Within existing traceability systems for patient safety, the management of high risk drugs is a critical aspect. Among these, antineoplastic drugs are especially relevant. The traceability of these drugs in this project involves all processes of the oncological pharmacotherapeutic chain: e-prescription, pharmaceutical validation, preparation, dispensing and administration with bar code verification, and mutidisciplinary patient follow-up. After the implantation of new technologies, it is essential to perform both a technical evaluation of these such as the perceptions of their users, in this case nursing professionals and patients. Therefore, an observational study was performed one year after its implantation on the administration of cytostatics with bar code, in which 30% of observations with incidence were detected; of these, 42.5% were related to the operating procedure and 57.5% related to faults in the technology. The result of a safety perception study performed on patients one year after its implantation led to obtaining 95% feeling "total safety" and 4% "significant safety", with 1% remaining "indifferent"; when the study was repeated three years later, the percentages were 66.6% "total safety", 33.3% "significant safety" and any "indifferent". As for the study performed in 2010 to ascertain the opinion of nursing staff in regard to the safety of this administration system, 70% stated they "strongly agreed" and 30% "agreed"; 20% stated they had avoided a medication error thanks to the bar code. According to the results obtained in 2014, 69% "strongly agreed", 31% "agreed", and 31% had avoided an error. All this has led to the detection of possible faults, in addition to new actions to improve the system. These are always consensual and involve all participants. [ABSTRACT FROM AUTHOR]