafaxine extended release can be considered as a first line treatment according the data from those clinical trials. Some psychotherapies has also positive results with important methodological problems in the design of the studies. Suicide, drug abuse including alcohol and comorbidity with medical disorders are the more severe and frequent long-term complications. A mood stabiliser drugs is necessary in bipolar depression. Elderly people are a population group characterized for the severity and recurrence of depressive episodes. [ABSTRACT FROM AUTHOR]