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Copyright of Gaceta Médica de Caracas is the property of Academia Nacional de Medicina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: The severity of COVID-19 infection in kidney transplant patients has been well-documented. Objectives: This study aims to determine the epidemiological and clinical data and identify predictors of poor prognosis during the epidemic's early stages. Material and methods: This is a national semi-prospective, multicenter study of subjects with functioning grafts who were infected during the first wave of the pandemic in Chile between March 1 and September 31, 2020. Results: during this period, we recorded the hospitalization of 97 adult patients throughout the entire national territory. The average age was 52.5 years, 62% men, 45% hypertensive, 11% coronary, 10% diabetic, and 5% with chronic obstructive pulmonary disease, with an average post-transplant follow-up of 7.2 years and an average previous renal function of 47.7ml/min/1.7m2 (CKD-EPI formula). Between the onset of symptoms and diagnosis, there was an average period of 4.8 days, with a predominance of cough (44%), dyspnea (42%), and fever (42%). 34% developed acute kidney injury, and 36% of them required dialysis support. The lethality was 30%, prevailing in those with multiple organ failure (80%) and those who required invasive mechanical ventilation (52%). In the multivariate analysis, the best predictors of mortality were older age (OR: 2.92) and living in a low-income commune (OR: 2.35). Conclusions: This national project of the Chilean Society of Nephrology provided valuable information for monitoring the epidemiological evolution of the pandemic. It also helped to propose priority vaccination strategies, adjust immunosuppressive therapy, and design logistical aspects to reduce the risks for transplant patients. [ABSTRACT FROM AUTHOR]

Copyright of Argentinian Journal of Respiratory & Physical Therapy (AJRPT) is the property of Asociacion Civil Cientifica de Difusion y Promocion de la Kinesiologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Médica Clínica Las Condes is the property of Editorial Sanchez y Barcelo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de la Facultad de Medicina Humana is the property of Instituto de Investigaciones en Ciencias Biomedicas de la Universidad Ricardo Palma and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tesla Revista Científica is the property of Puerto Madero Editorial Academica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tesla Revista Científica is the property of Puerto Madero Editorial Academica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Salud UIS is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Argentina de Terapia Intensiva is the property of Sociedad Argentina de Terapia Intensiva (SATI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Universidad Médica Pinareña is the property of Editorial Ciencias Medicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Médica Peruana is the property of Colegio Medico del Peru and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Gerokomos is the property of Indemm Farma SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Médica de Risaralda is the property of Universidad Tecnologica de Pereira and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper aims to review, discuss and define the factors associated with development of kidney injury in patients with sepsis, diagnosis alternatives, therapy and prevention, offering to the veterinarians an updated guide to improve the prognosis of sepsis patients. Sepsis is a clinical condition that leads to systemic complications and to multiple organ dysfunction syndrome (MODS), mainly due to poor tissue perfusion in humans and animals. Acute kidney injury (AKI) is considered the most frequent and lethal among organ complications secondary to sepsis, however the etiology of AKI in patients with sepsis is complex and multifactorial and not completely elucidated. Early diagnosis of AKI is difficult and consequently the treatment is not very successful, due to hemodynamic aspects. The ultrasonography seems to be a promising exam for early diagnosis of this lesion, especially with the advent of contrast-enhanced ultrasonography (CEUS) technique, which makes possible to detect microcirculation changes in the renal parenchyma, opening the door for a variety of physiological, clinical and therapeutic applications, however, studies proving CEUS accuracy for early detection of renal damage related to sepsis in humans and animals are still necessary. [ABSTRACT FROM AUTHOR]

The article presents a clinical case in which a percutaneous bilateral ductal stent implant was performed on an Andean newborn with disconnected pulmonary arteries and pulmonary atresia. A non-medicated chromium-cobalt stent was used to ensure permanent pulmonary blood flow. Although the procedure was successful, the patient developed subsequent complications and died due to pneumonia related to healthcare and multiorgan failure. The authors highlight the importance of being cautious when analyzing patients referred from institutions without experienced pediatric interventional cardiologists. [Extracted from the article]

Septic shock with multi organ dysfunction is associated with a mortality above 50%. We present here the case of a young male patient who presented with septic shock and multi organ dysfunctions secondary to methicillinsusceptible Staphylococcus aureus from a skin and soft tissue infection presenting with alveolar-nodular pulmonary lesions, purulent pericarditis and septic embolic lesions on the skin, eyes and kidneys. The patient was admitted to the ICU receiving antibiotic coverage with oxacillin and vancomycin, subtotal pericardiectomy and pleural drainage, and was discharged clinically stable. We present this case to draw attention to the severity of S. aureus bacteremia to initiate prompt aggressive therapeutic measures to ameliorate associated morbidity and mortality. [ABSTRACT FROM AUTHOR]

Copyright of Ciencia, Tecnología y Salud is the property of Ciencia, Tecnologia y Salud and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ciencia, Tecnología y Salud is the property of Ciencia, Tecnologia y Salud and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Currently, multiple clinical and paraclinical variables have been found to predict prognosis in patients with VOC-19. The clinical presentation may be mild, moderate, or even present as acute respiratory distress syndrome (ARDS) and multisystem organ failure (MSF) with fatal outcome. The identification of prognostic factors, both clinical and paraclinical, will allow the grading of patients' risk and the active control of the severity of the disease. The main objective was to determine the clinical and paraclinical variables predicting prognosis in patients with FOM- 19. A systematic review will be conducted. The search will be performed in the following databases: PubMed, Taylor and Francis, LILACS, Springer, Scopus, Web of Science and CINAHL. The search will use keywords based on DeCs and MeSH categorization, using the Boolean AND and OR connections. The variables (clinical history) for this study will be as follows: Age, signs and symptoms, history, mortality, laboratory tests, habits and treatments. The aim is to provide scientific evidence and create national statistics to facilitate the use of prognostic variables in the evolution of the disease; in this way, we will be able to get a close look at this new disease we are facing, according to our population reality. [ABSTRACT FROM AUTHOR]

Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article describes a clinical case of heart disease and kidney disease in a captive churuco monkey at the Los Ocarros biopark in Colombia. The monkey presented symptoms such as lack of appetite and weakness, and was administered treatments such as Oxytetracycline and Belamyl R. Clinical and diagnostic tests were performed, revealing cardiomegaly, heart failure, and kidney disease. Despite the treatment, the monkey died due to systemic multiorgan failure. The necropsy revealed congestive heart failure and chronic renal failure as possible causes of death. [Extracted from the article]

Carrion's disease is an endemic disease in Peru caused by Bartonella bacilliformis presenting with an acute or hemolytic form and a chronic verrucous form with asymptomatic bacteremia. The acute form is usually serious and is associated with high morbidity and mortality. We report the case of a case of a young pregnant woman from Yungay, Ancash who presented with the acute form complicated with multi organ failure and acute respiratory distress syndrome needing mechanical ventilation and dying. [ABSTRACT FROM AUTHOR]

Introduction. Sepsis is defined as a multiple organ dysfunction secondary to an infectious process that can progress to septic shock, increasing the risk of mortality. Recent findings pertaining to Sepsis allow us to perform early diagnoses and timely therapeutic treatments with short and medium-term reductions in mortality. Division of Covered Topics. Non-systematic literary research was conducted in databases and digital libraries (PubMed, Cochrane, Lilacs), including articles in English and Spanish from 2005 to 2018 that included the topics of interest. A detailed description was made of the definition of sepsis and septic shock, their classification, physiopathology, diagnosis, hemodynamic monitoring and treatment. Conclusions. Sepsis is a medical emergency with a high mortality rate that requires a timely diagnosis. The diagnosis can be performed with the Sepsis Related Organ Failure Assessment (SOFA) score, and quickly beginning empirical antibiotic treatment and reanimation guided by goals, as these measures have shown a reduction in fatal outcomes. [ABSTRACT FROM AUTHOR]

The presence of lymph of thoracic or intestinal origin in the abdominal cavity is defined as chylous ascites, an infrequent disease, usually associated with another disease of difficult diagnosis in which the treatment, commonly, does not achieve good results. The contribution of this work is to report the cases of two female patients in whom chylous ascites was diagnosed at the D Medicine Ward of the Arnaldo Milián Castro Hospital, and to carry out a review of the physiopathology, clinical presentation, etiologies, diagnosis and treatment of this disease. The clinical and evolutionary data of the two patients were summarized. They did not present a traumatic, infectious, neoplastic or surgical history that could account for chylous ascites. The diagnosis was made by the appearance of the liquid, which was obtained by paracentesis and by its cytochemical study, with triglyceride content above 200mg/dl in both cases. The cause of chylous ascites was liver cirrhosis in one of the patients and cancer of the uterus with lymphatic invasion in the second. Both patients died; the former due to bacterial peritonitis and dysfunction and failure of multiple organs, and the latter due to malnutrition, peritonitis and infiltration of the omentum due to adenosquamous carcinoma of the endometrium infiltrating the myometrium. [ABSTRACT FROM AUTHOR]

Objective: To determine BISAP as a predictor of mortality in acute pancreatitis in the Emergency Service. Materials and methods: A cohort study in acute pancreatitis in emergency service, two groups were formed according to BISAP score, low risk (0-2) and high risk (3-5). The total sample for each group was 23.76, nevertheless it was worked with 111 patients of low risk and 23 of high risk. The sampling technique was non-randomized by quota. Mortality was measured at 24 h and at 7 days. Statistical analysis included logistic regression and probability calculation. Results: When the BISAP score is high risk the probability of dying at 24 h is 22.7% and 76.5% at 7 days (Chi² = 13.91, P = .002). Discussion and conclusion: The BISAP score allows predicting the probability of dying at 24 h and at 7 days. [ABSTRACT FROM AUTHOR]

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

During the last decade, the understanding of molecular and cellular level of inflammatory injury has increased, although this knowledge has not meant a critical change in the daily practice of systemic inflammatory syndromes even though promising results have come in some scenarios (Protein C usage in patients with sepsis or septic shock). [ABSTRACT FROM AUTHOR]

Following any aggression, the body starts an infl ammatory response, mediated by humoral and cellular factors, intended to limit the process and eventually to heal. In some cases, either due to the intensity or the duration of the aggression or due to an inadequate response of the host, secondary to genetic polymorphisms, malnutrition or other causes, a state of hyper activation of infl ammatory cells is originated, with liberation of immature cells and activation of monocytes and macrophages, which liberate very powerful pro infl ammatory mediators that induce a state of generalized systemic infl ammation. Many processes may originate this infl ammatory response, (sepsis, trauma, burns, pancreatitis, etc.) with activation of leukocyte, endothelial, coagulation and neuroendocrine response systems, generating a complex of mediators (cytokines, adhesion molecules, growth factors, etc.). Clinically, the response is characterized by infl ammation, anorexia, stillness, increase of vascular permeability, factors that originate edema and vasodilatation, which is followed by hypotension, tachycardia and increased cardiac output. On the other hand, the metabolic response to stress is part of the mechanism of adaptation, generated by the organism in order to survive the acute disease by means of increasing energetic substrates to vital tissues. As a result of this complex metabolic response, the control of substrate utilization is only partially regulated because, being impaired the mechanisms of energy supply, the organism seeks alternative substrates [ABSTRACT FROM AUTHOR]

We report the case of a 22-year-old female patient with a history of 2 fetal losses due to Cervical Incompetence. Cervical cerclage was made at the 10th week of her third pregnancy. At the 24th week of pregnancy, she was admitted to an emergency service for sepsis syndrome and fetal death, with sepsis of abdominopelvic origin. In an operating room the cerclage was removed and the dead fetus delivery was induced. She was admitted to an Intensive care unit, total abdominal hysterectomy and drainage was made 13 hours after, with subsequent abdominal lavage. She developed intravascular disseminated coagulation as part of multi-organic failure, which included: cardiovascular, lung, gastrointestinal, renal, liver and nervous system failure, barbituric coma was induced, the use of Recombinant Human Activated Protein C, was included and was discharged from the hospital two weeks later. The association between stillbirth and cervical cerclage was considered the most important factor related to the obstetrical septic shock. Patients with cervical cerclage need adecuate pregnant control, and they must be considered in the high-risk pregnancy group. [ABSTRACT FROM AUTHOR]

Background: Neutropenic enterocolitis is a complication manifested in cancer patients with neutropenia usually with absolute neutrophils counts of less than 500 cells/mm3. NEC clinically presents as acute abdomen and systemic inflammatory response syndrome. Up to 40 % of cases occur in patients with leukemia. There are few studied risk factors associated with mortality. Objective: To determine independent risk factors associated with mortality in patients with acute lymphoblastic leukemia and neutropenic enterocolitis. Methods: A nested case control study in a cohort of patients with neutropenic enterocolitis admitted to the pediatric intensive care unit of "Instituto Nacional de Pediatría" aged between one month and 17 years old. Cases were defined as subjects with acute lymphoblastic leukemia who were admitted to the pediatric intensive care unit and died from complications of neutropenic enterocolitis. Controls consisted in living patients with acute lymphoblastic leukemia who were admitted to the pediatric intensive care unit because of neutropenic enterocolitis and survived, two controls for sex and age were selected; 22 cases and 44 controls were obtained. Considered risk variables were: chemotherapy phase, type of chemotherapy, presence of organ failure, severity of sepsis and surgical management. Our statistical analysis consists in description of demographic variables, Fisher exact test for quantitative data and Mann-Whitney U testfor qualitative data. Risk analysis identified significant differences between the groups. Cox proportional risk analysis and Kaplan Meier graphs were done to express relative risk for mortality and survival differences respectively. Results: Most independent variables were: multiorgan dysfunction with relative risk of 57(95% CI 6.6-75; p < 0.001); septic shock with relative risk of 1 5 (CI 95% 2-56; p = 0.008), etoposide use with relative risk of 2.6 (95% CI 1-6.6;p = 0.01) and gastrointestinal bleeding with relative risk of 2.1 (95% CI 1.1 -5.5; p = 0.05). Conclusions: In a prospective cohort of patients with leukemia, who developed neutropenic enterocolitis, the variables most associated with mortality were multiorgan dysfunction and gastrointestinal bleeding. [ABSTRACT FROM AUTHOR]

Objectives. To implement a system for remote diagnosis of tuberculosis and multidrug resistance (MDR) using the Microscopic-Observation Drug Susceptibility Assay (MODS) method in the Mycobacteria Laboratory, Trujillo Center of Excellence in Tuberculosis (CENEX-Trujillo). The system included a variant of an algorithm for recognition of Mycobacterium tuberculosis recently reported from digital images of MODS cultures of sputum samples. Materials and methods. The recognition algorithm was optimized using a retraining statistical model based on digital images of MODS cultures from CENEX-Trujillo. Images of 50 positive MODS cultures of patients with suspected multidrug-resistant tuberculosis were obtained between January and October 2012 in the CENEX-Trujillo. Results. The sensitivity and specificity to recognize strings of tuberculosis were 92.04% and 94.93% respectively using objects. The sensitivity and specificity to determine a positive tuberculosis field were 95.4% and 98.07% respectively using pictures. Conclusions. The results demonstrated the feasibility of the implementation of telediagnostics in remote locations, which may contribute to the early detection of multidrug-resistant tuberculosis by MODS method. [ABSTRACT FROM AUTHOR]

We present two cases of cutaneous and systemic loxoscelism presented in an emergency service, one case was complicated by septicemia, acute renal failure and multiple organ failure. Contemporary treatments are also discussed. [ABSTRACT FROM AUTHOR]

Sepsis is still the leading cause of death in intensive care units. New therapeutic approach based on goals achieved to reduce the mortality rate, however continues to be high. During the evolution of the septic process, the systemic inflammatory response and metabolic response to trauma form the two main responses of compensatory type with which the organism is faced with sepsis. The different phases of the metabolic response to trauma denote different stages of organic adaptation, which often first evolves to a phase of multiple organ dysfunction and then a multiple organic failure. Basal energy expenditure in patients with sepsis is greatly diminished at the stage corresponding to multiple organ dysfunction. At this stage, the functional alterations that are observed are secondary to disoxia and decrease in the production of energy at the mitochondrial level. This phase of dysfunction is thought to be an adaptive phase of the body with the purpose of preserving the organic cell structure. In this article, we reviewed the mitochondrial alterations that are observed during the phase of multiple organ dysfunctions, its relationship with the therapeutic approach and the importance in mortality of these patients. [ABSTRACT FROM AUTHOR]

Background: the surgical correction of tetralogy of Fallot (TOF) is standardized on the way to close the septal defect, but differs in the way of expanding the right ventricular outflow tract (RVOT). The aim was to compare the early postoperative clinical course of the RVOT obstruction enlargement in classical ventriculotomy technique and the small infundibulectomy (SI). Methods: it was done an analysis of the database of pediatric heart surgery service from 2008 to 2011. Patients with non-complex TOF undergoing complete correction by classical ventriculotomy or SI were selected. Anova, χ² and Fisher statistical test were applied. Results: the data included 47 patients, 55 % (26) male, mean age 43 months (6-172), classical ventriculotomy was performed in 61.7 % (29), this group had higher peak levels of lactate (9.07 versus 6.8 mmol/L) p = 0049, greater magnitude in the index bleeding/kg in the first 12 hours (39.1 versus 20.3 mL/kg) p = 0.016. Death occurred in 9 cases (31.03 %) versus one (5.6 %) in the SI group with p = 0.037; complications exclusive as acute renal failure, hemopneumothorax, pneumonia, permanent AV-block and multiple organ failure were observed. Conclusions: morbidity and mortality was higher in classical ventriculotomy group in comparison with SI. This is possibly associated with higher blood volume. [ABSTRACT FROM AUTHOR]

The ventilator-associated pneumonia occurs in patients undergoing mechanical ventilation for periods longer than 48 hours. Ventilator- associated pneumonia incidence is reported in literature of 10 to 20% of patients. The early-onset ventilator-associated pneumonia is defi ned as pneumonia diagnosed between the third and seventh day. The late-onset ventilator-associated pneumonia is defi ned as pneumonia diagnosed after the seventh day. Many risk factors contribute to the development of ventilator-associated pneumonia. The most frequent associated are gram-negative bacilli: Aeuriginosa pseudomonas, Acinetobacter baumannii, and Stenotrophomonas maltophilia (40%), Enterobacter sp (29%), and Gram-positive cocci: Staphylococcus aureus (21%). Set a proper diagnosis of ventilator-associated pneumonia is one of the most important and diffi cult issues in the care of critically ill patients. There are strategies for the prevention of ventilator-associated pneumonia, but only a few have proven effective. The attributable mortality is still debated, and has been associated with ranges of 20-70%. [ABSTRACT FROM AUTHOR]

Twenty-six-year-old, female patient with a clinical history of Systemic Lupus Erythematosus, Lupus Panniculitis, and Antiphospholipid Syndrome. She was admitted to the emergency room after two days of symptoms of asthenia, fever, and profuse bleeding from ulcers in the lower limbs. Physical examination revealed generalized edema and tachycardia. The requested tests showed coagulation abnormalities, alterations in the complement and liver enzymes. Presence of Streptococcus spp bacteremia was also determined. Patient was hospitalized and antibiotic treatment was started. While she was in the hospital, she required close monitoring, active and multidisciplinary management by the medical staff of the institution due to severe and rapid health deterioration. However, despite treatment, the patient developed multiple organ failure leading to death within only seven days of the beginning of the symptomatology. [ABSTRACT FROM AUTHOR]

Copyright of Iatreia is the property of Universidad de Antioquia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The immunosuppression due to autoimmune conditions like Systemic Lupus Erythematosus (SLE) or the treatment with immune-modulators, predisposes the patient to have infections in a bigger proportion compared with the general population. In these patients the opportunistic infections are the main cause of death. Aspergillus fumigatus is the most frequent agent in the invasive aspergillosis, which has a low frequency and a very high mortality. The multi-systemic compromise secondary to this infection usually corresponds to advanced stages of the disease with a mortality over 90% despite the adequate and early treatment. [ABSTRACT FROM AUTHOR]

Mucopolysaccharidosis type I or mucopolisacaridosis type I is a rare genetic disease, with a severe and fast multiorganic damage profile and fatal prognosis in the early years of age. It belongs to the lysosomal storage diseases (LSD) group pathologies. As an LSD, mucopolisacaridosis type I is due to the lack of the α-L-iduronidase enzyme. Enzyme replacement therapy (ERT) with laronidase is an effective treatment choice. It is available in Mexico since 2005. In the Hospital UMAE 25 of the Mexican Institute of Social Security (IMSS) in Monterrey, Nuevo Leon, Mexico, three patients have been treated and followed since 2006, with a close surveillance on their clinical evolution. The ERT with laronidase is expensive, relatively new and with little experience in Mexico, so there is a real need of knowing clinical evolution as well as overall treatment efficacy from baseline pre-treatment stage to date. Data on physical, functional and biochemical changes in these patients is presented. [ABSTRACT FROM AUTHOR]

Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. In the last two decades there has been an exponential increase in the transplant of multiple organs, together with an increment in terms of the total number of successful organ grafts, and the quantity of centers that carry out organ transplantations.. Transplant success offers a viable alternative for patients who would have succumbed to multiple organ dysfunction in the past. Material and methods. Descriptive transversal study; 323 participants above 18-years of age, inhabitants of Durango's city metropolitan area took part in the study. A Personal Information registry form and a questionnaire comprised of 21 questions on organ donation and transplant knowledge were used. Results. Of the total 323 participants in the study 85% refer never to have been present or have taken part in talks on topics related to organ donation and transplant. Furthermore, it was observed that 64% of the studied population demonstrates to have general knowledge of concepts related to brain death. Conclusions. There is ignorance related to which they are the local institutions where organ procurement and transplants are performed. There is lack of knowledge on these topics mainly due to the lack of emphasis given to the promotion of informative talks organized by health institutions, mass media, educational institutions and labor centers. [ABSTRACT FROM AUTHOR]

The hemophagocytic syndrome is defined as a disorder of the mononuclear phagocytic system, characterized by a lymphohistiocytic infiltration with cells of normal morphology with multiple organ involved that presents a phenomenon of hemophagocytosis in the histopatology as a primary feature. We report the case of a child who began acutely with fever, maculopapular rash, petechiae, splenomegaly and pancytopenia; the diagnosis of hemophagocytic syndrome was conirmed with the presenting data of hemophagocytosis in the bone marrow aspirate. The patient received an early diagnosis, a key situation for her prognosis. [ABSTRACT FROM AUTHOR]