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The mechanisms that favor reproductive isolation are a topic of study in the evolutionary process of plants. Subjecting domestic plants to artificial selection could be considered as a biological model in sympatric speciation. The morphology of the flower and the phenological stage of blooming of Hyptis suaveolens: wild, weed and domesticated forms were studied. Significant differences were observed in the floral structure (P<0.05): in the size of the flower tube (highest in the domesticated form), length of style (highest in the wild form), filament's stamens and anthers (highest in the wild form). There was also a significant difference in respect to length of the blooming period (P<0.001): 20.2 and 24 days in the domestic and wild forms, respectively. The weed population showed intermediate values suggesting wild-domestic hybridizing and genetic infiltration. It was inferred (suggested) that artificial selection produces changes that allows autogamy in the domestic variety of H. suaveolens, thus favoring the process towards reproductive isolation. [ABSTRACT FROM AUTHOR]