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Introduction: Systemic arterial hypertension represents a health problem worldwide, of these there is still a group that presents resistance to conventional pharmacological treatment, renal sympathetic denervation represents a treatment option for these patients. Continuous blood pressure monitoring is a non-invasive method to measure blood pressure and diagnose patients with resistant high blood pressure who require renal denervation. Objective: To evaluate the blood pressure response after renal denervation at a 12-month follow-up after the procedure using the continuous blood pressure monitoring. Methods: An observational, descriptive, ambispective, longitudinal study was carried out. Twenty-one patients of both genders with a diagnosis of resistant high blood pressure after being treated with renal denervation were studied. Results: A total of 21 patients were included. Of these, 52% are women and 48% are men. With an average age of 55.29 +12.88 years. A pretreatment mean value of systolic pressure (MAPA) was obtained, of 147.43 +16.07 and post-treatment of 136.19 + 13.98. The values were statistically significant (p=0.02), with a decrease in mean systolic pressure of 11.24 +17.8, however the mean diastolic pressure MAPA did not present significant differences. Conclusions: resistant high blood pressure is multifactorial and one of the treatment options is renal denervation. However, the sample in this study is very small, and several variables may have influenced the outcome, such as close monitoring of treatment with periodic consultations, among others. [ABSTRACT FROM AUTHOR]