1. Dectin 1a orquesta respuestas complejas en linajes inmunocompetentes: hacia β-Glucanos de origen fúngico.
- Author
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Rodríguez Tapia, Julián David, De Moya Hernández, Yurina, García Cuan, Aracely, Palma Camargo, María Fernanda, and Torres Cantillo, Freddy José
- Abstract
In fungi, β-Glucans (bG), composed of glucose, perform various functions, such as compo-nents of extracellular matrices and energy reserves. The interest in its study is due to its im-munomodulatory and antitumor properties. The present review comprehensively presents the molecular interactions behind these effects that are still limitedly understood, so there is a knowledge gap related to their mechanisms and effects in humans. A relevant aspect found through the nonsystematic exploration of the literature is the ligand-receptor dynamics be-tween: β-Glucans (bG) and molecular pattern receptors (PRRs) key in their recognition, such as Dectin1 and the membrane-type complement receptor. 3 (CR3), separately and together. Thus, bG, Dectin1 and CR3 were shown to orchestrate a cellular immune response. It is es-sential to recognize the need for: a specific molecular weight monitoring standard and further research on β-glucan receptors, such as CR3. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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