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Objectives: To review the clinical characteristics, diagnosis, treatment and visual outcome in patients with diagnosis of Acanthamoeba keratitis. To demonstrate the importance of early diagnosis, and prompt and effective treatment. Methods: Retrospective study of 14 eyes in the same number of patients diagnosed with Acanthamoeba keratitis, which were treated in Centro Visión in the period from July 2008 to June 2012. All cases were confirmed by smear and/or culture. There were two groups: early and late. The treatment was performed with polyhexamethylene biguanide and propamidine as previous protocol. After the cure of the infection, final visual acuity and the duration of treatment were recorded. Results: The most often affected group was between 21-40 years old (9 cases). Only two eyes (14,3%) were initially correctly diag- nosed as QA. Eleven patients (78,6%) were contact lens wearers. The most common sign was diffuse infiltrate (62.3%), perineural infiltration was seen in only one case. Five patients were diagnosed within the first thirty days (early group) and nine patients later (late group). The median visual acuity after treatment was 20/40 in the early group, and 20/400 in the late group. The median duration of treatment was six months in the early group, and ten months in the late group. Conclusions: Most cases (85.7%) were initially erroneously classified as another cause keratitis. When Acanthamoeba keratitis is early diagnosed, there is a better visual prognosis, and also will not need longer treatment. [ABSTRACT FROM AUTHOR]